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The Effects of Panax Ginseng Radix Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on the Heart Rate Variability (인삼약침과 산조인약침이 정상인의 심박 변이도에 미치는 영향)

  • Seol, Hyun;Song, Beom-Yong;Yook, Tae-Han
    • Journal of Acupuncture Research
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    • v.26 no.5
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    • pp.19-28
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    • 2009
  • Objectives : We tried to investigate the effects of Panax Ginseng Radix pharmacopuncture and Zizyphi Spinosi Semen pharmacopuncture on human body with the Heart Rate Variability (HRV) in adult man. As well as we tried to investigate how safe Panax Ginseng Radix and Zizyphi Spinosi Semen pharmacopuncture on the the human being. Methods : We investigated on 44 healthy volunteers consisted of 16 subjects in Panax Ginseng Radix pharmacopuncture group, 13 subjects in Zizyphi Spinosi Semen pharmacopuncture group and 15 subjects in Normal Saline. We ruled out subjects who wasn't stable by rest, with in the limit of normal heart beat(60-120cycle/min). Study form was a randomized, clinical trial. Each group was injected Panax Ginseng Radix pharmacopuncture, Zizyphi Spinosi Semen pharmacopuncture and Normal Saline $0.2m{\ell}$ at $GB_{21}$(Kyonjong). We measured HRV on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 13.0 for windows was used to analyze the data by the paired t-test(in the group) and Anova test(among the groups) were used to verify the result. Results : 1. After Panax Ginseng Radix pharmacopuncture injection, SDNN was significantly high, pNN50 was significantly low, Ln(TP) was significantly high, Ln(VLF) was significantly high, Ln(LF) was significantly high at 30 minutes. 2. After Zizyphi Spinosi Semen pharmacopuncture injection, Complexity was significantly low, Ln(VLF) was significantly high at 30 minutes. 3. HRV-index made a significant difference between the Zizyphi Spinosi Semen pharmacopuncture and normal saline at 5 minutes(p=0.02). 4. There wasn's any pain the injected region and whole body, rubefaction, uredo, nausea, vomiting, colic, headache, dizziness within 24 hours. Measured data and mean value of Mean-HRV was within normal range. Conclusions : The results suggested that and Panax Ginseng Radix pharmacopuncture in healthy adult man tended to activate the vagus nervous system within normal range.

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Comparison research of HRV between Postpartum Women and Normal Women (산후 여성의 심박변이도 특성 연구)

  • Kang, Mun-Su;Park, Hyun-Chul;Kim, Lak-Hyung
    • Journal of Oriental Neuropsychiatry
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    • v.17 no.2
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    • pp.179-185
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    • 2006
  • Objective : This research was designed to study the characteristics of heart rate variability in postpartum women compared with normal women. Method : HRV data of postpartum women were gathered from 255 women who was hospitalized for oriental postpartum treatments(Age : 25-35). HRV data of comparison group were gathered from 327 women who visited hospital to check up their health(Age : 25-35). The SPSS 12.0 for windows was used to analyze the date and the independent samples t-test was used to verify the result. Result : 1. Mean-RR and SDNN of postpartum women group significantly decreased compared with that of normal women group. But, Heart Rate of postpartum women group significantly increased compared with that of normal women group. 2. HRV-Index, RMSSD and SDSD of postpartum women group significantly decreased compared with that of normal women group. pNN50 of postpartum women group significantly increased compared with that of normal women group. 3. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of postpartum women group significantly increased compared with that of normal women group. 4. There were no significant differences in Normal LF, Normal HF and LF/DF Ratio between postpartum women group and normal women group. Conclusion : The result suggest that the function of heart of postpartum women group significantly decreased compared with that of normal women group. Futhermore although the ANS maintained the balance in the range of normality, the sympathetic nervous system frequently revitalized which caused increasing the heart of pulsation.

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Nonlinear Compression Characteristics of Highly Plastic Clays and Silts of Korea South Coast (한국 남부 해안 고소성 점토 및 실트의 비선형 압축특성 연구)

  • Hong, Seok-Woo;Im, Jong-Chul
    • Journal of Navigation and Port Research
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    • v.36 no.3
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    • pp.181-187
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    • 2012
  • Highly plastic clays in their normally consolidated states are not always linear but are concave downwards. Thus their compression index deceases with the increase of consolidation pressure. The $e-{\log}{\sigma}_{\upsilon}{\prime}$ curves of plastic or non-plastic silty clays are not linear but are convex upwards. In this paper, consolidation tests were conducted with several undisturbed field soils of Korea south coast and their $e-{\log}{\sigma}_{\upsilon}{\prime}$ plots are not always linear. In case of using Butterfield's method(liquid limit 50~100%), ${\ln}{\upsilon}-{\ln}{\sigma}_{\upsilon}{\prime}$ plots are linear. But some undisturbed samples which have void ratio over 2.24, liquid limit over 100% and plasticity index over 60% are not linear. In results of consolidation tests with remolded samples which contain silt(fly ash) contents of 90% has compression index increasing with the increase in consolidation pressure.

An Empirical Study on the Effect of Transparency and CSR On Financial Performance and Firm Value (회계투명성과 CSR이 재무적 성과와 기업가치에 미치는 영향)

  • Oh, Sang-Hui
    • Management & Information Systems Review
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    • v.31 no.3
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    • pp.117-139
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    • 2012
  • The purpose of this study is to examine of transparency and Corporate Social Responsibility(CSR) on financial performance and firm value. The empirical results are as follows: First, we finds that ROA showed significant effect of all transparency measures exception QAS measure and Tobin's Q showed significant effect of CITSA, SCTSA, SETR and SATSA. Second, 'Total-ROA' and 'ROA' models showed significant positive effects of lnCSR(TranD${\times}$lnCSR) and ROA, also 'Total-Tobin's Q' and 'Tobin's Q' model had same results. Consequently, this study results had that The firms with higher transparency and higher CSR exhibit better financial performance and firm value.

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Columnar variant of papillary carcinoma in the thyroglossal duct cyst with progression to lung metastasis

  • Yun, Yujung;Park, Hye Jung;Lee, Young Ki;Cho, Yongin;Kang, Beoduel;Kim, Hyun Ju;Lee, Jung-Hee;Jin, Moo-Nyun;Shin, Dong Yeob
    • Journal of Yeungnam Medical Science
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    • v.31 no.2
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    • pp.103-108
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    • 2014
  • Thyroglossal duct cyst (TGDC) carcinoma generally shows a favorable prognosis. If metastasis is present latently, it may not threaten the patient's life immediately. It has been shown, however, that larger than 1 cm papillary carcinoma (PC), level VI metastasis to the lymph node (LN), which is the nearest to the thyroid, independently predicts a worse prognosis. In the case presented herein, a 61-year-old female patient was diagnosed with an about 3 cm PC in the TGDC, particularly the columnar variant subtype, one of the aggressive variants. She had occult papillary thyroid microcarcinoma, but no LN metastasis. Even though she underwent the Sistrunk procedure and total thyroidectomy with central compartment neck dissection followed by high-dose radioactive iodine remnant ablation, however, the cancer cells spread to level IV neck LN, and finally to the lung. Therefore, when a patient is diagnosed with an aggressive histologic variant of PC in the TGDC, even without LN metastasis, the invasive surgical approach and close postoperative surveillance are necessary, with consideration of the risk of disease progression. Therefore, if it is possible to stratify the risk for patients, higher-risk patients can be offered a more invasive therapeutic approach.

Different Levels of N Supply Impacts on Seed Yield by Modulating C and N Metabolism in Brassica Napus

  • Lee, Bok-Rye;Lee, Hyo;Kim, Tae-Hwan
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.39 no.2
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    • pp.75-80
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    • 2019
  • Oilseed rape is known to crop having low nitrogen use efficiency (NUE) but requires high levels of N fertilizer. NUE is associated with N remobilization from source to sink organ, consequently affects seed yield. Remobilization of leaf N is also related to transport of C/N metabolites in phloem. However, interaction between seed yield and phloem transport was not fully documented. In response to seed yield, N and C metabolites and their transport into seed from bolting to pod filling stage investigated in two contrasting genotypes (Capitol and Pollen) cultivated under ample (HN) or limiting nitrate (LN) supply. Seed yield was significantly reduced in N limitation and its reduction rate was much lower in Capitol than in Pollen compared to HN treated plants. Amino acid and protein content was higher in Capitol than in Pollen at bolting stage. They gradually decreased during plant development but not significant between two cultivars and/or two treatments. Glucose, fructose and sucrose content were 1.8-,1.6- or 1.25-fold higher in LN condition than in HN condition, respectively. Amino acid and sucrose content in phloem were largely higher in Capitol than in Pollen under LN condition. These results indicate that the higher seed yield might be related to greater transport ability of amino acid and sucrose in phloem under LN condition.

Synthesis and evaluation of 64Cu-labeled avidin for lymph node imaging

  • Kang, Choong Mo;Kim, Hyunjung;Lee, Yong Jin;Choe, Yearn Seong
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.5 no.1
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    • pp.54-60
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    • 2019
  • Sentinel lymph node (SLN) imaging plays an important role in surgery of patients with breast cancer and melanoma. In this study, avidin (Av), a tetrameric protein glycosylated with mannose and N-acetylglucosamine molecules, was labeled with $^{64}Cu$ and then evaluated for LN imaging. $^{64}Cu$-Labeled $NeutrAvidin^{TM}$ (NAv), a non-glycosylated form of Av, was used for comparison. 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-conjugated Av and NAv were prepared from the corresponding proteins and DOTA-NHS ester, which were then labeled with copper-64 and purified using PD-10 columns. The numbers of DOTA molecules conjugated to Av and NAv were 4.9 and 3.3, respectively. [$^{64}Cu$]Cu-DOTA-conjugated Av and NAv were prepared in 93% and 73% radiochemical yields, respectively. In vitro serum stability study showed that copper-64 remained stable on all radiotracers for 24 h (>97%). MicroPET/CT images showed that high radioactivity was accumulated in LNs within 15 min after footpad-injection of radiotracers. Tissue distribution data of mice demonstrated significantly higher uptake in the popliteal (PO) LN than lumbar (LU) LN for $^{64}Cu$-labeled Av (relative % ID/g excluding the injection sites: 66.2% and 26.0%, respectively) compared with those of $^{64}Cu$-labeled NAv (43.0% and 49.2%, respectively). The results of this study suggest that mannose molecules on Av enabled the radiotracer to retain in the first LN after mouse footpad-injection.

Characteristics of Fermented Brown-Rice Suspension Prepared from Leuconostoc mesenteroides KC51 Strain (가수분해도가 상이한 현미 가수분해물에서 Leuconostoc mesenteroides KC51 균주 발효물의 특성)

  • In, Man-Jin;Oh, Nam-Soon;Kim, Dong-Chung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.38 no.8
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    • pp.1118-1123
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    • 2009
  • Brown-rice hydrolyzates with different degrees of hydrolysis (DH) were fermented using Leuconostoc mesenteroides (Ln. mesenteroides) KC51 strain at $30^{\circ}C$ for 15 hr. Changes in pH, titratable acidity, viable cell counts and phytate degradation during fermentation were investigated. The acid production was increased with increasing DH of brown-rice hydrolyzate. At high DH (48.2%), the pH and titratable acidity reached to pH 3.41 and 0.82% after 15 hr fermentation, respectively. Regardless of DH of brown-rice, however, the viable cell population of Ln. mesenteroides KC51 was slightly increased to $4.0\sim7.2{\times}10^8$ CFU/g during the 6 hr of cultivation. The phytate content in brown-rice hydrolyzates decreased with increasing DH of brown-rice hydrolyzates. The level of phytate was reduced to around 50% of initial concentration at high DH condition. When the fermented brown-rice was kept at $4^{\circ}C$, pH, titratable acidity and number of viable cells were nearly maintained for 14 days.

AN OPTIMAL INEQUALITY FOR WARPED PRODUCT LIGHTLIKE SUBMANIFOLDS

  • Kumar, Sangeet;Pruthi, Megha
    • Honam Mathematical Journal
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    • v.43 no.2
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    • pp.289-304
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    • 2021
  • In this paper, we establish several geometric characterizations focusing on the relationship between the squared norm of the second fundamental form and the warping function of SCR-lightlike warped product submanifolds in an indefinite Kaehler manifold. In particular, we find an estimate for the squared norm of the second fundamental form h in terms of the Hessian of the warping function λ for SCR-lightlike warped product submanifolds of an indefinite complex space form. Consequently, we derive an optimal inequality, namely $${\parallel}h{\parallel}^2{\geq}2q\{{\Delta}(ln{\lambda})+{\parallel}{\nabla}(ln{\lambda}){\parallel}^2+\frac{c}{2}p\}$$, for SCR-lightlike warped product submanifolds in an indefinite complex space form. We also provide one non-trivial example for this class of warped products in an indefinite Kaehler manifold.