• Journal of the Korean Chemical Society
• /
• v.30 no.2
• /
• pp.188-194
• /
• 1986

The rate constants for the solvolysis reactions of p-chlorobenzyl chloride in ethanol-water mixtures were determinded at 30${\circ}\;and\;40{\circ}$C up to 1,600bar. Rates of reaction were increased with increasing temperature and pressure, and decreased with increasing solvent composition of ethanol mole fraction. The plots of ln k against pressure are fitted to a second-order function in P, and values of ${\Delta}V^{\neq}\;and\;${\Delta}{\beta}^{\neq}$ are obtained. The values of ${\Delta}V^{\neq}\;and\;${\Delta}{\beta}^{\neq}$ extremum behavior at about 0.20 mole fraction of ethanol. This behavior is discussed in terms of solvent structure variation. From the relation between the plots of ln k versus the solvent parameter, q ≡ (D-1)/(2D+1), or the logarithmic molar water concentration, In $C_w$, it could be estimated that the reaction proceeds through $S_N1(2)$ mechanism.

• Journal of Gastric Cancer
• /
• v.18 no.1
• /
• pp.20-29
• /
• 2018

Purpose: Pre-operative lymph node (LN) size is a valuable parameter for determining treatment strategy for gastric cancer. However, a correlation between LN size and metastasis has not been established. Materials and Methods: Thirty-six LN-positive (LNP) and matched 36 LN-negative (LNN) patients were included, and pathology slides of the LNs of these patients were reviewed. All the LNs were measured along the long-axis (LA) and short-axis (SA), manually. Results: Average retrieved LNs were $37.3{\pm}19.8$ and $40.5{\pm}11.6$ in the LNN and LNP groups, respectively. In total 2,800 LNs, including 136 metastatic LNs (MLNs) and 2,664 non-metastatic LNs (nMLNs), were evaluated. Mean length was significantly more in MLNs along both, the LA and SA (MLN_LA vs. nMLN_LA: $4.97{\pm}3.84$ vs. $3.37{\pm}2.40mm$, MLN_SA vs. nMLN_SA: $3.86{\pm}3.19$ vs. $2.43{\pm}1.59mm$; P<0.001). However, 92.6% (126/136) and 95.6% (130/136) of MLNs were <10 mm along the LA and SA, respectively. In addition, only 22.2% of the LNP group exhibited an MLN as the largest LN. Conclusions: Pre-operative multi-detector computed tomography has limited ability in estimating the presence of metastasis in LNs because most MLNs are less than 10 mm, and only a small proportion of the LNP group exhibits an MLN as the largest MLN.

• Journal of Gastric Cancer
• /
• v.6 no.3
• /
• pp.154-160
• /
• 2006

Purpose: According to the 2nd English Edition of the Japanese Gastric Cancer Association (JGCA) in 1998, in case of distal gastric cancer, the 14v (superior mesenteric vein) lymph node (LN) is included in the N2 group. However, in Korea, a modified radical gastrectomy is performed, and a 14v LN dissection is not done as a routine procedure. Thus, we investigated the rate of metastatic 14v LNs, evaluated the necessity of dissection of the 14v LN, and searched for indications of 14v LN dissection. Materials and Methods: From April 2004 to August 2005, we enrolled the patients who were diagnosed as having advanced gastric cancer in the distal third portion of the stomach. We peformed a distal gastrectomy with D2 lymph node dissection as defined in the 2nd English edition of the JGCA classification. We calculated the positive rate of metastatic LNs of each station and analyzed the relationship between the positive rates of No.6 LNs and 14v LNs. We also compared the positive 14v LN group with the negative 14v LN group. Results: The total number of patients was 50, the mean age was 56 (range $30{\sim}80$) years, and sex ratio (Male/Female) was 1.63 : 1. In 47 (94%) cases, distal a gastrectomy with gastroduodenostomy was done, and in the remaining 3 (6%) cases, a distal gastrectomy with gastrojejunostomy was done. The most frequently metastatic LNs were nos. 3 and 6 (54%). The metastatic rate of the f4v LN was 10%, which was similar to that of LN no. 9. In the comparison of the 14v positive group with the 14v negative group, there were significant differences in the numbers of metastatic LNs (mean 25.4 vs 4.91, P<0.001) and the numbers of metastatic no. 6 LNs, (mean 6.8 vs 1.42, P<0.001), and if no. 6 LNs were metastatic, the possibility of metastasis to the 14v LN was 19.2%. In the 14v positive group, all cases were more than stage 3 by the UICC 6th edition. Conclusion: In cases of advanced cancer with metastasis to the no. 6 IN, there was a good chance of metastasis to the 14v LN. Thus, in the operative field, if the tumor is advanced to more than stage 3 by the UICC classification and the no. 6 LN is metastatic, a 14v LN dissection is necessary. However, the usefulness of a 14v LN dissection should be evaluated prospectively through an analysis of tumor recurrence and long-term survival.

• Journal of Mechanical Science and Technology
• /
• v.15 no.11
• /
• pp.1463-1471
• /
• 2001

The Kachanov and Rabotnov (K-R) creep damage model was interpreted and applied to type 316LN and HT-9 stainless steels. Seven creep constants of the model, A, B, $textsc{k}$, m, λ, ${\gamma}$, and q were determine d for type 316LN stainless steel. In order to quantify a damage parameter, the cavity was interruptedly traced during creep for measuring cavity area to be reflected into the damage equation. For type 316LN stainless steel, λ= $\varepsilon$R/$\varepsilon$* and λf=$\varepsilon$/$\varepsilon$R were 3.1 and increased with creep strain. The creep curve with λ=3.1 depleted well the experimental data to the full lifetime and its damage curve showed a good agreement when r=24. However for the HT-9 stainless steel, the values of λ and λf were different as λ=6.2 and λf=8.5, and their K-R creep curves did not agree with the experimental data. This mismatch in the HT-9 steel was due to the ductile fracture by softening of materials rather than the brittle fracture by cavity growth. The differences of the values in the above steels were attributed to creep ductilities at the secondary and the tertiary creep stages.

• Progress in Superconductivity and Cryogenics
• /
• v.6 no.1
• /
• pp.48-52
• /
• 2004

Breakdown characteristics of insulator-liquid nitrogen ($LN_2$) composite insulation for resistor type High $T_c$/ superconducting fault current limiter (HTSFCL) under ac and impulse voltage in $LN_2$ has been studied using model electrode systems. Electrodes for model electrode systems were made of SUS 304 contacted fiberglass reinforced plastic (FRP) and Au coated sapphire. The breakdown characteristics of model electrode systems were investigated experimentally for FRP thickness ranging from 1 mm to 5 mm. surface distance ranging from 2.5 mm to 7 mm and electrode gap ranging from 1 to 5 mm. The experimental data suggested that the breakdown voltage of model electrode systems in $LN_2$ is highly dependent on the surface distance, electrode gap as well as on the FRP thickness. Also, we had observed discharge traces and puncture due to high-voltage 60-Hz AC stress.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.15 no.11
• /
• pp.985-990
• /
• 2002

The electrical breakdown characteristics of liquid nitrogen(LN$\sub$2/) were studied under simulated quenching conditions for application of HTS apparatus. The experimental results for various quenching condition revealed that the breakdown voltage of LN$\sub$2/ with bubble flow velocity and gap spacing. In the case, breakdown voltage decreases gradually with the bubble velocity. When it is bubble velocity from 0 to 1 $\ell$ /min, breakdown voltage rapidly decreases but decreases from 2 $\ell$/min to 10 $\ell$/min slowly. The breakdown voltage for vertical electrode arrangement is higher than that for horizontal electrode arrangement. Also, it did a electric field and potential distribution interpreting at the liquid nitrogen when the bubble existed. The plots of equipotential lines for three cases are also shown.

• Bulletin of the Korean Space Science Society
• /
• 2004.10b
• /
• pp.281-284
• /
• 2004

According to the National Space Program of Korea, KARI (Korea Aerospace Research Institute) has been developing a large space simulator (working dimension; $\Phi8m\;\times\;L10m$) to verify the performance of future large satellites under the space environment conditions. Especially, a very low temperature condition of space will be simulated by shrouds covering the inside surface of the vessel. The surface of shrouds will be cooled down to 17K by liquid nitrogen (LN2) from ambient temperature and hence, an optimal LN2 circulation system design is necessary to remove gaseous nitrogen (GN2) sufficiently and maintain the shrouds at the LN2 temperature.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2002.08a
• /
• pp.58-63
• /
• 2002

For the experiment the four types of spacer were distinguished by arrangement. The flashover characteristic on each types of spacer was investigated and the flashover phenomena were observed to understand breakdown mechanism in liquid nitrogen($LN_{2}$). The spacer should be placed interior coil as an insulator, a cooling channel and s supporter of structures. The simulated electrode used in the experiment was made from five turns of HTS tape. Experimental results revealed that multi-layer and barrier effects did work well in Air but did not in $LN_{2}$. These result suggested that the flashover in LN2 caused by the bubbles due to partial discharge at micro gap, g. The flashover characteristics decreased to 70% when g is 0.2 mm. The degradation was improved by even treatment on surface of coil electrode.

• Journal of Korean Society of Environmental Engineers
• /
• v.33 no.3
• /
• pp.149-156
• /
• 2011

This experimental design and response surface methodology (RSM) have been applied to the investigation of the electro-UV-ultrasonic complex process for the disinfection of E. coli in the water. The disinfection reactions of electro-UV-ultrasonic process were mathematically described as a function of parameters power of electrolysis ($X_1$), UV ($X_2$), and ultrasonic process ($X_3$) being modeled by use of the Box-Behnken technique, which was used for fitting 2nd order response surface model. The application of RSM yielded the following regression equation, which is empirical relationship between the residual E. coli number (Ln CFU) in water and test variables in coded unit: residual E. coli number (Ln CFU) = 23.69 - 3.75 Electrolysis - 0.67 UV - 0.26 Ultrasonic - 0.16 Electrolysis UV + 0.05 Electrolysis Ultrasonic + 0.27 $Electrolysis^2$ + 0.14 $UV^2$ - 0.01 $Ultrasonic^2$). The model predictions agreed well with the experimentally observed result ($R^2$ = 0.983). Graphical 2D contour and 3D response surface plots were used to locate the optimum range. The estimated ridge of maximum response and optimal conditions for residual E. coli number (Ln CFU) using 'numerical optimization' of Design-Expert software were 1.47 Ln CFU/L and 6.94 W of electrolysis, 6.72 W of UV and 14.23 W of ultrasonic process. This study clearly showed that response surface methodology was one of the suitable methods to optimize the operating conditions and minimize the residual E. coli number of the complex disinfection.

• Journal of Acupuncture Research
• /
• v.29 no.4
• /
• pp.43-53
• /
• 2012

Objectives : This study was accomplished to investigate the effects of moxibustion at Jeonjung($CV_{17}$) on the heart rate variability(HRV) in healthy adults. And based on that, we tried to find out how moxibustion at Jeonjung($CV_{17}$) effects on the activity and balance of the autonomic nervous system Methods : We investigated on 50 healthy volunteers consisted of 24 subjects in moxibustion group and 24 subjects in control group. On the other hand, two volunteers were ruled out by standard of elimination. The study was established by randomized trial. Moxibustion was applied at Jeonjung($CV_{17}$) and rested during 10 minutes in moxibustion group. No treatment was executed in control group. We measured HRV 3 times : baseline measurement and after treatment in moxibustion group(after rest in control group) twice. The SPSS 12.0 for windows was used to analyze the data by paired t-test, Wilcoxon signed ranks test(in group) and Independent t-test, Mann-Whitney U-test (between the groups). Results : 1. In moxibustion group, mean HRT decreased significantly. Ln(VLF) increased significantly. Ln(TP) decreased significantly at $2^{nd}$ time and increased significantly at $3^{rd}$ time. SDNN, RMSSD, PSI, Ln(LF), Ln(HF), Normalized LF, Normalized HF and LF/HF ratio were not affected. 2. In control group, PSI and normalized HF decreased significantly. SDNN, Ln(TP), Ln(VLF), normalized LF and LF/HF ratio increased significantly. Mean HRT, RMSSD, Ln(LF) and Ln(HF) were not affected. Conclusions : This study suggest that moxibustion at Jeonjung($CV_{17}$) makes no effects on the balance of the autonomic nervous system.