• 제목/요약/키워드: $K^{+}$ channels

검색결과 4,177건 처리시간 0.03초

정보기술 산업에서의 인수 유형별 인수 의도 분석 (Intents of Acquisitions in Information Technology Industrie)

  • 조우제;장영봉;권영옥
    • 지능정보연구
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    • 제22권4호
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    • pp.123-138
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    • 2016
  • 전 세계적으로 기업의 중요한 전략적 수단으로 인수합병이 활발히 이루어지고 있고, 지능형 서비스 산업을 포함한 정보기술 산업에서의 인수합병 활동은 꾸준히 활발하게 진행되고 있다. 본 논문에서는 정보기술 산업 내에서 일어나는 인수합병 건에 대해 인수 기업 입장에서의 인수 의도에 초점을 두고 분석하였다. 특히, 두 하드웨어 기업 간, 하드웨어 기업 소프트웨어 기업 간, 두 소프트웨어 기업 간 인수합병 유형에 따라 인수 의도가 어떻게 다른지 비교하고자 하였고, 이를 위해 미국 정보기술 산업 내에서 1995년과 2010년 사이에 일어났던 1003개의 인수합병 건의 자료를 분석하였다. 인수 의도를 파악하는데 있어, 인수 기업의 입장에서 생산비용 절감 의도, 제품 개발 및 개선 의도, 고객층 확장 의도, 고객채널 확장 의도의 네 가지로 구분하여 측정하였다. 분석 결과 생산비용 절감 의도와 고객층 확장 의도는 하드웨어 기업이 피인수 기업일 때 더 많이 나타났고, 제품개발 의도는 하드웨어 기업이 인수 기업일 때 더 많이 나타났다. 그리고, 고객채널 확장 의도는 소프트웨어 기업이 피인수 기업일 때 더 많이 나타났다. 또한, 생산비용 절감 의도, 제품 개발 및 개선 의도를 제품생산 관련활동 의도로, 고객층 확장 의도와 고객채널 확장을 고객관련 활동 의도로 구분하여 비교하였을 때에는, 하드웨어 기업 간 인수합병에 비해, 두 소프트웨어 기업 간 인수합병에서 상대적으로 고객관련 활동 의도가 높은 비중을 나타내고 있음을 알 수 있었다. 활발하게 인수합병이 이루어지고 있는 세계적 추세와는 달리 국내 인수합병거래 규모는 선진국에 비해 매우 적은 수준이다. 본 연구는 인수합병이 보다 활발하게 이루어지고 있는 미국기술정보 산업에서의 인수 의도를 분석하여, 국내에서 인수합병 활동을 활성화하는 방안을 분석 및 개발하는데 기여하고자 한다.

Enhanced antidiabetic efficacy and safety of compound K/β-cyclodextrin inclusion complex in zebrafish

  • Nam, Youn Hee;Le, Hoa Thi;Rodriguez, Isabel;Kim, Eun Young;Kim, Keonwoo;Jeong, Seo Yule;Woo, Sang Ho;Lee, Yeong Ro;Castaneda, Rodrigo;Hong, Jineui;Ji, Min Gun;Kim, Ung-Jin;Hong, Bin Na;Kim, Tae Woo;Kang, Tong Ho
    • Journal of Ginseng Research
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    • 제41권1호
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    • pp.103-112
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    • 2017
  • Background: 20(S)-Protopanaxadiol 20-O-D-glucopyranoside, also called compound K (CK), exerts antidiabetic effects that are mediated by insulin secretion through adenosine triphosphate (ATP)-sensitive potassium ($K_{ATP}$) channels in pancreatic ${\beta}$-cells. However, the antidiabetic effects of CK may be limited because of its low bioavailability. Methods: In this study, we aimed to enhance the antidiabetic activity and lower the toxicity of CK by including it with ${\beta}$-cyclodextrin (CD) (CD-CK), and to determine whether the CD-CK compound enhanced pancreatic islet recovery, compared to CK alone, in an alloxan-induced diabetic zebrafish model. Furthermore, we confirmed the toxicity of CD-CK relative to CK alone by morphological changes, mitochondrial damage, and TdT-UTP nick end labeling (TUNEL) assays, and determined the ratio between the toxic and therapeutic dose for both compounds to verify the relative safety of CK and CD-CK. Results: The CD-CK conjugate ($EC_{50}=2.158{\mu}M$) enhanced the recovery of pancreatic islets, compared to CK alone ($EC_{50}=7.221{\mu}M$), as assessed in alloxan-induced diabetic zebrafish larvae. In addition, CD-CK ($LC_{50} =20.68{\mu}M$) was less toxic than CK alone ($LC_{50}=14.24{\mu}M$). The therapeutic index of CK and CD-CK was 1.98 and 9.58, respectively. Conclusion: The CD-CK inclusion complex enhanced the recovery of damaged pancreatic islets in diabetic zebrafish. The CD-CK inclusion complex has potential as an effective antidiabetic efficacy with lower toxicity.

모듈형 환자감시기와 중앙 환자감시기로 구성되는 환자감시시스템 시제품의 개발: 전체구조 및 사양 (Development of a Prototype Patient Monitoring System with Module-Based Bedside Units and Central Stations: Overall Architecture and Specifications)

  • 우응제;박승훈;전병문;문창욱;이희철;김승태;김형진;서재준;채경명;박종찬;최근호;이왕진;김경수
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1996년도 춘계학술대회
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    • pp.315-319
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    • 1996
  • We have developed a prototype patient monitoring system including module-based bedside units, interbed network, and central stations. A bedside unit consists of a color monitor and a main CPU unit with peripherals including a module controller. It can also include up to 3 module cases and 21 different modules. In addition to the 3-channel recorder module, six different physiological parameters of ECG, respiration, invasive blood pressure, noninvasive blood pressure, body temperature, and arterial pulse oximetry with plethysmogaph are provided as parameter modules. Modules and a module controller communicate with up to 1Mbps data rate through an intrabed network based on RS-485 and HDLC protocol. Bedside units can display up to 12 channels of waveforms with any related numeric informations simultaneously. At the same time, it communicates with other bedside units and central stations through interbed network based on 10Mbps Ethernet and TCP/IP protocol. Software far bedside units and central stations fully utilizes gaphical user interface techniques and all functions are controlled by a rotate/push button on bedside unit and a mouse on central station. The entire system satisfies the requirements of AAMI and ANSI standards in terms of electrical safety and performances. In order to accommodate more advanced data management capabilities such as 24-hour full disclosure, we are developing a relational database server dedicated to the patient monitoring system. We are also developing a clinical workstation with which physicians can review and examine the data from patients through various kinds of computer networks far diagnosis and report generation. Portable bedside units with LCD display and wired or wireless data communication capability will be developed in the near future. New parameter modules including cardiac output, capnograph, and other gas analysis functions will be added.

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차세대 지상파 4K UHD & HD 융합방송을 위한 전송 시스템 개발에 관한 연구 (A Study of Development of Transmission Systems for Next-generation Terrestrial 4K UHD & HD Convergence Broadcasting)

  • 오종규;원용주;이진섭;김용환;백종호;김준태
    • 방송공학회논문지
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    • 제19권6호
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    • pp.767-788
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    • 2014
  • 세계적으로 아날로그 방송에서 디지털 방송으로의 전환이 마무리되고 있는 가운데, 앞으로 다가올 UHDTV 등 실감의 대용량 방송 및 방송 통신 융합 환경에 대비하기 위한 새로운 차기 방송 표준에 관한 연구의 필요성이 날로 높아져 가고 있다. 특히, 저해상도 서비스에 머물러 있던 모바일 방송에서는 기존 HD급의 서비스 제공이 가능한 모바일 실감방송으로 진화하기 때문에 고정/이동 방송 서비스가 동시에 가능한 고효율 전송 원천 기술 개발이 이루어질 필요가 있다. 이에 최근 지상파 단일 채널을 통해 4K UHD (거치형) & HD (모바일) 방송 서비스를 동시에 제공하는 융합방송 시스템 개발에 대해서 연구가 진행되고 있다. 본 논문에서는 최신의 디지털 방송 전송 기법 및 영상 압축 기술에 대해서 소개하고, 지상파 단일 채널을 통해 4K & HD 융합방송 서비스를 제공하기 위한 서비스 모델 및 전송 요구 사항들에 대해서 분석한다. 이 후 최신의 방송 전송 기법 및 영상 압축 기술을 적용하였을 때, 6MHz & 8MHz 대역폭에서 지상파 4K UHD & HD 융합방송을 전송하기 위해 필요한 최적의 전송 파라메터를 도출하고 이를 이용해 AWGN 및 TU-6 채널에서의 융합방송 수신 성능을 검증하였다. 이를 통해 6MHz 대역폭에서의 원활한 HD 모바일 데이터의 수신이 140 Km/h 수신기 속도까지는 가능하나, 그 이상에서는 대역폭의 한계로 인해 원활한 수신이 이루어지지 않음을 확인하였다. 그리고 대역폭을 8 MHz로 확장할 경우, 매우 빠른 다중경로 페이딩 채널에서도 4K UHD 및 HD 계층 데이터의 수신이 원활히 이루어지는 것을 보였다.

도입주체에 따른 인터넷경로의 도입효과 (The Impact of the Internet Channel Introduction Depending on the Ownership of the Internet Channel)

  • 유원상
    • 마케팅과학연구
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    • 제19권1호
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    • pp.37-46
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    • 2009
  • The Census Bureau of the Department of Commerce announced in May 2008 that U.S. retail e-commerce sales for 2006 reached $ 107 billion, up from $ 87 billion in 2005 - an increase of 22 percent. From 2001 to 2006, retail e-sales increased at an average annual growth rate of 25.4 percent. The explosive growth of E-Commerce has caused profound changes in marketing channel relationships and structures in many industries. Despite the great potential implications for both academicians and practitioners, there still exists a great deal of uncertainty about the impact of the Internet channel introduction on distribution channel management. The purpose of this study is to investigate how the ownership of the new Internet channel affects the existing channel members and consumers. To explore the above research questions, this study conducts well-controlled mathematical experiments to isolate the impact of the Internet channel by comparing before and after the Internet channel entry. The model consists of a monopolist manufacturer selling its product through a channel system including one independent physical store before the entry of an Internet store. The addition of the Internet store to this channel system results in a mixed channel comprised of two different types of channels. The new Internet store can be launched by the independent physical store such as Bestbuy. In this case, the physical retailer coordinates the two types of stores to maximize the joint profits from the two stores. The Internet store also can be introduced by an independent Internet retailer such as Amazon. In this case, a retail level competition occurs between the two types of stores. Although the manufacturer sells only one product, consumers view each product-outlet pair as a unique offering. Thus, the introduction of the Internet channel provides two product offerings for consumers. The channel structures analyzed in this study are illustrated in Fig.1. It is assumed that the manufacturer plays as a Stackelberg leader maximizing its own profits with the foresight of the independent retailer's optimal responses as typically assumed in previous analytical channel studies. As a Stackelberg follower, the independent physical retailer or independent Internet retailer maximizes its own profits, conditional on the manufacturer's wholesale price. The price competition between two the independent retailers is assumed to be a Bertrand Nash game. For simplicity, the marginal cost is set at zero, as typically assumed in this type of study. In order to explore the research questions above, this study develops a game theoretic model that possesses the following three key characteristics. First, the model explicitly captures the fact that an Internet channel and a physical store exist in two independent dimensions (one in physical space and the other in cyber space). This enables this model to demonstrate that the effect of adding an Internet store is different from that of adding another physical store. Second, the model reflects the fact that consumers are heterogeneous in their preferences for using a physical store and for using an Internet channel. Third, the model captures the vertical strategic interactions between an upstream manufacturer and a downstream retailer, making it possible to analyze the channel structure issues discussed in this paper. Although numerous previous models capture this vertical dimension of marketing channels, none simultaneously incorporates the three characteristics reflected in this model. The analysis results are summarized in Table 1. When the new Internet channel is introduced by the existing physical retailer and the retailer coordinates both types of stores to maximize the joint profits from the both stores, retail prices increase due to a combination of the coordination of the retail prices and the wider market coverage. The quantity sold does not significantly increase despite the wider market coverage, because the excessively high retail prices alleviate the market coverage effect to a degree. Interestingly, the coordinated total retail profits are lower than the combined retail profits of two competing independent retailers. This implies that when a physical retailer opens an Internet channel, the retailers could be better off managing the two channels separately rather than coordinating them, unless they have the foresight of the manufacturer's pricing behavior. It is also found that the introduction of an Internet channel affects the power balance of the channel. The retail competition is strong when an independent Internet store joins a channel with an independent physical retailer. This implies that each retailer in this structure has weak channel power. Due to intense retail competition, the manufacturer uses its channel power to increase its wholesale price to extract more profits from the total channel profit. However, the retailers cannot increase retail prices accordingly because of the intense retail level competition, leading to lower channel power. In this case, consumer welfare increases due to the wider market coverage and lower retail prices caused by the retail competition. The model employed for this study is not designed to capture all the characteristics of the Internet channel. The theoretical model in this study can also be applied for any stores that are not geographically constrained such as TV home shopping or catalog sales via mail. The reasons the model in this study is names as "Internet" are as follows: first, the most representative example of the stores that are not geographically constrained is the Internet. Second, catalog sales usually determine the target markets using the pre-specified mailing lists. In this aspect, the model used in this study is closer to the Internet than catalog sales. However, it would be a desirable future research direction to mathematically and theoretically distinguish the core differences among the stores that are not geographically constrained. The model is simplified by a set of assumptions to obtain mathematical traceability. First, this study assumes the price is the only strategic tool for competition. In the real world, however, various marketing variables can be used for competition. Therefore, a more realistic model can be designed if a model incorporates other various marketing variables such as service levels or operation costs. Second, this study assumes the market with one monopoly manufacturer. Therefore, the results from this study should be carefully interpreted considering this limitation. Future research could extend this limitation by introducing manufacturer level competition. Finally, some of the results are drawn from the assumption that the monopoly manufacturer is the Stackelberg leader. Although this is a standard assumption among game theoretic studies of this kind, we could gain deeper understanding and generalize our findings beyond this assumption if the model is analyzed by different game rules.

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Effect of Doxorubicin on Catecholamine Release in the Isolated Perfused Rat Adrenal Gland

  • Lim, Dong-Yoon;Oh, Song-Hoon;Seoh, Yoo-Seung;Lee, Eun-Sook;Kim, Il-Hwan;Jo, Seong-Ho;Hong, Soon-Pyo
    • The Korean Journal of Physiology and Pharmacology
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    • 제6권4호
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    • pp.215-223
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    • 2002
  • The present study was undertaken to investigate the effect of doxorubicin (DX) on secretion of catecholamines (CA) evoked by ACh, high $K^+,$ DMPP and McN-A-343 from the isolated perfused rat adrenal gland and to establish the mechanism of its action. DX $(10^{-7}{\sim}10^{-6}\;M)$ perfused into an adrenal vein for 60 min produced relatively dose- and time-dependent inhibition of CA secretory responses evoked by ACh $(5.32{\times}10^{-3}\;M),$ DMPP $(10^{-4}\;M)$ and McN-A-343 $(10^{-4}\;M).$ However, lower dose of DX did not affect CA secretion by high $K^+\;(5.6{\times}10^{-2}\;M),$ but its higher doses depressed time-dependently CA secretion evoked by high $K^+.$ DX itself did also fail to affect basal CA output. In adrenal glands loaded with DX $(3{\times}10^{-7}\;M),$ CA secretory responses evoked by Bay-K-8644, an activator of L-type $Ca^{2+}$ channels and cyclopiazonic acid, an inhibitor of cytoplasmic $Ca^{2+}-ATPase$ were time-dependently inhibited. Furthermore, daunorubicin $(3{\times}10^{-7}\;M),$ given into the adrenal gland for 60 min, attenuated CA secretory responses evoked by ACh, high $K^+,$ DMPP and McN-A-343. Taken together, these results suggest that DX causes relatively dose- and time-dependent inhibition of CA secretory responses evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors from the isolated perfused rat adrenal gland. However, lower dose of DX did not affect CA secretion by high $K^+,$ and higher doses of DX reduced time-dependently CA secretion of high $K^+.$ It is thought that these effects of DX may be mediated by inhibiting both influx of extracellular calcium into the rat adrenomedullary chromaffin cells and intracelluar calcium release from the cytoplasmic store. Also, there was no difference in the mode of action between DX and daunorubicin in rat adrenomedullary CA secretion.

Quercetin Inhibits the 5-Hydroxytryptamine Type 3 Receptor-mediated Ion Current by Interacting with Pre-Transmembrane Domain I

  • Lee, Byung-Hwan;Jung, Sang-Min;Lee, Jun-Ho;Kim, Jong-Hoon;Yoon, In-Soo;Lee, Joon-Hee;Choi, Sun-Hye;Lee, Sang-Mok;Chang, Choon-Gon;Kim, Hyung-Chun;Han, YeSun;Paik, Hyun-Dong;Kim, Yangmee;Nah, Seung-Yeol
    • Molecules and Cells
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    • 제20권1호
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    • pp.69-73
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    • 2005
  • The flavonoid, quercetin, is a low molecular weight substance found in apple, tomato and other fruit. Besides its antioxidative effect, quercetin, like other flavonoids, has a wide range of neuropharmacological actions including analgesia, and motility, sleep, anticonvulsant, sedative and anxiolytic effects. In the present study, we investigated its effect on mouse 5-hydroxytryptamine type 3 ($5-HT_{3A}$) receptor channel activity, which is involved in pain transmission, analgesia, vomiting, and mood disorders. The $5-HT_{3A}$ receptor was expressed in Xenopus oocytes, and the current was measured with the two-electrode voltage clamp technique. In oocytes injected with $5-HT_{3A}$ receptor cRNA, quercetin inhibited the 5-HT-induced inward peak current ($I_{5-HT}$) with an $IC_{50}$ of $64.7{\pm}2.2{\mu}M$. Inhibition was competitive and voltage-independent. Point mutations of pre-transmembrane domain 1 (pre-TM1) such as R222T and R222A, but not R222D, R222E and R222K, abolished inhibition, indicating that quercetin interacts with the pre-TM1 of the $5-HT_{3A}$ receptor.

한의진단명과 진단요건의 표준화 연구II (표준화 실례) - 2차년도 연구결과 중간 보고- (Standardization and unification of the terms and conditions used for diagnosis in oriental medicine. II)

  • 양기상;최승훈;최선미;박경모;정우열;안규석;엄현섭;김성훈;전병훈;김정범;권영규;박중현;김동희;장혜옥;김성우;신상우;고현
    • 한국한의학연구원논문집
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    • 제2권1호
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    • pp.381-401
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    • 1996
  • The diagnostic requirements were suggested and explained regarding the systems of differentiation of syptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : -differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to reletive excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) -differentiation of diseases according to pathological changes of the viscera and their interrelation(臟腑辨證) -analysing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following odor : another name(異名), notion of diagnosis parrern(證候槪念), index of differentiation of syptoms and sings(辨證指標), the main point of diagnosis(診斷要點), analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a wayof curing a diseases(治法), prescription(處方) , herbs in common use(常用藥物), dieases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

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Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330 and R355-357) in the cytosolic C-terminal helix

  • Kim, Sung Eun;Kim, Myoung-Hwan;Woo, Joohan;Kim, Sung Joon
    • The Korean Journal of Physiology and Pharmacology
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    • 제24권6호
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    • pp.555-561
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    • 2020
  • TWIK-related two-pore domain K+ channel-2 (TREK-2) has voltage-independent activity and shows additional activation by acidic intracellular pH (pHi) via neutralizing the E332 in the cytoplasmic C terminal (Ct). We reported opposite regulations of TREK-2 by phosphatidylinositol 4,5-bisphosphate (PIP2) via the alkaline K330 and triple Arg residues (R355-357); inhibition and activation, respectively. The G334 between them appeared critical because its mutation (G334A) endowed hTREK-2 with tonic activity, similar to the mutation of the inhibitory K330 (K330A). To further elucidate the role of putative bent conformation at G334, we compared the dual mutation forms, K330A/G334A and G334A/R355-7A, showing higher and lower basal activity, respectively. The results suggested that the tonic activity of G334A owes to a dominant influence from R355-7. Since there are additional triple Arg residues (R377-9) distal to R355-7, we also examined the triple mutant (G334A/R355-7A/R377-9A) that showed tonic inhibition same with G334A/R355-7A. Despite the state of tonic inhibition, the activation by acidic pHi was preserved in both G334A/R355-7A and G334A/R355-7A/R377-9A, similar to the R355-7A. Also, the inhibitory effect of ATP could be commonly demonstrated under the activation by acidic pHi in R355-7A, G334A/R355-7A, and G334A/R355-7A/R377-9A. These results suggest that the putative bent conformation at G334 is important to set the tug-of-war between K330 and R355-7 in the PIP2-dependent regulation of TREK-2.

Landsat 8 위성 기반 고해상도 지표면 광대역 알베도 산출 (Landsat 8-based High Resolution Surface Broadband Albedo Retrieval)

  • 이다래;서민지;이경상;최성원;성노훈;김홍희;진동현;권채영;허모랑;한경수
    • 대한원격탐사학회지
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    • 제32권6호
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    • pp.741-746
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    • 2016
  • 알베도는 태양에너지의 흡수량을 결정하는 주요 기후 변수 중 하나로서, 이러한 알베도를 산출하는 것은 기후 변화 연구에 있어 중요한 과정이다. 이 때, 산출된 알베도 자료를 효율적으로 사용하기 위해서는 높은 공간해상도와 장기간의 일관성 있는 산출이 중요하게 고려된다. 따라서 본 연구에서는 Landsat 8을 기반으로 Landsat 7과의 일관성을 유지한 고해상도 지표면 광대역 알베도를 산출하였다. 먼저, Landsat 7과 Landsat 8의 채널 별 일관성을 분석한 결과, 상관계수(R)가 평균 0.96으로 높은 상관성을 보였다. 이러한 결과를 바탕으로 Landsat 7 알베도와 Landsat 8 반사도 채널 자료를 다중회귀분석에 적용하여 Landsat 8 광대역 알베도 전환 식을 도출하였다. 도출된 식을 통해 Landsat 8 지표면 광대역 알베도를 산출하고, Landsat 7 알베도 자료와 비교하여 검증하였다. 그 결과 R-square($R^2$)가 0.89, Root Mean Square Error (RMSE)가 0.003의 높은 정확도를 보였다.