Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330 and R355-357) in the cytosolic C-terminal helix |
Kim, Sung Eun
(Department of Physiology, Seoul National University College of Medicine)
Kim, Myoung-Hwan (Department of Physiology, Seoul National University College of Medicine) Woo, Joohan (Department of Physiology, Dongguk University College of Medicine) Kim, Sung Joon (Department of Physiology, Seoul National University College of Medicine) |
1 | Enyedi P, Czirjak G. Molecular background of leak K+ currents: two-pore domain potassium channels. Physiol Rev. 2010;90:559-605. DOI |
2 | Lotshaw DP. Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels. Cell Biochem Biophys. 2007;47:209-256. DOI |
3 | Mathie A, Veale EL. Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain. Pflugers Arch. 2015;467:931-943. DOI |
4 | Djillani A, Mazella J, Heurteaux C, Borsotto M. Role of TREK-1 in health and disease, focus on the central nervous system. Front Pharmacol . 2019;10:379. DOI |
5 | Lesage F, Terrenoire C, Romey G, Lazdunski M. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem. 2000;275:28398-28405. DOI |
6 | Niemeyer MI, Cid LP, Gonzalez W, Sepulveda FV. Gating, regulation, and structure in K2P K+ channels: in varietate concordia? Mol Pharmacol. 2016;90:309-317. DOI |
7 | Noel J, Sandoz G, Lesage F. Molecular regulations governing TREK and TRAAK channel functions. Channels (Austin). 2011;5:402-409. DOI |
8 | Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M, Honore E. A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO J. 2005;24:44-53. DOI |
9 | Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E. Upand down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch. 2007;455:97-103. DOI |
10 | Honore E, Maingret F, Lazdunski M, Patel AJ. An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1. EMBO J. 2002;21:2968-2976. DOI |
11 | Kim Y, Gnatenco C, Bang H, Kim D. Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi. Pflugers Arch. 2001;442:952-960. DOI |
12 | Soussia IB, Choveau FS, Blin S, Kim EJ, Feliciangeli S, Chatelain FC, Kang D, Bichet D, Lesage F. Antagonistic effect of a cytoplasmic domain on the basal activity of polymodal potassium channels. Front Mol Neurosci. 2018;11:301. DOI |
13 | Woo J, Shin DH, Kim HJ, Yoo HY, Zhang YH, Nam JH, Kim WK, Kim SJ. Inhibition of TREK-2 K(+) channels by PI(4,5)P2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase. Pflugers Arch. 2016;468:1389-1402. DOI |
14 | Woo J, Jun YK, Zhang YH, Nam JH, Shin DH, Kim SJ. Identification of critical amino acids in the proximal C-terminal of TREK-2 K+ channel for activation by acidic pHi and ATP-dependent inhibition. Pflugers Arch. 2018;470:327-337. DOI |
15 | Woo J, Jeon YK, Zhang YH, Nam JH, Shin DH, Kim SJ. Triple arginine residues in the proximal C-terminus of TREK K+ channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate. Am J Physiol Cell Physiol. 2019;316:C312-C324. DOI |
16 | Dong H, Sharma M, Zhou HX, Cross TA. Glycines: role in -helical membrane protein structures and a potential indicator of native conformation. Biochemistry. 2012;51:4779-4789. DOI |
17 | Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL, Ma XY. Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Sci Rep. 2016;6:21248. DOI |
18 | Jacob J, Duclohier H, Cafiso DS. The role of proline and glycine in determining the backbone flexibility of a channel-forming peptide. Biophys J. 1999;76:1367-1376. DOI |
19 | Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL Jr. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017;547:364-368. DOI |