• 제목/요약/키워드: $K^+$ currents

검색결과 2,804건 처리시간 0.031초

가정.사무용 기기의 고조파 전류 측정 (The Measurement of the Harmonic Currents in the Household & Office Appliances)

  • 서장철;강용철;김성수;남순열;박종근;명성호;강영식;최효열
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1996년도 추계학술대회 논문집 학회본부
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    • pp.149-151
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    • 1996
  • This paper reports the measurement results of the harmonic currents in the household and office appliances. The harmonic currents of 10 items are measured up to 20th order using the no distortion source. These results can be used as a raw data in determining the harmonic current limit in the household and office appliances.

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Presynaptic Mechanism Underlying Regulation of Transmitter Release by G Protein Coupled Receptors

  • Takahashi, Tomoyuki;Kajikawa, Yoshinao;Kimura, Masahiro;Saitoh, Naoto;Tsujimoto, Tetsuhiro
    • The Korean Journal of Physiology and Pharmacology
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    • 제8권2호
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    • pp.69-76
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    • 2004
  • A variety of G protein coupled receptors (GPCRs) are expressed in the presynaptic terminals of central and peripheral synapses and play regulatory roles in transmitter release. The patch-clamp whole-cell recording technique, applied to the calyx of Held presynaptic terminal in brainstem slices of rodents, has made it possible to directly examine intracellular mechanisms underlying the GPCR-mediated presynaptic inhibition. At the calyx of Held, bath-application of agonists for GPCRs such as $GABA_B$ receptors, group III metabotropic glutamate receptors (mGluRs), adenosine $A_1$ receptors, or adrenaline ${\alpha}2$ receptors, attenuate evoked transmitter release via inhibiting voltage-activated $Ca^{2+}$ currents without affecting voltage-activated $K^+$ currents or inwardly rectifying $K^+$ currents. Furthermore, inhibition of voltage-activated $Ca^{2+}$ currents fully explains the magnitude of GPCR-mediated presynaptic inhibition, indicating no essential involvement of exocytotic mechanisms in the downstream of $Ca^{2+}$ influx. Direct loadings of G protein ${\beta}{\gamma}$ subunit $(G{\beta}{\gamma})$ into the calyceal terminal mimic and occlude the inhibitory effect of a GPCR agonist on presynaptic $Ca^{2+}$ currents $(Ip_{Ca})$, suggesting that $G{\beta}{\gamma}$ mediates presynaptic inhibition by GPCRs. Among presynaptic GPCRs glutamate and adenosine autoreceptors play regulatory roles in transmitter release during early postnatal period when the release probability (p) is high, but these functions are lost concomitantly with a decrease in p during postnatal development.

The Effect of Application Parameter of Pulsed Direct Current on Wound Healing of Patients with Pressure Ulcer

  • Kim, Ga Yeong;Lee, Sang Bin;Moon, Ok Kon;Kim, Ji Sung;Choi, Jung Hyun;Wang, Jung San;Park, Joo Hyun;Kim, Hong Rae;Lee, Ju Hwan;Min, Kyung Ok
    • 국제물리치료학회지
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    • 제5권2호
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    • pp.752-756
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    • 2014
  • This study investigated the effects of changes to the pulsation factor of pulsed direct currents on wound healing. Patients with a pressure ulcer at a care hospital for the elderly were randomly divided into three groups: Group 1 involved the application of $100{\mu}s$ in pulse duration, 10 ms in pulse period, 100 pps in a pulsation factor, 15 mA in pulse amplitude, and polarity red+ by using pulsed direct currents; Group 2 involved a change of pulse period to 8 ms; and Group 3 received general wound management. Although there were no statistically significant differences in the changing stages of pressure ulcers among the groups, all the groups dropped in numerical stages. In the two groups to which pulsed direct currents were applied, there was a statistically significant reduction in the stages of pressure ulcers from the initial assessment to the 12-week assessment (p<.05). Even though there were no statistically significant differences in changes to the area of pressure ulcers among the groups, a statistically significant decrease was found in pulsed direct current group 2 whose pulse period was shortened (p<.05). There was no difference in the healing rate of pressure ulcers among the groups, but it made a numerical increase in pulsed direct current group 1 and group 2 and a numerical decrease in group 3. There were no significant differences in the characteristics of those who had a full recovery among the groups. Those findings indicate that pulsed direct currents have positive effects on the wound healing of patients with a pressure ulcer and that a treatment with pulsed direct currents whose pulsation factor is raised by reducing the pulse duration is especially effective.

Induction of Pacemaker Currents by DA-9701, a Prokinetic Agent, in Interstitial Cells of Cajal from Murine Small Intestine

  • Choi, Seok;Choi, Jeong June;Jun, Jae Yeoul;Koh, Jae Woong;Kim, Sang Hun;Kim, Dong Hee;Pyo, Myoung-Yun;Choi, Sangzin;Son, Jin Pub;Lee, Inki;Son, Miwon;Jin, Mirim
    • Molecules and Cells
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    • 제27권3호
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    • pp.307-312
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    • 2009
  • The interstitial cells of Cajal (ICC) are pacemaking cells required for gastrointestinal motility. The possibility of whether DA-9701, a novel prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, modulates pacemaker activities in the ICC was tested using the whole cell patch clamp technique. DA-9701 produced membrane depolarization and increased tonic inward pacemaker currents in the voltage-clamp mode. The application of flufenamic acid, a non-selective cation channel blocker, but not niflumic acid, abolished the generation of pacemaker currents induced by DA-9701. Pretreatment with a $Ca^{2+}$-free solution and thapsigargin, a $Ca^{2+}$-ATPase inhibitor in the endoplasmic reticulum, abolished the generation of pacemaker currents. In addition, the tonic inward currents were inhibited by U-73122, an active phospholipase C inhibitor, but not by $GDP-{\beta}-S$, which permanently binds G-binding proteins. Furthermore, the protein kinase C inhibitors, chelerythrine and calphostin C, did not block the DA-9701-induced pacemaker currents. These results suggest that DA-9701 might affect gastrointestinal motility by the modulation of pacemaker activity in the ICC, and the activation is associated with the non-selective cationic channels via external $Ca^{2+}$ influx, phospholipase C activation, and $Ca^{2+}$ release from internal storage in a G protein-independent and protein kinase C-independent manner.

뇌서지가 ZnO바리스터에 미치는 영향 (Effects of Lightning Surges on the Life of ZnO Varistors)

  • 이봉;이수봉;강성만;이복희
    • 대한전기학회논문지:전기물성ㆍ응용부문C
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    • 제55권5호
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    • pp.257-262
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    • 2006
  • To evaluate the change in protective levels of zinc oxide (ZnO) varistors after the surge absorption, this paper investigated the effects of the number of injection and amplitude of lightning surges on the life of ZnO varistors for low voltages. Leakage currents flowing through ZnO varistors subjected to the $8/20{\mu}s$ impulse currents under 60 Hz AC voltages were measured. The surge simulator system ECAT that can generate $8/20{\mu}s$ impulse currents with a peak short-circuit of 5 $[kA_p]$ was used. The ZnO varistor leakage current increases with exposure to impulse current, and the number of injection of $8/20{\mu}s$ impulse currents to breakdown was inversely proportional to the amplitude of the test current. Behaviors of ZnO varistor leakage currents were strongly dependent on the number of injection and amplitude of $8/20{\mu}s$ impulse currents. ZnO varistors degrade gradually when subjected to impulse current, and the resistive leakage current flowing through ZnO varistors subjected to the $8/20{\mu}s$ impulse currents under 60 Hz AC voltages was significantly increased after a certain number of injection that is dependent on the amplitude of the test impulse current. As a result, the life of ZnO varistors mainly depends on the amplitude and occurrence frequency of lightning surges.

The Effect of NO Donor on Contraction, Cytosolic $Ca^{2+}$ Level and Ionic Currents in Guinea-pig Ileal Smooth Muscle

  • Kwon, Seong-Chun;Park, Ki-Young;Ahn, Duck-Sun;Lee, Young-Ho;Kang, Bok-Soon
    • The Korean Journal of Physiology and Pharmacology
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    • 제4권1호
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    • pp.33-40
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    • 2000
  • This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1), on contraction, cytosolic $Ca^{2+}$ level $([Ca^{2+}]_i)$ and ionic currents in guinea-pig ileum. SIN-1 $(0.01{\sim}100\;{\mu}M)$ inhibited 25 mM KCl- or histamine $(10\;{\mu}M)-induced$ contraction in a concentration-dependent manner. SIN-1 reduced both the 25 mM KCl- and the histamine-stimulated increases in muscle tension in parallel with decreased $[Ca^{2+}]_i.$ Using the patch clamp technique with a holding potential of -60 mV, SIN-1 $(10\;{\mu}M)$ decreased peak Ba currents $(I_{Ba})$ by $30.9{\pm}5.4%$ (n=6) when voltage was stepped from -60 mV to +10 mV and this effect was blocked by ODQ $(1\;{\mu}M),$ a soluble guanylyl cyclase inhibitor. Cu/Zn SOD (100 U/ml), the free radical scavenger, had little effect on basal $I_{Ba},$ and SIN-1 $(10\;{\mu}M)$ inhibited peak $I_{Ba}$ by $32.4{\pm}5.8%$ (n=5) in the presence of Cu/Zn SOD. In a cell clamped at a holding-potential of -40 mV, application of $10\;{\mu}M$ histamine induced an inward current. The histamine-induced inward current was markedly and reversibly inhibited by $10\;{\mu}M$ SIN-1, and this effect was abolished by ODQ $(1\;{\mu}M).$ In addition, SIN-1 markedly increased the depolarization-activated outward $K^+$ currents in the all potential ranges. We concluded that SIN-1 inhibits smooth muscle contraction mainly by decreasing $[Ca^{2+}]_i$ resulted from the inhibition of L-type $Ca^{2+}$ channels and the inhibition of nonselective cation currents and/or by the activation of $K^+$ currents via a cGMP-dependent pathway.

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An Estimation of Tidal Currents from Satellite-tracked Drifters and its Application to the Yellow Sea

  • Lee, Se-Ok;Cho, CHeol-Ho;Kang, Sok-Kuh;Lie, Heung-Jae
    • Journal of the korean society of oceanography
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    • 제35권2호
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    • pp.65-77
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    • 2000
  • A simple but effective method has been developed for estimating diurnal and semi-diurnal tidal currents from trajectories of satellite-tracked drifters. The estimation method consists of separation of tidal current signals contained in the drifter trajectories, computation of undulations by diurnal and semi-diurnal currents, and correction of dominant diurnal and semi-diurnal tidal constituents. M$_2$ tidal currents estimated from drifter trajectories in the Yellow Sea are well consistent with those observed by moored current meters and this supports the validity of this method. We have constructed M$_2$ tidal current chart in the Yellow Sea by applying this method to available drifter trajectories collected during 1994-1998. According to this chart, M$_2$ current in the Yellow Sea rotates in the clockwise direction south of 35$^{\circ}$ 30'N but in the counterclockwise one to the north. Also it is found that the M$_2$ current is strong in the bank area northeast of the Changjiang River mouth and in the Korean coastal area, while it is weak in the deep central trough.

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전지의 연결방법에 따른 전류의 특성에 대한 초등교사들의 이해도 (The Elementary School Teachers' Understandings about the Characteristics of Currents according to the Connection Methods of Batteries in Simple Electric Circuits)

  • 현동걸;신애경
    • 한국초등과학교육학회지:초등과학교육
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    • 제33권2호
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    • pp.335-351
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    • 2014
  • The 96 elementary school teachers' the degrees of understandings about the characteristics of the currents according to the connection methods of batteries in simple electric circuits were investigated. In this study, the concepts on the characteristics of currents according to the connection methods of batteries were divided 'the learned concepts' and 'the differentiated concepts'. The characteristics of the currents in the region of the larger resistance of load than the internal resistance of a battery were called the learned concepts, they are taught in the science curriculum. While the characteristics of the currents in the region of the smaller resistance of load than the internal resistance of a battery were called the differentiated concepts, they are not exposed clearly in the science curriculum. The results obtained in this study are as follows: The average score related to the learned concepts was relatively high, while the degree of the teachers' cognitions of the internal resistance of a battery and the resistance of wires were low. Also the average score related to the differentiated concepts was very low because it seems so new to the elementary school teachers. It strongly suggests that the elementary school teachers did not understand meaningfully the characteristics of the currents related to the connections of batteries on the ground of the cognitions of the internal resistances of batteries and the resistances of loads in simple electric circuits. Hence, they might experience difficulties due to the problems occurred in relation to the connections of batteries in the elementary school science lessons.

Some High-Frequency Variability of Currents Obtained by "GeoDrifters" in the Tsushima Current Region

  • Seung, Young Ho;Park, Jong Jin;Kwon, Young-Yeon;Kim, Sung-Joon;Kim, Hong-Sun;Park, Yong-Chul
    • Ocean and Polar Research
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    • 제39권3호
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    • pp.169-179
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    • 2017
  • The "GeoDrifter" is a newly-developed surface drifter with high temporal resolution. It is the first time that high-frequency drifters have been deployed in the East/Japan Sea. The purpose of this study is to introduce the phenomena experienced by these drifters flowing along with the Tsushima Current across the East/Japan Sea, focusing on high-frequency variability, and to discuss them in comparison with previous observations. The observed basin-scale circulation of the Tsushima Current generally coincides well with the known schematic circulation. The GeoDrifter trajectories also show inertial oscillations almost everywhere in the oceanic regions of the East/Japan Sea, strong semi-diurnal tidal currents in the western part of Korea Strait, diurnal currents much stronger than semi-diurnal currents in the upstream region of the Nearshore Branch off the Japanese coast, and many warm eddies in the Yamato Basin, all comparable to the observational results reported in the previous studies. An interesting point is that the semi-diurnal tidal currents undergo a great spatial variation in the western part of the Korea Strait. The observed features that cannot be explained are, among others, strong counter-clockwise motions with oscillating period about 51 hours appearing in the upstream region of the Nearshore Branch off the Japanese coast and the different tidal behaviors between upstream and downstream regions of the latter.

전기장 변화에 따른 3차원 비정상 상태 열전달 연계 해석에 관한 연구 (A Study on the 3-D Unsteady State Heat Transfer Coupled by Conductive Currents)

  • 곽이구;김홍건
    • 한국공작기계학회논문집
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    • 제17권1호
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    • pp.29-34
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    • 2008
  • A modeling technique for the 2-way coupling of heat transfer and conduction currents has been performed to inspire a combined analytical simulation. The 3-D finite element method is used to solve steady conduction currents and heat generation in an aluminum film deposited on a silicon substrate. The model investigates the temperature in the device after the current is applied. The conservation equation of energy, the Maxwell equations for conduction currents, the unsteady state heat transfer equation and the Fourier's law for heat transfer are implemented as a bidirectionally coupled problem. It is found that the strongly coupled temperature and time dependent heat equations give a reasonable results and an explicit solving technique.