• Title/Summary/Keyword: $I_c$-B

Search Result 4,597, Processing Time 0.039 seconds

Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2

  • Choi, Jeongsuk;Buyannemekh, Dolgorsuren;Nham, Sang-Uk
    • Molecules and Cells
    • /
    • v.43 no.12
    • /
    • pp.1023-1034
    • /
    • 2020
  • Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors CR3 and CR4, also known by their leukocyte integrin family names, αMβ2 and αXβ2, respectively. Although there is general agreement that iC3b binds to the αM and αX I-domains of the respective β2-integrins, much less is known regarding the regions of iC3b contributing to the αX I-domain binding. In this study, using recombinant αX I-domain, as well as recombinant fragments of iC3b as candidate binding partners, we have identified two distinct binding moieties of iC3b for the αX I-domain. They are the C3 convertase-generated N-terminal segment of the C3b α'-chain (α'NT) and the factor I cleavage-generated N-terminal segment in the CUBf region of α-chain. Additionally, we have found that the CUBf segment is a novel binding moiety of iC3b for the αM I-domain. The CUBf segment shows about a 2-fold higher binding activity than the α'NT for αX I-domain. We also have shown the involvement of crucial acidic residues on the iC3b side of the interface and basic residues on the I-domain side.

ON CHARACTERIZATIONS OF PRÜFER v-MULTIPLICATION DOMAINS

  • Chang, Gyu Whan
    • Korean Journal of Mathematics
    • /
    • v.18 no.4
    • /
    • pp.335-342
    • /
    • 2010
  • Let D be an integral domain with quotient field K,$\mathcal{I}(D)$ be the set of nonzero ideals of D, and $w$ be the star-operation on D defined by $I_w=\{x{\in}K{\mid}xJ{\subseteq}I$ for some $J{\in}\mathcal{I}(D)$ such that J is finitely generated and $J^{-1}=D\}$. The D is called a Pr$\ddot{u}$fer $v$-multiplication domain if $(II^{-1})_w=D$ for all nonzero finitely generated ideals I of D. In this paper, we show that D is a Pr$\ddot{u}$fer $v$-multiplication domain if and only if $(A{\cap}(B+C))_w=((A{\cap}B)+(A{\cap}C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$, if and only if $(A(B{\cap}C))_w=(AB{\cap}AC)_w$ for all $A,B,C{\in}\mathcal{I}(D)$, if and only if $((A+B)(A{\cap}B))_w=(AB)_w$ for all $A,B{\in}\mathcal{I}(D)$, if and only if $((A+B):C)_w=((A:C)+(B:C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$ with C finitely generated, if and only if $((a:b)+(b:a))_w=D$ for all nonzero $a,b{\in}D$, if and only if $(A:(B{\cap}C))_w=((A:B)+(A:C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$ with B, C finitely generated.

ADMISSIBILITY AND CONNECTEDNESS IM KLEINEN IN HYPERSPACES

  • Baik, Bong Shin;Rhee, Choon Jai
    • Honam Mathematical Journal
    • /
    • v.36 no.4
    • /
    • pp.913-919
    • /
    • 2014
  • We investigate the relationships between the space X and the hyperspaces concerning admissibility and connectedness im kleinen. The following results are obtained: Let X be a Hausdorff continuum, and let A, $B{\in}C(X)$ with $A{\subset}B$. (1) If X is c.i.k. at A, then X is c.i.k. at B if and only if B is admissible. (2) If A is admissible and C(X) is c.i.k. at A, then for each open set U containing A there is a continuum K and a neighborhood V of A such that $V{\subset}IntK{\subset}K{\subset}U$. (3) If for each open subset U of X containing A, there is a continuum B in C(X) such that $A{\subset}B{\subset}U$ and X is c.i.k. at B, then X is c.i.k. at A. (4) If X is not c.i.k. at a point x of X, then there is an open set U containing x and there is a sequence $\{S_i\}^{\infty}_{i=1}$ of components of $\bar{U}$ such that $S_i{\longrightarrow}S$ where S is a nondegenerate continuum containing the point x and $S_i{\cap}S={\emptyset}$ for each i = 1, 2, ${\cdots}$.

Analysis on the Interference Effects between HAPS and NGSO Systems in the Feeder Link (HAPS와 NGSO 시스템의 Feeder Link상의 간섭분석)

  • 문승영;김봉석;강영흥
    • Proceedings of the Korea Electromagnetic Engineering Society Conference
    • /
    • 2000.11a
    • /
    • pp.34-38
    • /
    • 2000
  • In this paper, interference effects between NGSO and HAPS in the feeder link have been simulated and analyzed by means of calculating excess time percent and duration below the C/I protection ratio. As the results, in the case of HAPS interference into NGSO, it can be obtained that the lowest C/I values are 27.42dB in 50km and 12.73dB in 20Km of HAPS altitudes, respectively. And in the case of NGSO interference into HAPS, it can be obtained that the lowest C/I values are 13.94dB and 10.42dB respectively. HAPS system has more interference reception from other systems or effects more interference into other systems as its altitude is lower. Also, the lowest C/I values are appeared at difference time with its altitude.

  • PDF

DISTRIBUTIVE PROPERTIES OF ADDITION OVER MULTIPLICATION OF IDEMPOTENT MATRICES

  • Wanicharpichat, Wiwat
    • Journal of applied mathematics & informatics
    • /
    • v.29 no.5_6
    • /
    • pp.1603-1608
    • /
    • 2011
  • Let R be a ring with identity. If a, b, $c{\in}R$ such that a+b+c = 1, then the distributive laws from addition over multiplication hold in R, that is a+(bc) = (a+b)(a+c) when ab = ba, and (ab)+c = (a+c)(b+c) when ac = ca. An application to obtains, if A,B are idempotent matrices and AB = BA = 0 then there exists an idempotent matrix C such that A + BC = (A + B)(A + C), and also A + BC = (I - C)(I - B). Some other cases and applications are also presented.

A Study on the Limitations of Trade Terms in the Situtations of Kobe Earthquake -with a Special Reference to Marine Insurance- (고배대지진에 기인한 정형거래조건의 문제점)

  • 강진욱
    • The Journal of Information Technology
    • /
    • v.1 no.2
    • /
    • pp.15-24
    • /
    • 1998
  • C.I.F. and F.O.B. contracts are the chief terms used in international trade contracts. But, in recently, the multimodal transport which is based on the containerization and the improvement of air transport has been grown gradually, Regardless of theese change in international trade environment, most of the contract of sale is made by C.I.F. and F.O.B. contracts which are based on the traditional port to port transport. In other words, there are some limitation in terms of legal base in which traditional C.I.F. and F.O.B. contract is applied to the changed environment. Especially, problems arised in marine insurance which export by F.O.B. trade terms. Therefore, when the parties of the contracts of sale make an sale contracts by using the container ship and Multimodal Transport, they should use the F.C.A. and C.I.P. contracts Instead of F.O.B. and C.I.F. contracts for the transport of goods. And parties of the contracts of sale need to gain a better understanding of the characteristic of F.C.A. and C.I.P. terms and the problem of the F.C.A. and C.I.P. contracts used in the performance on international multimodal transport.

  • PDF

Fabrication of Barium Oxide Ferrite Magnet-II (바리움 훼라이트 자석의 시작 - II)

  • 백용현
    • 전기의세계
    • /
    • v.21 no.6
    • /
    • pp.17-20
    • /
    • 1972
  • The magnetic properties of Ba-Ferrite ( $M^{+2}$O.nF $e_{2}$ $O_{3}$ is highly improved under the condition of composition ratio n=4.4 when B $i_{2}$ $O_{3}$ is added to Ferrite, the adding amount and sintering temperature which affect the magnetic properties were investigated and the following results; were obtained; 1. Magnetic properties are varied with B $i_{2}$ $O_{3}$ content and singering temperature, and coercive force and residual induction can be improved with B $i_{2}$ $O_{3}$. 2. The optimal content of B $i_{2}$ $O_{3}$ amount is about 4 mol %, 3. Without the addition of B $i_{2}$ $O_{3}$, the optimal sintering temperature is about 1300.deg. C, but when 4 mol % of B $i_{2}$ $O_{3}$ is added, the optimal sintering temperature falls to the range of 900.deg. C to 1100.deg. C and it also improves magnetic properties. 4. Residual induction increases as the singering temperature is raised to 1100.deg. C. Coercive force also increased as the sintering temperature is raised to 1000.deg. C, but it rapidly decreases when sintering temperature goes beyond 1000.deg. C. 5. Only a negligible change may be noticed in the decrease of Curie temperature by the addition of about 4 mol % of B $i_{2}$ $O_{3}$.

  • PDF

NF-${\kappa}B$ Activation and cIAP Expression in Radiation-induced Cell Death of A549 Lung Cancer Cells (A549 폐암세포주의 방사선-유도성 세포사에서 NF-${\kappa}B$ 활성화 및 cIAP 발현)

  • Lee, Kye Young;Kwak, Shang-June
    • Tuberculosis and Respiratory Diseases
    • /
    • v.55 no.5
    • /
    • pp.488-498
    • /
    • 2003
  • Background : Activation of the transcription factor NF-${\kappa}B$ has been shown to protect cells from tumor necrosis factor-alpha, chemotherapy, and radiation-induced apoptosis. NF-${\kappa}B$-dependent cIAP expression is a major antiapoptotic mechanism for that. NF-${\kappa}B$ activation and cIAP expression in A549 lung cancer cells which is relatively resistant to radiation-induced cell death were investigated for the mechanism of radioresistance. Materials and methods : We used A549 lung cancer cells and Clinac 1800C linear accelerator for radiation. Cell viability test was done by MTT assay. NF-${\kappa}B$ activation was tested by luciferase reporter gene assay, Western blot for $I{\kappa}B{\alpha}$ degradation, and electromobility shift assay. For blocking ${\kappa}B$, MG132 and transfection of $I{\kappa}B{\alpha}$-superrepressor plasmid construct were used. cIAP expression was analyzed by RT-PCR and cIAP2 promoter activity was performed using luciferase assay system. Results : MTT assay showed that cytotoxicity even 48 hr after radiation in A549 cells were less than 20%. Luciferas assay demonstrated weak NF-${\kappa}B$ activation of $1.6{\pm}0.2$ fold compared to PMA-induced $3.4{\pm}0.9$ fold. Radiation-induced $I{\kappa}B{\alpha}$ degradation was observed in Western blot and NF-${\kappa}B$ DNA binding was confirmed by EMSA. However, blocking NF-${\kappa}B$ using MG132 and $I{\kappa}B{\alpha}$-superrepressor transfection did not show any sensitizing effect for radiation-induced cell death. The result of RT-PCR for cIAP1 & 2 expression was negative induction while TNF-${\alpha}$ showed strong expression for cIAP1 & 2. The cIAP2 promoter activity also did not show any change compared to positive control with TNF-${\alpha}$. Conclusion : We conclude that activation of NF-${\kappa}B$ does not determine the intrinsic radiosensitivity of cancer cells, at least for the cell lines tested in this study.

Where a Null C Fails to PF-merge

  • Hong, Sung-Shim
    • Language and Information
    • /
    • v.9 no.2
    • /
    • pp.69-83
    • /
    • 2005
  • This paper discusses the distribution of a null complementizer C, as opposed to an overt counterpart 'that', presenting empirical support both for and against the PF-merge analysis of C proposed by Boscovic and Lasnik (2003, henceafter B&L) who in turn attribute to the proposal in Pesetsky (1992) and Halle & Marantz (1993). In Section I, as a background, I discuss B&L's proposal that a null complementizer C is a PF-affix which undergoes a PF-merger operation at the PF component. In Section 2, after a brief sketch of the distribution of a null C mostly in bare-relatives, I explore the possibility of extending B&L's analysis to accomodate the null C's in the bare-relative constructions. In Section 3, I argue that despite some empirical difficulties, B&L's analysis of a null C as a PF-affix can still be maintained, if Adverb Fronting is an operation to Spec-C position. Furthermore, I propose a rule - PF Spell-Out Constraint - to account for the C-trace (i.e. that-trace) effect in relative constructions. With the PF Spell-Out Constraint and B&L's PF-merge account, the distribution of a null C can better be analyzed.

  • PDF

A Study on the Metal Feathered Trim - Focusing on the Excavated Articles from the Old Tombs in Ancient Silla, Gaya - (금속제(金屬製) 조우식(鳥羽飾)에 대(對)한 연구(硏究) - 고신라(古新羅), 가야고분(加耶古墳) 출토품(出土品)을 중심(中心)으로 -)

  • Kim, Moon-Ja
    • Journal of Fashion Business
    • /
    • v.5 no.4
    • /
    • pp.27-36
    • /
    • 2001
  • The purpose of this study is to classify of the Metal Feathered Trim in old tombs. First, Feathered Trim is 5 types, Feathered Trim I-A, Feathered Trim I-B, Feathered Trim II-A, Feathered Trim II-B, Feathered Trim II-C in according to upper part of central insert plate style. Feathered Trim I-A, I-B, II-B type was general style that was found in most of the old tombs in ancient Silla, Gaya. Feathered Trim II-A type was excavated from the only Silla tombs and II-C type was excavated from Gaya tombs. Feathered Trim I-A type was worn previous to I-B type, and II-B, C type was worn previous to II-A type. Feathered Trim 5 types was influenced by the scythe style that was 'Scythe-shaped' tail.

  • PDF