• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2000년도 추계학술대회 논문집
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• pp.131-134
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• 2000

본 논문에서는 디지털 IC회로의 입출력과 입출력 버퍼에 대한 입출력 버퍼정보 형식 모델링을 묘사하였고 입출력 버퍼의 전기적 특성을 표현하는 방법 등을 나타냈다. 또한 본 논문에서 도출한 입출력 버퍼 모델링은 CMOS와 TTL IC를 모델링 하는데 사용할 수 있는데 CMOS와 TTL IC 그리고 ROM과 RAM 메모리에 대한 입출력 버퍼 모델을 128개 정도 만들었다. 이러한 입출력 버퍼 모델은 정확한 행동(behavioral) 모델을 구성하기 위해 그리고 고속 회로의 PCB 디자인 시뮬레이션에 사용될 것이다.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2002년도 학술대회 논문집
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• pp.241-244
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• 2002

We investigated over critical current characteristics of HTS tapes fabricated by KIMM. The critical current (Ic) of the HTS tapes was 68A/cm. In order to acquire over current I-V characteristics of HTS tapes, we applied AC that is 2-7 times of Ic to these tapes. When applied AC whose peak value is twice of Ic, we found out that total resistance of HTS tapes aid not change. In case of 3 times of Ic, resistances of HTS tapes began to increase slowly. However, superconducting regions of them were maintained stably in this condition. In addition, 280 $A_{peak}$was applied, superconducting regions began to be decreased gradually. Finally, 0.62m$\Omega$ of resistance was measured in HTS tapes which was applied AC correspond to 7 times of Ic at first cycle.

• 한국생산제조학회지
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• 제8권3호
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• pp.23-27
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• 1999

A lot of electronic parts are used for recent vehicles. If electronic parts break down, it will bring passenger to fatal wound. The very representative trouble of electronic parts is a cut aluminium wire of a hybrid IC. In this study, I analyzed a cause of cut aluminium wire and the main results obtained on this study are summarized as follows; (1) The forces acting on the aluminium wire are because of thermal expansion of a resin. (2) The forces acting on the aluminium wire are obtained by the theoretical analysis and those results are agree well with those of the FEM.

• 대한기계학회논문집A
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• 제20권11호
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• pp.3491-3497
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• 1996

The work factor approach was applied to determine $G_ {IC}$ of fiber reinforced composites (AS4/3501) from a single unidirectional (0-deg) DCB specimen. Elastic work factors of DCB specimen for three different symmetrical staking sequences were derived from a simple bending theory and a finite element method. The results showed that elastic work factors calculated from both methods were comparable each other. In particular, the elastic work factor of DCB specimen with symmetrical stacking sequence is independent of stacking sequence. The $G_ {IC}$ determined from the work factor approach was compared with that determined by the compliance method. The results showed that the work factor approach and the compliance method produce comparable results of $G_ {IC}$. Thus, $G_ {IC}$ can be determined from a single DCB specimen using the work factor approach.

• 한국공작기계학회논문집
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• 제16권6호
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• pp.94-102
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• 2007

Applications of bonded dissimilar materials such as large scale integration (LSI) packages, ceramics/metal and resin/metal bonded joints, are very increasing in various industry fields. It is very important to analyze the thermal stress and stress singularity at interface edge in LSI. In order to investigate stress singularities on the bonded interface edges and delamination of die pad and resin in the IC package. In this paper, stress singularity factors(${\Gamma}_i$) and stress intensity factors($K_i$) considering thermal stress in the IC package were analyzed by using the 2-dimensional elastic boundary element method(BEM).

• Natural Product Sciences
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• 제3권1호
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• pp.19-28
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• 1997

Constitutive cyclooxygenase (COX-I) is present in cells under physiological conditions, whereas inducible cyclooxygenase (COX-II) is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions such as inflammation. We have evaluated the inhibitory effects of solvent fractionated extracts of natural products on the activities of COX-I and COX-II. Oxygen uptake COX assay was performed, as a primary screening from the tissue extracts of bovine seminal vesicles (BSV), by monitoring the initial rate of oxygen uptake using an oxygen electrode. Additionally, we evaluated plant extracts for the inhibitory effects of COX-I (in HEL cells) and COX-II (in lipopolysaccharide activated J774A.1 macrophages) using thin layer chromatography of prostanoids produced from $^{14}C-labelled$ arachidonic acid (AA). The use of such models of COX-I and COX-II assay will lead to the identification of specific inhibitors of cyclooxygenases with presumably less side effects than present therapies. Inhibitory effects of 50 kinds of plant extracts on the COX-I and COX-II activities were determined and the active fractions were found in the ethyl acetate fractions of Dryopteris crassirhizoma (roots), Amomum cardamomum (roots), Triticum aestivum (seeds), Perilla sikokiana (leaves), Anemarrhena asphodeloides (roots). Especially, the ethyl acetate fraction of Dryopteris crassirhizoma (roots), which exhibited the strong inhibition against BSV COX $(IC_{50},\;65.4\;{\mu}g/ml)$, COX-I $(IC_{50},\;8.5\;{\mu}g/ml)$, and COX-II $(IC_{50},\;17.2\;{\mu}g/ml)$, is under investigation to isolate active principles using activity-guided fractionation method.

• 약학회지
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• 제53권4호
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• pp.222-227
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• 2009

Human topoisomerase I (Topo I) plays a pivotal role in cell replication, transcription and repair and, therefore, is an important anti-cancer target. 20S-camptothecin (CPT) is a representative Topo I inhibitor. Compounds belonging to CPT family inhibit the religation step of Topo I-DNA by binding to the DNA cleavage site. Computational docking studies with Surflex-Dock were carried out to investigate the binding modes between Topo I-DNA binary complex structure and the ligand such as 20S-CPT and 9,10-substituted 20S-CPT analogues. The docking results demonstrated that most of the compounds with $IC_{50}$ value under $0.5{\mu}M$ intercalated exactly between the -1 and +1 DNA bases, deeply toward the cleavage site. The complex was stabilized by hydrogen-bonding and hydrophobic interactions with both the enzyme and the DNA. The compounds with $IC_{50}$ value above $0.5{\mu}M$ were poorly docked and did not intercalate. In addition, the docking results confirmed the overall correlation between the $IC_{50}$ values and docking scores, indicating the possible use of the modeling for the prediction of biological activity and design of potential inhibitors.

• 터널과지하공간
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• 제11권4호
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• pp.352-361
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• 2001

저온 냉각상태 및 냉각 후 상온 해빙 상태에서 암석의 모드 I 파괴인성을 BDT와 CCNBD시험편을 사용하여 구하였다. 실험 온도 범위는 상온($25^{\circ}C$)에서 -16$0^{\circ}C$로 설정하였으며 건조 및 포화된 화강암과 사암을 사용하여 파괴인성에 대한 공극수와 공극률의 영향 정도를 조사하고자 하였다. 또한 냉각 과정에서 발생할 수 있는 열균열을 조사하기 위해서 SEM 이미지 분석도 실시하였다. 냉각된 암석의 파괴인성은 온도가 하강함에 따라 증가하였다. 이러한 증가경향은 포화시료에서 더 크게 나타났으며, 포화 시료의 경우 화강암의 증가율이 사암에 비해 크게 나타났다. 냉각 후 상온 해빙 상태에서 구한 파괴인성의 경우, 냉각을 거 치지 않은 상온 상태의 파괴인성 값의 15% 이내에서 결정되었다. 냉각-해빙을 거친 시료에 대한 SEM 분석결과 화강암의 경우 조암광물간의 열팽창 차이에 의한 열균열을 확인할 수 있었으며 냉각온도가 낮을수록 균열밀도가 증가하였다.

• Journal of the Korean Wood Science and Technology
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• 제21권2호
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• pp.15-22
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• 1993

This study was carried out to investigate the fracture criterion of glulam. The mixed mode fracture of glulam was investigated by means of single edge notched specimens with various crack inclination in the longitudinal-radial plane. While fracture of wood is not completely understood, the study on linear-elastic fracture mechanics is a rational and valuable tool for studying the strength behavior of glulam. The results are summarized as follows : 1. Glue line has no effect on fracture strength. 2. There is a definite interaction between fracture toughness $K_I$ and $K_{II}$ during the mixed mode fracture of glulam. Several criterions for mixed mode failure were compared. The criterion was expressed in the following form: $(\frac{K_I}{K_{IC}})^2+(\frac{K_{II}}{K_{IIC}})^2=1$ 3. As crack inclination increases, $K_{IC}$ value and $K_{IIC}$ value decreases. The equations relating crack angle to $K_{IC}$ and $K_{IIC}$, respectively, were obtained as follows; $K_{IC}$ = -77.42${\gamma}$+153.72 ($R^2$ = 0.78) $K_{IIC}$ = -9.17${\gamma}$+34.90 ($R^2$ = 0.48)

• Bulletin of the Korean Chemical Society
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• 제32권6호
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• pp.1931-1935
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• 2011

The synthesis of carbocyclic analogues of normal nucleosides has grown exclusively since they have shown potential antiviral and antitumor activities. Radiolabeled cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-$[^{124}I]$-iodocytosine (carbocyclic d4IC) and cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-(2-$[^{124}I]$iodovinyl)cytosine(carbocyclic d4IVC) were synthesized. The synthetic route employed Pd(0)-catalyzed coupling reaction together with organotin and exchange reaction for radioiodination as key reactions. Carbocyclic $[^{124}I]$d4IC gave more than 75% radiochemical yield with greater than 95% radiochemical purity. Carbocyclic $[^{124}I]$d4IVC gave more than 80% radiochemical yield with greater than 95% radiochemical purity.