• Archives of Pharmacal Research
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• v.29 no.5
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• pp.412-417
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• 2006

Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhance the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at $37^{\circ}C$ using a Franz diffusion cell, and the ultrasound treatment was carried out for 10 h. The level of TA permeation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, $2.5W/cm^2 $), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.

• Membrane Journal
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• v.16 no.2
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• pp.115-122
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• 2006

In this study the membrane preparation and water vapor permeation of the hydrophilic polymer materials, polyaminosiloxane and polyhydroxylsiloxane, used as the coating materials for the preparation of asymmetric flat and hollow fiber membranes were investigated. And the water vapor permeation towards air permeation and their permselectivity were intensively studied for the resulting Resin A/Resin C (coupling agent) and Resin B/Resin C membranes. The water vapor permeability for 3 wt% Resin C introduced into Resin A (Resin A/Resin C) membrane was higher than for 1 and 5 wt% membranes and also water vapor permeability increased with increasing operating temperatures. In addition, at this content of 3 wt% Resin C, the absorption capability became maximum through dynamic equilibrium absorption experiment. Water vapor permeability, 43578 Barrer (1 Barrer = $10^{-10}cm^3(STP){\cdot}cm/cm^2{\cdot}s{\cdot}cmHg$) and 53000 Barrer, and the selectivity of $P(H_2O)P(Air)$, 101.3 and 102.6 were shown at 25 and $35^{\circ}C$, respectively.

• Membrane Journal
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• v.11 no.3
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• pp.116-123
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• 2001

Polyimide-silica hybrid membranes were prepared and the effect of silica content on the structural properties and the gas transport properties was studied. The hybrid membranes were obtained by the sol-gel process starting from 1,2,4,5-benzenetetracarboxylic dianhydride(PMDA), 4,4`-diamino- diphenyl oxide(ODA) and tetraethoxysilane(TEOS) in N,N` dimethylacetatmide (DMAc) solvent. The structural characterizations of the membrane were performed by FT-IR, EDX, TGA and SEM. The gas permeation experiments with ${N_2}, {O_2}, {H_2}, {CO_2}and ${CH_4}$ were carried out at the temperature of $25^{\circ}C$ and in the range of pressure from 3atm to 7atm. the hybrid membranes showed higher thermal stability than PI membranes. The silica patricles were uniformly embedded in the polyimide matrix and the size of silica particles increased with increasing silica content. The permeability coefficients of ${N_2}, {O_2}, {H_2}, {CO_2}and ${CH_4}$ increased with increasing silica content but the diffusion coefficients might appear to be a result of a solubility enhancement. In spite of the permeability enhancement, an increase in the selectivities of ${H_2}/{N_2}, ${H_2}/{O_2} and ${H_2}/{CO_2} was observed.

• Applied Chemistry for Engineering
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• v.1 no.2
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• pp.147-153
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• 1990

Poly(hydroxypropyl methacrylate) membranes and matrix devices having tertiary amine moiety were prepared by sintering method, and their permeation characteristics were investigated. The water content of this membrane was increased with decreasing the pH of the medium. The permeability of this membrane was increased with decreasing the sintering pressure. Using sintered matrix device 'burst effect' was found at the early stage, and initial insulin release of glucose oxidase immobilized matrix device could be controlled by glucose concentration of the solution.

• Membrane Journal
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• v.13 no.3
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• pp.154-161
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• 2003

We measured the permeation characteristics of water with the hydrophobic PTFE membranes dependent on water temperature to confirm the separation of oxygen isotopes using Air Gap Membrane Distillation (AGMD) and Vacuum Enhanced Membrane Distillation (VEMD). Isotopic concentrations of $H_2^{16}O$ and $H_2^{18}O$ of the permeated water vapor were measured by Diode Laser Absorption Spectroscopy. Concentrations of the heavy oxygen isotopes in the permeated water vapor were decreased. Isotope separation coefficients for the hydrophobic PTFE membranes were 1.004∼1.01 depending on the experimental conditions. We observed the effects of air in membrane pores on the oxygen isotope separation. Isotope separation coefficients for the hydrophobic PTFE membranes without air in pores are higher than those for the membrane with air in pores.

• Proceedings of the Membrane Society of Korea Conference
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• 1997.04b
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• pp.13-16
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• 1997

The permeation, solution and diffusion of simple gases ($He, H_2, O_2, N_2$ and CH$_4$) and condensible vapers($CO_2, SO_2, C_2H_4$ and $C_3H_8$), and the mixed gases ($O_2/N_2$ mixtures and $CO_2/CH_4$ mixtures) through composite membrane was studied. Composit membranes were made by deposition of aromatic fluorocarbons onto polymer substrams of porous Celgard in a microwave discharge. In the both cases of simple gases and condensible vapors, as the kinetic molecular diameter of the permeant molecules increased, the permeability decreased. However, when the kinetic molecular dimemr are similar, the condensible vapors showed higher permeabilities than that of permanent gases. The vapor solubility increased with increasing critical temperature of the vapors. However, in the case of propane, despite its high critical temperature, it showed lower solubility than other vapors. The vapor diffusivity decreased with increasing kinetic diameter of the molecule. Compared to conventional polymers, the plasma polymers showed much lower values for vapor diffusivities. The pressure of the permeant did not affect the permeability. The permeability was also not affected by the composition in cases of mixed gases.

• Proceedings of the Membrane Society of Korea Conference
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• 1991.10a
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• pp.29-33
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• 1991

Alumina UF membranes were prepared by sol-gel process and their gas permeabilities were characterized. Alumina MF membrane with average pore diameter about 0.12$\mu$m and tubular shape was used as a support. Gas permeation measurements of helium and nitrogen gas exhibited the permeabilities of 1.58 $\times$ 10E-6 and $0.63 \times 10E-6 cc\cdot cm(STP)/cm^2\cdot sec \cdot cmHg$, respectively. The permeability ratio was 2.5. This means the gas permeation is fully governed by knudsen diffusion mechanism.

• Membrane Journal
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• v.32 no.6
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• pp.456-464
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• 2022

Hydrogen permeation performance was analyzed by manufacturing Pd and Pd-Cu membranes through electroless plating. As a support for the Pd and Pd-Cu membranes, α-Al₂O₃ ceramic hollow fiber were used. Pd-Cu membrane was manufactured through sequential electroless plating, and then annealing was performed at 500°C, for 18 h in a hydrogen atmosphere to make Pd and Cu alloy. After annealing, the Pd-Cu membrane confirmed that the alloy was formed through EDS (Energy Dispersive X-ray Spectroscopy) and XRD (X-ray Diffraction) analysis. In addition, the thickness of the Pd and Pd-Cu plating layers were measured to be about 3.21 and 3.72 µm, respectively, through SEM (Scanning Electron Microscope) analysis. Hydrogen permeation performance was tested for hydrogen permeation in the range of 350~450°C and 1~4 bar in hydrogen single gas and mixed gas (H₂, N₂). In a single hydrogen gas, Pd and Pd-Cu membranes have flux of up to 54.42 and 67.17 ml/cm²⋅ min at 450 °C and 4 bar. In the mixed gas, it was confirmed that the separation factors of 1308 and 453 were obtained under the conditions of 450 °C and 4 bar.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.699-706
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• 2018

The permeation properties of plasma polymer membranes were studied for permanent gases such as He, $H_2$, $O_2$, $N_2$, $CH_4$ and condensable vapors such as $CO_2$, $C_2H_4$, $C_3H_8$. The plasma polymers were prepared by the discharge of microwave or radiofrequency(RF) wave. Hexamethyldisiloxane (HMDS) vapor was used as a monomer for plasma polymerization. In HMDS plasma-polymerized membranes prepared under microwave discharge, the permeability coefficient was dependent of the kinetic molecular diameter of the permeate gases. Additionally the membranes showed higher $O_2/N_2$ permselectivity compared to the plasma polymers from radiofrequency discharge. On the contrary, in the HMDS plasma-polymerized membranes prepared under radiofrequency discharge, the permeability coefficient was dependent of the critical temperature of the permeant gases. The membranes showed high selectivities of $C_2H_4$ and $C_3H_8$ over $N_2$. The permeability coefficient of plasma polymerized membranes prepared under microwave discharge was dependent of the molecular diameter of permeant gases because of high crosslinking density of the membrane. However, the crosslinking density of the plasma polymerized membranes prepared under RF discharge was lower because the energy density of RF wave is weaker than that of microwave. Hence, the permeability of RF plasma polymerized membranes became dependent of the critical temperature rather than molecular diameter of the gases.

• Membrane Journal
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• v.22 no.2
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• pp.142-154
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• 2012

In order to remove $CO_2$ from the DME plant process, we investigated the composite membrane with rubbery polymers as the separation layer and its separation performance of $CO_2$ and $H_2$. Hollow fiber membranes for supporting layer were prepared by solution spinning method. In case of using PDMS as a separation layer, the composite membranes showed the permeation rates of $CO_2$ were over 300 GPU and minimum $CO_2/H_2$ selectivitties were 4.3 and in case of using PEBAX as a separation layer, the composite membranes showed the permeation rates of $CO_2$ were over 120 GPU and minimum $CO_2/H_2$ selectivities were 5.