• Title/Summary/Keyword: $GT_1$

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In vitro cytotoxicity and in vivo acute toxicity of selected polysaccharide hydrogels as pharmaceutical excipients

  • Kulkarni GT;Gowthanarajan K;Raghu C;Ashok G;Vijayan P
    • Advances in Traditional Medicine
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    • v.5 no.1
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    • pp.29-36
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    • 2005
  • Polysaccharide hydrogels constitute a structurally diverse class of biological macromolecules with a wide range of physicochemical properties. They also constitute important members of the family of industrial water-soluble polymers. They find application in Pharmacy as binders, disintegrants, suspending, emulsifying and sustaining agents. According to the International Pharmaceutical Excipients Council (IPEC), an excipient must have an established safety profile. Hence, in the present study, in vitro cytotoxicity on Vero and HEp-2 cell lines, and in vivo acute toxicity in rats were carried out to establish the safety of polysaccharide hydrogels from the seeds of Plantago ovata and Ocimum basilicum. The in vitro cytotoxicity was determined by MTT and SRB assays. In the in vivo acute toxicity, the effects of three different doses of hydrogels (100, 200 and 400 mg/kg body weight) on food and water intake, body weight, biochemical and hematological parameters were studied. The results of in vitro did not show any cytotoxicity on both the cell lines used. In the in vivo acute toxicity, the hydrogels did not show any toxic symptoms in all three dose levels. This establishes the safety of the selected hydrogels. Hence, they can be used as excipients in pharmaceutical dosage forms.

Implementation of a Service Data Aggregator Service based on OGSA By Using Globes Toolkit V.3 (Globus Tookit V.3를 사용한 OGSA 기반 서비스 데이터 수집기 서비스 구현)

  • Kang Yun-Hee
    • Journal of Digital Contents Society
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    • v.6 no.1
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    • pp.1-5
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    • 2005
  • This paper describes the main characteristics of Grid Services based on OGSA and a Grid service for aggregating service data element(SDE)s. In order to build a Grid Service, it needs to consider a systematic building approach from the high-level software architecture that represents the main system components and their interactions. The purpose of this paper is to design and implement an extended service data aggregator service in which SDE is a basic unit for collecting resource information. A GT3 based service data aggregator service is extended to apply the multiple collections based storage scheme for maintaining persistently SDEs with a XML DBMS Xindice. To provide efficient aggregating service for service data elements, which is running under wide area environment like Internet, the aggregator service is asynchronously operated by notification mechanism.

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A Study on the National Spatial Data Infrastructure of U.S.A

  • Koh, June-Hwan
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.25 no.6_1
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    • pp.485-497
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    • 2007
  • By the rapid development of Information Communication Technology (ICT) and Geo-spatial Technology (GT) and the increased usage of spatial data for planning and infrastructure management, the National Geographic Information System (NGIS) for more efficient and effective utilization of spatial information has been developed by the central government in Korea since 1995. NGIS is the base of Spatial Data Infrastructure (SDI). SDI is developed as one of National Information Infrastructures (NII). Among the hierarchy of SDI, National Spatial Data Infrastructure (NSDI) has very important role in the success of SDI development. Many research articles show that the USA's NSDI initiatives, development strategy have been strongly influenced all over the world. In these viewpoints, to propose the future directions of Korean NGIS, the development of NSDI strategy of USA is reviewed by literature through published book and internet resources. The conclusions of this study are as follow: 1) top-down and bottom-up approach are needed for integrated data sharing and standardization. 2) the creative and evolutionary vision and strategy has to be suggested. 3) the training program and lecture material has to be developed and diffused to the users and providers of spatial data. 4) governance system has to be built for NSDI evaluation. 5) the formation of geo-spatial forum to discuss the spatial-related problems and make research agenda, etc.

Bearing capacity factor Nγ for a rough conical footing

  • Khatri, Vishwas N.;Kumar, Jyant
    • Geomechanics and Engineering
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    • v.1 no.3
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    • pp.205-218
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    • 2009
  • The bearing capacity factor $N_{\gamma}$ is computed for a rough conical footing placed over horizontal ground surface. The axisymmetric lower bound limit analysis formulation, in combination with finite elements and linear programming, proposed recently by the authors is used in this study. The variation of $N_{\gamma}$ with cone apex angle (${\beta}$), in a range of $30^{\circ}-180^{\circ}$, is obtained for different values of ${\phi}$; where ${\phi}$ is soil friction angle. For ${\phi}<30^{\circ}$, the magnitude of $N_{\gamma}$ is found to decrease continuously with an increase in ${\beta}$ from $30^{\circ}$ to $180^{\circ}$. On the other hand, for ${\phi}>30^{\circ}$, the minimum magnitude of $N_{\gamma}$ is found to occur generally between ${\beta}=120^{\circ}$ and ${\beta}=150^{\circ}$. In all the cases, it is noticed that the magnitude of $N_{\gamma}$ becomes maximum for ${\beta}=30^{\circ}$. For a given diameter of the cone, the area of the plastic zone reduces generally with an increase in ${\beta}$. The obtained values of $N_{\gamma}$ are found to compare quite well with those available in literature.

Power Modeling Approach for GPU Source Program

  • Li, Junke;Guo, Bing;Shen, Yan;Li, Deguang;Huang, Yanhui
    • Journal of Electrical Engineering and Technology
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    • v.13 no.1
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    • pp.181-191
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    • 2018
  • Rapid development of information technology makes our environment become smarter and massive high performance computers are providing powerful computing for that. Graphics Processing Unit (GPU) as a typical high performance component is being widely used for both graphics and general-purpose applications. Although it can greatly improve computing power, it also delivers significant power consumption and need sufficient power supplies. To make high performance computing more sustainable, the important step is to measure it. Current power technologies for GPU have some drawbacks, such as they are not applicable for power estimation at the early stage. In this article, we present a novel power technology to correlate power consumption and the characteristics at the programmer perspective, and then to estimate power consumption of source program without prerunning. We conduct experiments on Nvidia's GT740 platform; the results show that our power model is more accurately than regression model and has an average error of 2.34% and the maximum error of 9.65%.

Prediction of the Tritium Behavior in Very High Temperature Gas Cooled Reactor Using TRITGO (TRITGO 코드를 이용한 초고온가스로 (VHTR) 삼중 수소 거동 예측)

  • Park, Jong-Hwa;Park, Ik-Kyu;Lee, Won-Jae
    • Journal of Radiation Protection and Research
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    • v.33 no.3
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    • pp.113-120
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    • 2008
  • In this study, The TRITGO code was introduced, which can predict the amount of tritium production, it's transport, removal, distribution and the level of contamination for the produced hydrogen by the tritium on the VHTR (very high temperature gas cooled reactor). The TRITGO code was improved so that the permeation to the IS Iodine Sulfide) loop for producing the hydrogen can be simulated. The contamination level of the produced hydrogen by the tritium was predicted by the improved code for the VHTR with 600MW thermal power. The contamination level for the produced hydrogen by tritium was predicted as 0.055 Bq/$H_2-g$. This level is three order of lower than the regulation value of 56 Bq/$H_2-g$ from Japan. From this study, the following results were obtained. it is important that the fuel coating (SiC layer) should be kept intact to prevent the tritium from releasing. Also it is necessary that the level of impurity such as 3He and Li in the helium coolant and the reflector consisting of the graphite should be kept as low as possible. It was found that the capacity of the purification system for filtering the impurities directly from the coolant will be the important design parameter.

Antioxidative and Hair-growth-promotion Effects of a Fermented Compound Composed of Five Materials (발효 5종 혼합물의 항산화 및 모발 성장 촉진 효과)

  • Lee, Ha Neul;Ha, Bae Jin
    • Journal of Life Science
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    • v.28 no.6
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    • pp.663-670
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    • 2018
  • This study was performed to confirm the antioxidative and hair-growth-promotion effects of a fermented compound composed of five materials, namely Allium cepa, Cucurbita spp., Glycine max Merr., Pinus sylvestris leaf, and Sesamum indicum. An additional compound composed of two materials was composed of Allium cepa and Cucurbita spp. Antioxidative effects were measured based on DPPH radical-scavenging activity and total flavonoid content. Fermented 5-type natural compounds (5NC) showed higher DPPH radical-scavenging activity and flavonoid content than those of fermented 2-type natural compounds (2NC). Hair-growth promotion was demonstrated in vivo. Alkaline phosphatase (ALP), oid contentontenteptidase phospactivity, and macroscopic observation were measured. Experimental animals were divided into four groups based on the samples they were administered: water, pansildil (P-CON), 5NC, and 2NC. Samples were administered orally once a day at a fixed time for four weeks. Both ALP and ${\gamma}eeksactivity$ increased in the 5NC group compared with the 2NC group. In macroscopic observation, the P-CON group grew the most and were most similar to the state before shaving. The 5NC group grew hair similar to the P-CON group. In all the results, the 5NC group showed greater antioxidative and hair-growth-promotion effects than the 2NC group. Consequently, 5NC could be used as an ingredient for hair-growth promotion.

Performance Simulation of Motorcycle Engine Exhaust Heat Recovery System using Thermoelectric Element (열전소자를 이용한 모터사이클용 엔진 배기 폐열 회수 시스템 성능 해석)

  • Lee, Moo-Yeon;Kim, Kihyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.2
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    • pp.695-701
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    • 2018
  • Research into exhaust heat recovery has been actively carried out to improve the thermal efficiency of internal combustion engines. In this study, the performance of thermoelectric generation from exhaust heat recovery for motorcycle engines was analyzed by 1-D thermo-fluid simulation. GT-SUITE, which was developed by Gamma Tech., was used for the simulation of the internal combustion engine and thermoelectric generation system. The basic performance of the engine was analyzed in the range of engine speed of 1000~7000 rpm and engine load of 0~100%. The ratio of exhaust heat energy to fuel chemical energy was found to be about 40~60%. A combined simulation of the engine model and thermoelectric generation model was carried out to analyze the voltage, current and power generated by the thermoelectric material. The generation characteristics of the thermoelectric material was dominantly affected by the exhaust gas temperature. The maximum generated power of the current thermoelectric generation system was found to be about 2.2% of the total exhaust heat energy. The design optimization of the thermoelectric generation system will be carried out to maximize its power generation and economic feasibility.

Varietal Difference of Protein Content and Amino Acid Composition in Sesame (참깨품종의 단백질함량과 아미노산 조성)

  • Seong, Nak-Sul;Lee, Jung-Il;Kang, Chul-Whan;Park, Rae-Kyeong;Chae, Young-Am
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.35 no.5
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    • pp.440-448
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    • 1990
  • To obtain the basic information an seed quality improvement in sesame, protein content of 114 varieties and amino acid composition of 12 varieties was analyzed. Protein content showed the vaietal difference ranged 20.6-30.2% and the mean was 24.72%. The highest variety in protein content was PI158066 (30.2%) originated from U.S.A. Protein content of Korean local varieties were highest among original group analyzed. Seed coat texture and seed coat color affected to protein content so, smooth type was higher than rough type in protein content, and black seeded varieties showed the hight protein content. Amino-acid composition of sesame was uneque in balance and higher than FAO reference. Total amino-acid of variety PI258372 was highest as 25.03%. Essential amino-acid (EAA) /total amino-acid(TAA) ratio of sesame was higher as 42-58.2% than soybean, corn, rice, peanut. Korean local variet 'Samcheck' showed best quality in amino-acid composition as 58.2% in EAA/TAA ratio with high tyrocin and lysine. Total amino acid content was high in order of Korean local '||'&'||'gt; introduced '||'&'||'gt; Korean bred varieties.

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The Effects of Gardeniae Fructus Aqua-Acupuncture on Liver Injury of Rats Induced by CCI4 (치자약침(梔子藥鍼)이 실험적(實驗的) 백서(白鼠)의 간손상(肝損傷)에 미치는 영향(影響))

  • Park, Hee-Soo;Park, Joung-Hyun
    • Journal of Pharmacopuncture
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    • v.3 no.2
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    • pp.55-77
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    • 2000
  • This is the study of the effects of Aqua-acupuncture with Gardeniae Fructus on thc recovery of rat's liver which was damaged by 0.3ml/ea of $CCI_4$. Rats were divided into 4 groups; Normal-group(None treated group), Control-group(Not treated after $CCI_4$-intoxicated), Exp. I(Treated with Saline Aqua-acupuncture after $CCI_4$-intoxicated) and Exp. ll(Treated with Gardeniae Fructus Aqua-acupuncture after $CCI_4$-intoxicated). Biochemical assays for each serum enzyme activities of AST, ALT, Albumin, LDH, ${\gamma}$-GT, TG and Total cholesterol were performed. The results were summarized as follows: 1. AST activities in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In companson with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group *The professor of Dept. of Acupuncture & Moxibustion, 2. At T activities in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In com pan son with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated worked effectively to rat's damaged liver. 3. Albumin in serum increased in the Gardeniae Fructus Aqua- acupurkture treated group after $CCI_4$-intoxicated. 4. LDH in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after CClcintox icated, the Gardeniae Fructus Aqua acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. 5. ${\gamma}$-GT In serum significantly decreased In the Gardeniae Fructus Aqua-acupuncture trea ted group after $CCI_4$-intoxicated. In compan son with Saline-treated group after $CCI_4$-intoxicated, the Crardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated was not recognized significantly. 6. TG in serum significantly decreased in the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua -acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. 7. Total cholesterol in serum decreased in the Gardenias Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated. In comparison with Saline-treated group after $CCI_4$-intoxicated, the Gardeniae Fructus Aqua-acupuncture treated group after $CCI_4$-intoxicated worked highly effectively to rat's damaged liver. The results from ahove show that the Gardeniae Fructus Aqua- acupuncture has highly effects on the damaged liver caused by $CCI_4$. Therefore it is expected that the Gardeniae Fructus Aqua- acupuncture could be used to cure the damaged liver.