• 제목/요약/키워드: $F_{ST}$

검색결과 820건 처리시간 0.025초

Comparing Perceptions, Determinants, and Needs of Patients, Family Members, Nurses, and Physicians When Making Life-Sustaining Treatment Decisions for Patients with Hematologic Malignancies

  • Kim, Semi;Ham, Eun Hye;Kim, Dong Yeon;Jang, Seung Nam;Kim, Min kyeong;Choi, Hyun Ah;Cho, Yun A;Lee, Seung A;Yun, Min Jeong
    • Journal of Hospice and Palliative Care
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    • 제25권1호
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    • pp.12-24
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    • 2022
  • Purpose: This descriptive study compared the perceptions, determinants, and needs of patients, family members, nurses, and physicians regarding life-sustaining treatment decisions for patients with hematologic malignancies in the hematology-oncology department of a tertiary hospital in Seoul, Korea. Methods: In total, 147 subjects were recruited, gave written consent, and provided data by completing a structured questionnaire. Data were analyzed using analysis of variance, the chi-square test, and the Fisher exact test. Results: Nurses (F=3.35) and physicians (F=3.57) showed significantly greater familiarity with the Act on Decisions on Life-Sustaining Treatment than patients (F=2.69) and family members (F=2.59); (F=19.58, P<0.001). Many respondents, including 19 (51.4%) family members, 16 (43.2%) physicians, and 11 (29.7%) nurses, agreed that the patient's opinion had the greatest effect when making life-sustaining treatment decisions. Twelve (33.3%) patients answered that mental, physical, and financial burdens were the most important factors in life-sustaining treatment decisions, and there was a significant difference among the four groups (P<0.001). Twenty-four patients (66.7%), 27 (73.0%) family members, and 21(56.8%) nurses answered that physicians were the most appropriate people to provide information regarding life-sustaining treatment decisions. Unexpectedly, 19 (51.4%) physicians answered that hospice nurse practitioners were the most appropriate people to talk to about life-sustaining treatment (P<0.001). Conclusion: It is of utmost importance that the patient and physician determine when life-sustaining treatment should be withdrawn, with the patient making the ultimate decision. Doctors and nurses have the responsibility to provide detailed information. The goal of end-of-life planning is to ensure patients' dignity and respect their values.

Effect of Electrical Muscle Stimulation Training With and Without Superimposed Voluntary Contraction on Rectus Femoris and Vastus Intermedius Thickness and Knee Extension Strength

  • Weon, Young-soo;Kim, Jun-hee;Gwak, Gyeong-tae;Lee, Do-eun;Kwon, Oh-yun
    • 한국전문물리치료학회지
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    • 제29권2호
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    • pp.140-146
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    • 2022
  • Background: The superimposed technique (ST) involves the application of electrical muscle stimulation (EMS) during voluntary muscle action. The physiological effects attributed to each stimulus may be accumulated by the ST. Although various EMS devices for the quadriceps muscle are being marketed to the general public, there is still a lack of research on whether ST training can provide significant advantages for improving quadriceps muscle strength or thickness compared with EMS alone. Objective: To compare the effects of eight weeks of ST and EMS on the thicknesses of the rectus femoris (RF) and vastus intermedius (VI) muscles and knee extension strength. Methods: Thirty healthy subjects were recruited and randomly assigned to either the ST or EMS groups. The participants underwent ST or EMS training for eight weeks. In all participants, the thicknesses of the RF and VI muscles were measured before and after the 8-week intervention by ultrasonography, and quadriceps muscle strength was measured using the Smart KEMA tension sensor (KOREATECH Co., Ltd.). Results: There were significant differences in the pre- and post-intervention thicknesses of the RF and VI muscles as well as the quadriceps muscle strength in both groups (p < 0.05). RF thickness was significantly greater in the ST group (F = 4.294, p = 0.048), but there was no significant difference in VI thickness (F = 0.234, p = 0.632) or knee extension strength (F = 0.775, p = 0.386). Conclusion: EMS can be used to improve quadriceps muscle strength and RF and VI muscle thickness, and ST can be used to improve RF thickness in the context of athletic training and fitness.

산란계종의 잡종강세 이용을 위한 유전학적 기초연구와 우량교배조합 선발에 관한 연구 (Estimation of Genetic Variations and Selection of Superior Lines from Diallel Crosses in Layer Chicken)

  • 오봉국;한재용;손시환;박태진
    • 한국가금학회지
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    • 제13권1호
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    • pp.1-14
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    • 1986
  • 본 연구에서는 산란종계 육종개발에 필요한 기초자료를 얻기 위하여 산란종계 6계통을 양면교잡시켜 생산된 후대 3,759수를 가지고 교잡에 의한 잡종강세효과와 결합능력을 추정하였다. 공시계는 국립종축원 대전지원에서 보유하고 있는 White LKeghorn종 6계통에서 생산된 36개 조합의 양면교잡종을 이용하여 1984년 5월 11일부터 1985년 9월23일까지 500일간 수행하였으며, 수정율, 부화율, 육추율, 유성율, 성계생존율, 초산일령, 초산시 체중, 평규란중, 생존계산란율, 산란지수 및 사료요구율 등을 조사하였다. 조사된 각 형질에 대한 기록을 분석하여 교잡에 의한 잡종강세효과, 일반결합능력, 특수결합능력, 상반교잡효과 등을 추정하였다. 분석방법은 Griffing(1956)의 Model I 모형을 이용하여 추정하였다. 본 연구에서 얻어진 결과를 요약하면 다음과 같다. 1. 조사된 형질의 일반능력은 수정율이 94.76%, 부화율이 74.05%, 육추율이 97.47%, 육성율이 99.72%, 생존율이 93.81%, 초산일령이 150일, 초산시체량이 1,505g, 평균란중이 60.08g, 생존계산란율이 77.11%, 산란지수가 269.8개, 사료요구율이 2.44로 나타났다. 2. 잡종강세의 크기는 수정율에서 -1.66%로 부의 방향으로 나타났으며 부화율에서 9.58%, 육추율에서 0.26%, 생존율에서 1.83%, 초산일령에서 -3.87%, 초산시체중에서 3.63%, 평균란중에서 0.96, 산란율에서 4.23%, 산란지수에서 6.4%, 그리고 사료요구율에서 -0.85%로 나타나 수정율과 체중을 제외한 모든 형질에서 바람직한 개량방향으로 잡종강세효과를 보여 주었으며, 비교적 유전력이 낮은 부화율, 사란능력에서는 잡종강세효과가 컸고, 유전력이 비교적 높은 란중은 잡종강세효과가 적었다. 3. 결합능력의 분석에서 얻어진 결과는 다음과 같다. 1)수정율 일반결합능력, 특수결합능력 및 상반교잡효과는 중요하지 않은 것으로 나타났으며, 수정율은 유전적 요인보다는 환경적인 요인에 의해 영향을 많이 받는 것으로 나타났다. 부화율에서는 일반결합능력이 큰 비중을 차지하였으며 특히 K와 V계통의 상가적 유전효과가 크게 추정되었다. 2) 사료요구율과 평균란중은 일반결합능력이 특히 중요하였으며 특수결합능력과 상반교잡효과도 중요하게 나타났다. 사료요구율은 F, K, B 계통에서 우수하였으며, 란중은 F, B 계통이 우수하게 나타났다. 4) 초산일령은 일반결합능력, 특수결합능력 및 상반교잡효과가 모두 중요하게 나타났으며, V$\times$E, F$\times$K, B$\times$F의 교배조합이 우수하였고, 초산시체중은 일반결합능력이 특히 중요하게 나타났으며 특수결합능력과 상반교잡효과도 중요하게 나타났다. 초산시체중을 가벼운 쪽으로 개량하고자 할 때 K, F, E 계통이 우수하였다. 5) 산란율과 산란지수는 일반결합능력, 특수결합능력, 상반교잡효과가 모두 중요하였으며, F$\times$K, $A\times$K, $K\times$A 조합에서 우수하게 나타났다. 4. 일반적으로 일반결합능력이 중요하게 나타난 형질은 부화율, 초산시체중, 평균란중, 산란율, 산란지수, 사료요구율이었고 특수결합능력이 중요하게 나타난 형질은 육추율, 성계생존율, 초산일령, 산란율, 산란지수였으며, 상반교잡효과가 중요하였던 형질은 초산일령이었다.

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참깨 역병(Phytophthora nicotianae var. parasitica) 및 시들음병(Fusarium oxysporum f. sg. vasinfectum)에 길항적인 Streptomyces spp.의 분류 동정 (Identification of Antagonistic Streptomyces Species on Phytophthora nicotianae var. parasitica and Fusarium oxysporum sporum f. sg. vasinfectum Causing Sesame Wilt and Blight)

  • 정봉구;서상오
    • 한국균학회지
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    • 제20권1호
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    • pp.65-71
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    • 1992
  • 참깨 역병(疫病) 및 시들음병에 길항효과(拮抗效果)가 우수(優秀)한 2균주(菌株)에 대하여 형태적(形態的), 배양적(培養的) 및 생리적(生理的) 특징(特徵)에 근거하여 동정하였다. 형태적(形態的)특정으로서 포자(胞子)사슬모양이 공시균(供試菌) St-11은 꾸불꾸불한 모양(Rectus-flexibilis)인 반면(反面) 분리균주(分離菌株) St-20은 고리모양(Rectinaculum-apertum)이었다. 포자(胞子)의 세포벽표면(細胞壁表面)의 모양은 St-11이 매끄러운 모양(Smooth form)이었으나 St-20은 바늘모양(Spiny form)이었다. 배양적(培養的) 특징(特徵)으로서 기중(氣中) 균사체(菌絲體)의 색깔은 뒷면과 함께 모두 회색계통(灰色系統)이었으며 대체로 공시배지(供試培地)에서 균(菌)의 생장(生長)은 양호(良好)하였다. Soluble pigment 는 공시균주(供試菌株) St-11과 St-20 모두에서 형성(形成)되지 않았다. 공시균(供試菌) St-11은 의 분해능(分解能)과 Gelatin 액화능(液化能)은 음성 반응을 보인 반면 St-20은 전분(澱粉)의 분해능(分解能)은 양성반응, Gelatin 액화능(液化能)은 음성이었다. 이상의 여러 시험결과에 따라 공시균주 St-11은 Streptomyces bikiniensis로 St-20 은 Streptomyces echinoruber로 동정하였다.

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부산광역시 온천변 식물상의 군집구조에 관한 연구 (The Community Structure of Plant at the Edge of the Oncheon River in Busan)

  • 문성기;허만규
    • 생명과학회지
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    • 제18권7호
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    • pp.924-930
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    • 2008
  • 군집구조란 군집에서 종 수와 이들 종 간 개체들의 분포 양상을 말한다. 본 연구는 다른 지점에서 생태학적 생물종다양성의 통계학적 방법으로 종이 임의로 분포하는지 평가하였다. 이를 위해 부산광역시 도심을 관류하는 온천천의 상, 중, 하류의 다섯 개의 지점을 선정하여 각 지점당 양쪽에 위치한 10개 정점에서 종수를 파악하였다. 95분류군(85종, 9변종, 1품종)이 온천천변에 분포하였다. 다섯 지점에 대해 종수는 유의하게 차이를 나타내었다(F=7.75, P<0.01). Shannon-Wiener의 정보지수는 정점간 유의한 차이를 나타내었으며(F=4.12, p<0.05), 지점 St.1이 다른 지점(St. 2는 2.206, St. 3는2.116, St. 4는 2.069, St. 5는 0.637)에 비해 가장 높았다(2.380). 풍부도 지수에서 R1값은 온천천의 상류에서 하류로 갈수록 낮았다. 공존하는 근연속내 식물종의 풍부도를 근연관계가 먼 그룹과 낮은 그룹 간 분석하는 새로운 군집구조 분석법을 시도하였다. 근연속과 그렇지 않은 속의 쌍 분포도에서 정점 간 유의한 차이를 역시 나타내었다. 축적값은 x=0.85일 때 가장 유의한 차이를 나타내었다.

Detecting Activations in the Acupuncture Stimulation like Event-Related fMRI using ICA Method

  • Kim, Jeong-Seok;Choe, Bo-Young;Kang, Sei-Kwon;Chung, Sung-Taek;Lee, Hyoung-Koo;Suh, Tae-Suk
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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    • pp.101-101
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    • 2002
  • PURPOSE: To separate activations from other physiological and artifactual component that contribute to functional MRI(fMRI) recordings and detect one consistently task-related component activated during the acupuncture stimulation, we try to take the ICA(Independent Component Analysis) method.

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A Comparison of Dizziness Handicap Inventory Scores with Stability Index and Fourier Harmony Index in Healthy Individuals

  • Sang-Seok Yeo;Heun-Jae Ryu
    • The Journal of Korean Physical Therapy
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    • 제35권4호
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    • pp.105-110
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    • 2023
  • Purpose: The purpose of this study was to determine whether the degree of dizziness affects static balance due to the disruption or absence of the senses involved in balance. To this end, the correlation between the Dizziness Handicap Inventory (DHI), which objectively evaluates dizziness, the Fourier Index (FI; Frequency bands of postural oscillation, F1, F2-4, F5-6, F7-8) and the Stability Index (ST), which evaluates static balance ability, were examined. Methods: This study investigated balance and dizziness issues in 30 healthy young adults. Participants underwent multiple tests like the DHI and tetra-ataxiometric posturography (Tetrax) under different conditions (eyes open/closed, standing on a foam-rubber pillow, and with the head in various orientations). Results: We found that F1 exhibited a weak positive correlation with dizziness under normal conditions, as well as when the eyes were closed (r=0.396, p<0.05) and the head was tilted back (r=0.375, p<0.05). Meanwhile, F5-6 showed a moderate positive correlation with dizziness in both head-back (HB: r=0.471, p<0.05) and head-forward postures (r=0.404, p<0.05). Lastly, both F7-8 and ST demonstrated a moderate positive correlation with dizziness when the head was in a forward posture (F7-8: r=0.483; ST: r=0.403, p<0.05). Conclusion: The study results indicate that the severity of dizziness affects sensory systems and balance. It also suggests that head movements, especially forward and backward, further stimulate the vestibular system, intensifying dizziness, and balance problems in affected individuals.

정신분열병 환자의 작동기억 이상에 대한 기능적 자기공명영상 연구 (Working Memory Deficits in Patients with Schizophrenia:fMRI Investigation)

  • 박여진;김태석;노사봉;배치운;김정진;이수정;이철;백인호;이창욱
    • 생물정신의학
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    • 제12권1호
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    • pp.32-41
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    • 2005
  • Objective:Impaired processing of working memory is one of the cognitive deficits seen in patients with schizophrenia. This aimed at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the control subjects. Method:Fourteen patients with schizophrenia and 12 healthy volunteers were recruited in this study. Functional magnetic resonance imaging(fMRI) was used to assess cortical activities during the performance of a 2-back visual working memory paradigm using the Korean alphabet as mnemonic content. Results:Group analysis revealed that left lateral prefrontal cortex and right parietal lobule showed decreased cortical activities in the patient group. On the other hand, an increased activation in left superior and middle frontal gyrus, left middle temporal gyrus, right cuneus, both occipital lobes, right fusiform gyrus and right cingulate gyrus. The activation in left anterior lobe and both declive of cerebellum was also increased. Conclusions:This study showed a decreased activation in left lateral prefrontal and right parietal neural networks from the patient group and confirmed the earlier findings on the impaired working memory of patients with schizophrenia using fMRI investigation. The regions implicated in our study suggest an abnormal functioning of the fronto-parietal cortical areas that are critical to the information processing stream, which might be correspondent to common pathophysiology rather than a common etiology in schizophrenia.

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Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on F-statistics

  • Song, Hae-Hiang;Hu, Hae-Jin;Seok, In-Hae;Chung, Yeun-Jun
    • Genomics & Informatics
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    • 제10권2호
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    • pp.81-87
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    • 2012
  • Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far discovered. Although the examination of relatively large numbers of specific ethnic groups has recently started in regard to inter-ethnic group differences in CNVs, identifying and understanding particular instances of natural selection have not been performed. The traditional $F_{ST}$ measure, obtained from differences in allele frequencies between populations, has been used to identify CNVs loci subject to geographically varying selection. Here, we review advances and the application of multinomial-Dirichlet likelihood methods of inference for identifying genome regions that have been subject to natural selection with the $F_{ST}$ estimates. The contents of presentation are not new; however, this review clarifies how the application of the methods to CNV data, which remains largely unexplored, is possible. A hierarchical Bayesian method, which is implemented via Markov Chain Monte Carlo, estimates locus-specific $F_{ST}$ and can identify outlying CNVs loci with large values of FST. By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.