• 대한핵의학회지
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• 제25권1호
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• pp.95-100
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• 1991

Computerized scintigraphv using $^{99m}Tc-DTPA$ was performed to 37 isolated rabbit kidneys after preservation for 48 hours in perfusates differing in their compositions, i. e., Group 1 (N 9) in Collins' solution, Group 2 (N 10) in Collins' plus trifluoperazine, Group 3 (N 9) in Collins' plus urokinase and Group 4 (N 9) in Collins pius urokinase plus verapamil. Satisfactory images, and statistically analyzable quantitative indices such as perfusion score, filtration rate and cortical uptake ratio (CUR) were obtained by the evaluations of first-pass perfusion, equilibration slopes and postequilibration images. Significant improvements in CUR were observed by adding trifluoperazine (Group 2) and urokinase (group 3) as compared to Collins' only group (Group 1), p<0.05 for each, and all of the three indices (perfusion score, filtration rate and CUR) were also significantly (p=0.0092 p<0.05 and p<0.05) improved by adding urokinase plus verapamil (Group 4). We concluded that the computerized scintigraphy with Tc-99m DTPA provide valuable quantitative indices for evaluation of preserved kidney funcitions and suggest its possible clinical applicability in cadaver kidney transplantation considering the safety and easiness of the prodedure.

• Asian-Australasian Journal of Animal Sciences
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• 제11권5호
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• pp.580-585
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• 1998

The study was conducted to determine if variation in protein yield can be explained by expressions of early lactation somatic cell score (SCS) and if prediction can be improved by including SCS among the predictors. A data set was prepared (n = 663,438) from Wisconsin Dairy Improvement Association (USA) records for protein yield with sample days near 20. Stepwise regression was used requiring F statistic (p < .01) for any variable to stay in the model. Separate analyses were run for 12 combinations of four seasons and first three parities. Selection of SCS variables was not consistent across seasons or lactations. Coefficients of detennination ($R^2$) ranged from 51 to 61% with higher values for earlier lactations. Including any expression of SCS in the prediction equations improved $R^2$ by < 1 %. SCS was associated with milk yield on the sample day, but the association was not strong enough to improve the prediction of future yield when other expressions of milk yield were in the model.

• Journal of Nutrition and Health
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• 제37권5호
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• pp.373-384
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• 2004

The objectives of this study were to identify dietary patterns of Korean middle school students and to investigate the characteristics of dietary intake of subjects with different dietary pattern. Three-day diet records were obtained from 163 male and 155 female 7th graders in Seoul, Korea. Food items from the diet records were aggregated into 22 food groups before subjected to factor analysis. Four dietary patterns emerged from factor analysis with different factor score. Cluster analysis using factor score classified subjects into three groups named 'Traditional' (n = 42), 'Westernized' (n = 135), and 'Intermediate' (n = 145). Major nutrient intake and dietary quality assessed by NAR (Nutrients Adequacy Ratio), MAR (Mean Adequacy Ratio), DDS (Dietary Diversity Score), and DVS (Dietary Variety Score) of the three groups were compared. Mean energy intakes of three groups were 1783, 1916, 1578 kcal in Traditional, Westernized, and Intermediate diet group respectively. Differences in nutrient intake of the groups were significant in all nutrients except vitamin B$_1$. Percent energy from fat was significantly higher in Westernized and Intermediate diet group, and cholesterol intake of Westernized diet group was higher than 300mg. NARs of most nutrients were higher in Traditional and Westernized than Intermediate diet group except vitamin E. Traditional and Westernized diet groups had the highest MAR of fourteen nutrients. DDS was the highest in Westernized and DVS was the highest in Traditional and Westernized diet group. Traditional diet groups had 22％ of energy consumption from breakfast, significantly higher than other diet groups. In conclusion, these results suggest that Korean teenagers with Traditional diet pattern have lower diet in ％ energy from fat, diversity of food and regularity of meals. Future studies need to focus on the relationship between dietary patterns and health status of Korean teenagers.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.675-685
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• 2018

Purpose: This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR. Methods: A total of 45 patients aged ${\geq}60years$ with HDM-induced AR who had ${\geq}3$ A/H ratio on skin prick test and/or ${\geq}0.35IU/L$ to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15). Rhinoconjunctivitis total symptom score (RTSS), rhinoscopy score, Korean rhinoconjunctivitis quality of life questionnaire, rhinitis control assessment test, asthma control test scores, and adverse reactions, were assessed at the first visit (V1) and after 1 year of treatment (V5); for immunological evaluation, serum levels of HDM-specific immunoglobulin A/IgE/IgG1/IgG4 antibodies and basophil response to HDMs were compared between V1 and V5 in both groups. Results: There were no significant differences in demographics, RTSS, skin reactivity to HDMs, or serum total/specific IgE levels to HDMs (P > 0.05, respectively) between the 2 groups. Nasal symptom score and RTSS decreased significantly at year 1 in the 2 groups (P < 0.05). There were no significant differences in percent decrease in nasal symptom score and RTSS at year 1 between the 2 groups (P > 0.05); however, rhinoscopic nasal symptom score decreased significantly in the SLIT-treated group (P < 0.05). Immunological studies showed that serum specific IgA levels (not specific IgE/IgG) and CD203c expression on basophils decreased significantly at V5 in the SLIT-treated group (P = 0.011 and P = 0.001, respectively), not in the control group. The control group required more medications compared to the treatment group, but there were no differences in adverse reactions. Conclusions: It is suggested that HDM-SLIT for 1 year could induce symptom improvement and may induce immunomodulation in elderly rhinitis patients.

• 한국축산시설환경학회지
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• 제12권3호
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• pp.107-114
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• 2006

본 연구는 젖소에 있어서 세족기 및 신개발 세족액의 적용효과를 구명하기 위하여 2004년 축산연구소 및 전문경영체농장 2개소에서 사육중인 홀스타인 착유우를 대상으로 신개박 세족기 및 세족액을 적용하여 다음과 같은 결과를 얻었다. 1. 유산동의 MIC와 MBC는 E. coli 및 Bacillus에 대해서 공히 0.31%로 나타났다. 신개발 세족액의 경우 E. coli에 대해서는 MBC가 5%로 나타났고 Bacillus에 대해서는 2.50%로 나타났다. 2. E. coli의 경우 5% 및 16% 농도에서 각각 95.69% 및 95.87%의 감소율을 나타내었고 Bacillus의 경우 5% 및 16% 농도에서 각각 99.5% 및 99.89%의 감소율을 나타내었다. 3. 30일동안 사용하였을 때 보행자세지수(locomotion score ; LS) 2, LS3, LS4 및 LS5의 경우 100%, 43.8%, 14.3% 및 0%의 정상회복율을 나타내었고 누적하여 60일동안 사용하였을 때 LS2, LS3, LS4 및 LS5의 경우 100%, 81.3%, 71.4% 및 50.0%의 정상회복율을 나타내었다. 4. 신개발 세족액을 사용하기 전과 후의 발굽장애 발생율에 있어서 사용 전에는 18.8%의 발생율을 보였으나 사용 후에는 1.5%의 발생율을 나타내었다.

• International journal of thyroidology
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• 제11권2호
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• pp.152-159
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• 2018

Background and Objectives: Sodium-iodine symporter (NIS) is a marker for the degree of differentiation in thyroid cancer. The genetic factors or microenvironment surrounding tumors can affect transcription of NIS. In this study, we investigated the NIS mRNA expression according to mutational status and coexistent lymphocytic thyroiditis in papillary thyroid cancer (PTC). Materials and Methods: The RNA expression levels of NIS in the samples from database of The Caner Genome Atlas (TCGA; n=494) and our institute (n=125) were analyzed. Results: The PTCs with the $BRAF^{V600E}$ mutation and the coexistence of $BRAF^{V600E}$ and TERT promoter mutations showed significantly lower expression of NIS (p<0.001, respectively), and those with BRAF-like molecular subtype also had reduced expression of NIS (p<0.001). NIS expression showed a positive correlation with thyroid differentiation score (r=0.593, p<0.001) and negative correlations with expressions of genes involved in ERK signaling (r=-0.164, p<0.001) and GLUT-1 gene (r=-0.204, p<0.001). The PTCs with lymphocytic thyroiditis showed significantly higher NIS expression (p=0.013), regardless of mutational status. Conclusion: The NIS expression was reduced by the $BRAF^{V600E}$ mutation and MAPK/ERK pathway activation, but restored by the presence of lymphocytic thyroiditis.

• 농업과학연구
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• 제49권3호
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• pp.441-450
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• 2022

This study explored the effects of milk flavor (MF) supplementation on growth efficiency, nutrient absorption, fecal score, and blood profiles in weaning piglets. A total of 80 (21 days old) crossbred ([Yorkshire × Duroc] × Landrace) healthy weaned piglets with an initial body weight (BW) of 7.05 ± 1.22 kg were randomly allotted to one of two nutritive treatments with 8 repetitions and five pigs (2 female and 3 male) per pen. The experiment was divided into 2 phases (d 0 - 21, and d 21 - 42), and the dietary treatments consisted of TRT1, basal diet, TRT2 and basal diet + 1.0 g·kg^-1 MF. At days 21 - 42 and the overall period, the average daily gain (ADG) and average daily feed intake (ADFI) increased (p < 0.05) by receiving the MF added feed. However, MF inclusion did not impact (p > 0.05) the feed efficiency (G : F) throughout the entire experiment. Piglets consuming the MF supplemented diet showed that the apparent total tract digestibility of dry matter (DM), nitrogen (N) and energy (E) did not vary significantly (p > 0.05) between the treatments. All through the experiment, the fecal score and blood profile of the piglets fed the flavor diet also remained unaffected (p > 0.05). In conclusion, MF addition to the diet of the piglets increased their body weight and had no adverse effects on nutrient utilization, fecal score, and blood profile. Thus, MF addition could improve the performance outcomes of weaning piglets.

• Journal of Gastric Cancer
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• 제18권2호
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• pp.109-117
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• 2018

Purpose: This study aimed to investigate the outcomes of laparoscopic gastrectomy in very elderly patients with gastric cancer, who have outlived the average lifespan of the Korean population (men: ${\geq}77years$, women: ${\geq}84years$). Materials and Methods: Between 2004 and 2015, 836 patients with gastric cancer underwent a laparoscopic gastrectomy. They were divided into the elderly group (EldG) and non-elderly group (nEldG). Propensity score matching for covariates of sex, tumor depth, node status, and extent of resection was performed. Clinicopathologic characteristics, and surgical and survival outcomes were compared between the 2 groups. Results: The EldG had a higher American Society of Anesthesiologists (ASA) score and a higher number of comorbidities. There was no significant difference in the post-operative complications, except for pulmonary complications, which were more frequent in the EldG (5/56, 8.9%) than in the nEldG (0/56, 0%). The EldG had a shorter overall survival (OS), but cancer-specific survival was similar for both groups. Among deceased patients, 2 (25%) and 8 patients (50%) died within a year of surgery in the nEldG and EldG, respectively. Univariate and multivariate risk factor analyses for OS showed that age, ASA score, tumor, node, metastasis (TNM) stage, and occurrence of complications were significantly related to deterioration in OS. Conclusions: Laparoscopic gastrectomy can be safely performed in very elderly patients with gastric cancer who have outlived the average lifespan of the Korean population. However, impact of laparoscopic gastrectomy on improving survival is not clear, and careful patient selection is recommended.

• 대한수의학회지
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• 제61권4호
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• pp.36.1-36.8
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• 2021

The objective of this study was to evaluate the beneficial effects of the short-term application of insect-based diet in canine allergic dermatitis. Total 19 atopic dogs with concurrent cutaneous adverse food reactions were enrolled and classified into 3 groups. The treatment group (n = 7) was fed insect-based diet, the positive control group (n = 6) was fed salmon-based diet, and the negative control group (n = 6) was fed commercial or homemade diet for 12 weeks. The degree of skin lesions was evaluated based on canine atopic dermatitis extent and severity index (CADESI-4). Additionally, transepidermal water loss (TEWL) and pruritus visual analog scale were evaluated. All indices were evaluated every 4 weeks after the initial administration of hypoallergenic diets. In the treatment group, significant decrease in the CADESI-4 score was observed at 8 weeks compared to the baseline score (p = 0.031). There were significant differences in the CADESI-4 score between the groups at 8 weeks (p = 0.008), 12 weeks (p = 0.012), and TEWL at 12 weeks (p = 0.022). This preliminary result demonstrates the potential hypoallergenicity of an insect-based diet through features that diminish cutaneous lesions and skin barrier dysfunction.

• Journal of Gastric Cancer
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• 제18권2호
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• pp.189-199
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• 2018

Purpose: This study sought to examine whether near total gastrectomy (nTG) confers a longterm nutritional benefit when compared with total gastrectomy (TG) for the treatment of gastric cancer. Materials and Methods: Patients who underwent nTG or TG for gastric cancer were included (n=570). Using the 1:2 matched propensity score, 25 patients from the nTG group and 50 patients from the TG group were compared retrospectively for oncologic outcomes, including long-term survival and nutritional status. Results: The length of the proximal resection margin, number of retrieved lymph nodes and tumor nodes, metastasis stage, short-term postoperative outcomes, and long-term survival were not significantly different between the groups. The body mass index values, and serum total protein and hemoglobin levels of the patients decreased significantly until postoperative 6 months, and then recovered slightly over time (P<0.05); however, there was no difference in the levels between the groups. The prognostic nutritional index values and serum albumin levels decreased significantly until postoperative 6 months and then recovered (P<0.05); the levels decreased more in the nTG group than in the TG group (P<0.05). The mean corpuscular volumes and serum transferrin levels increased significantly until postoperative 1 year and then recovered slightly over time (P<0.05); however, there was no difference between the groups. Serum vitamin $B_{12}$, iron, and ferritin levels of the patients did not change significantly over time, and no difference existed between the groups. Conclusions: A small remnant stomach after nTG conferred no significant nutritional benefits over TG.