• 대한두경부종양학회지
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• 제39권1호
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• pp.33-36
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• 2023

Malignant lymphoma rarely occurs in the larynx and hypopharynx. Few cases of malignant lymphoma in the larynx were reported in Korea. However, malignant lymphoma in the hypopharynx had been not reported in Korea. A 68-year-old woman came to the outpatient clinic with a foreign body sensation in her throat. A round, smooth margin, bright pink-colored mass was confirmed by the laryngoscopy. The patient took neck computer tomography. A small bulging of mucosa was observed, but there was no peripheral infiltration or abnormally enlarged lymph nodes. We did excision using CO2 LASER. She was finally diagnosed with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). After diagnosis, several image studies confirmed that there was no metastatic lesion. She got only radiotherapy after that and kept a complete response state for over 2 years.

• 동의생리병리학회지
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• 제34권6호
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• pp.326-333
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• 2020

Nitrate-nitrite-nitric oxide (NO) pathway is a major alternative source of NO and is essential for NO - dependent physiological functions in body. Food supplements having nitrate/nitrite can improve metabolic syndromes including hypertension through antioxidant activity or vasodilation. The purpose of this study was to observe the effects of fermented garlic (F. garlic) having high concentration of NO2- on changes in blood flow and nitric oxide synthesis in the cerebral cortex of rodents. The generation of nitric oxide detected by a chemi-luminescence detector was higher in F. Garlic compared with NaNO2 solution under artificial gastric juice with pH 2.0. Ether F. garlic or NaNO2 diluted with artificial cerebrospinal fluid was directly applied into around the needle probe of laser Doppler flow meter that was located on epidural surface of the cortex. Direct application of F. garlic resulted in increase of cerebral blood flow detected by a laser Doppler flow meter with a dose-dependent manner. Compared with NaNO2 solution, F. garlic produced changes in cerebral blood flow at lower concentration of NO2-. Pretreatment of methylene blue, a guanylyl cyclase inhibitor prevented upregulation of cerebral blood flow by the treatment of F. garlic. In addition, the application of F. garlic with 250, 500ppm of NO2- caused significantly the production of NO in the cortical tissue but NaNO2 solution with 500ppm of NO2- did not. In summary, these results suggested that F. garlic with high content of NO2- induce increase in cerebral blood flow through nitric oxide-dependent signal pathway.

• 전기학회논문지
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• 제57권12호
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• pp.2351-2357
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• 2008

Noninvasive radial artery pulse wave has been widely used not only for the pulse wave analysis(PWA) itself but also for assessment of arterial stiffness with estimated aortic pulse wave from peripheral pulse wave. However, it has been found that the deformation of pulse shape can be caused readily by changing measuring position, indentation pressure, and so on. So, in this study, we have developed a system which can measure radial pulse wave and skin displacement simultaneously while the indentation body goes down to occlude subject's radial artery. This system can be divided into a measuring apparatus part, an indentation control hardware part, a data acquisition part and a control and computation part. And, the measuring apparatus consists of an arm-rest, a step motor, an indentation body, a laser displacement sensor(LK-G30, Keyence Co.) and pulse wave sensor. Under load-free condition and radial artery loaded condition, the evaluation of developed system has been performed. From these results, we can conclude: 1) The developed system can control the indentation body quantitatively and the adopted laser displacement sensor shows linear output characteristic even with skin as a reflector. 2) This system can measure the pulse wave and the displacement of indentation body, that is, skin displacement simultaneously at each specific level of indentation body. 3) This system can provide the number of motor steps used to get down the indentation body, the measured skin displacement, the calculated indentation pressure, the calculated pulse pressure and the pulse waveform as well as the information generated by combining these with each others. 4) This system can reveal the relationship between the morphological changes of pulse wave and the estimated displacement of radial artery wall by indentation. Consequently, the developed system can furnish more abundant information on radial artery than previous diagnosis systems based on tonometric measurement. In further study, we expect to setup the standard measuring process and to concrete the algorithm for the estimation of radial artery's diameter and of displacement of radial artery's wall. Furthermore, with well designed clinical studies, we hope to turn out the usefulness of developed system in the field of cardiovascular system evaluation.

• 한국농림기상학회지
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• 제17권1호
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• pp.15-24
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• 2015

$CH_4$는 $CO_2$ 및 $N_2O$와 더불어 중요한 온실가스로서 지속적이고도 체계적인 감시가 요구된다. 에디 공분산 기술 기반의 $CO_2$ 플럭스의 관측은 이미 세계적으로 관측망이 구축되어 관측부터 자료처리에 이르기까지 모든 과정이 표준화되어 있을 뿐 아니라 체계적으로 잘 문서화되어 있다. 그러나 미량 기체인 $CH_4$의 경우, 레이저 기반의 고속반응 분광계를 필요로 할 뿐 아니라, 이에 수반되는 플럭스 자료의 처리 과정이 표준화되어 있지 않다. 본 연구 노트에서는 최근에 상용화된 개회로 파장 변조 분광계를 사용하여 에디 공분산 방법으로 논에서 관측한 $CH_4$ 플럭스 결과를 보고하였다. 모내기 전과 직후의 각 5일간 연속 관측한 자료를 KoFlux 프로토콜에 따라 상용화된 $EddyPro^{TM}$ 프로그램을 사용하여 자료를 처리하였다. 이 후처리 과정에서 세 가지 주요 보정, (1) 주파수 반응 보정, (2) 공기 밀도 보정, (3) 분광 보정의 효과를 정량화 하였다. 보정 효과는 밤과 낮에 따라 차이를 보였고, 메탄플럭스가 작을수록 보정 효과가 컸다. 전반적으로 보정 후에 메탄 플럭스는 평균 20-25% 정도 증가하였다. 국가농림기상센터(www.ncam.kr)에서는 분광 보정과 빈 자료 메우기를 포함한 $CH_4$플럭스 자료 처리가 포함된 업데이트된 KoFlux 프로그램을 일반 사용자에게 제공할 예정이다.

• Journal of Computational Design and Engineering
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• 제1권3호
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• pp.202-212
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• 2014

To survive in the current shipbuilding industry, it is of vital importance for shipyards to have the ship components' accuracy evaluated efficiently during most of the manufacturing steps. Evaluating components' accuracy by comparing each component's point cloud data scanned by laser scanners and the ship's design data formatted in CAD cannot be processed efficiently when (1) extract components from point cloud data include irregular obstacles endogenously, or when (2) registration of the two data sets have no clear direction setting. This paper presents reformative point cloud data processing methods to solve these problems. K-d tree construction of the point cloud data fastens a neighbor searching of each point. Region growing method performed on the neighbor points of the seed point extracts the continuous part of the component, while curved surface fitting and B-spline curved line fitting at the edge of the continuous part recognize the neighbor domains of the same component divided by obstacles' shadows. The ICP (Iterative Closest Point) algorithm conducts a registration of the two sets of data after the proper registration's direction is decided by principal component analysis. By experiments conducted at the shipyard, 200 curved shell plates are extracted from the scanned point cloud data, and registrations are conducted between them and the designed CAD data using the proposed methods for an accuracy evaluation. Results show that the methods proposed in this paper support the accuracy evaluation targeted point cloud data processing efficiently in practice.

• JSTS:Journal of Semiconductor Technology and Science
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• 제1권4호
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• pp.239-247
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• 2001

The Fluorescence-Activated Cell Sorter (FACS) is a well-established instrument used for identifying, enumerating, classifying and sorting cells by their physical and optical characteristics. For a miniaturized FACS device, a disposable plastic microchip has been developed which has a hydrodynamic focusing chamber using soft lithography. As the characteristics of the spatially confined sample stream have an effect on sample throughput, detection efficiency, and the accuracy of cell sorting, systematic fluid dynamic studies are required. Flow visualization is conducted with a laser scanning confocal microscopy (LSCM), and three-dimensional flow structure of the focused sample stream is reconstructed from 2D slices acquired at $1\mutextrm{m}$ intervals in depth. It was observed that the flow structure in the focusing chamber is skewed by unsymmetrical velocity profile arising from trapezoidal cross section of the microchannel. For a quantitative analysis of a microscopic flow structure, Confocal Micro-PIV system has been developed to evaluate the accelerated flow field in the focusing chamber. This study proposes a method which defines the depth of the measurement volume using a detection pinhole. The trajectories of red blood cells (RBCs) and their interactions with surrounding flow field in the squeezed sample stream are evaluated to find optimal shape of the focusing chamber and fluid manipulation scheme for stable cell transporting, efficient detection, and sorting

• 대한기계학회논문집B
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• 제21권1호
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• pp.153-164
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• 1997

Flame oscillation phenomena in a co-flow diffusion flame was experimentally studied with periodic fuel supply using a solenoid valve. The degree of excitation was controlled by changing the volume flux of fuel passing through the valve. Flame oscillation frequencies were measured utilizing a photodiode, a spectrum analyzer, video and high speed movies. Laser planar visualization was employed to study the correlation between the flame oscillation and the toroidal vortices. Observed are three regimes of flame oscillation, where the oscillation frequencies are for the multiples of excitation, the excitation itself and the flame natural oscillation. Both periods of natural oscillation and of excitation induced oscillation exist over one cycle of the excitation in the frequency multiplied regime. It is considered as an effect of balancing the influence of buoyancy driven vortex with that of excitation induced vortex near the excitation rate of 0.2. Flame shapes are become monotonous as increasing the excitation frequency to the range of over two fold of the natural oscillation. The flame oscillation can be modulated to the frequency of either multiples of excitation or excitation itself under certain conditions. This implies that the flame oscillation could be modulated to avoid the resonance frequency of the combustor, and shows the possibility of active control of the flame oscillation.

• 한국화재소방학회논문지
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• 제29권5호
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• pp.29-33
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• 2015

본 연구에서는 노즐의 형상변화에 따라서 방사유량, 살수분포 그리고 액적크기를 측정하였다. 이를 위해서 중심부 직경이 6.0 mm이고 반지름 방향 방사각도가 $142^{\circ}$와 $148^{\circ}$인 이중 구조의 미세 물분무 노즐(LPN142, LPN148) 형상을 제작하여 UL2167 시험규격에 의해서 살수분포와 분사거리의 관계를 정량화하였다. Hellium-Neon 레이져에 의한 광학적 분석 방법을 적용하여 방사유량 변화에 따라서 웨버 수와 액적 크기 그리고 방사각도에 관한 경험식을 구하였으며, 전달 방정식의 주요인자인 소멸 항과 액적크기의 상관관계를 분석하였다. 그 결과 이중 구조의 미세 물분무 노즐은 최소허용 유량범위가 결정된 경우 작동압력, 분사거리, 액적 직경을 예측하여 화재특성을 분석함으로써 노즐 선정이 가능할 것으로 사료된다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.268-279
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• 2003

The nano capsulation of the ceramide was a technique that capsulated ceramide III and tocopheryl linoleate at the mono-vesicle, so as to act the horny layer in skin. It was used 0.5-5.0 wt% of hydrogenated lecithin and 0.01~2.00 wt% of lysolecithin as the membrane-strengthen agents of the mono-vesicle, 5.0~10 wt% of propylene glycol and 5.0~10.0 wt% of ethyl alcohol made by high-pressure Microfluidizer. To enhance the moisturizing efficacy and treat an atopy skin, used ceramide III and tocopheryl linoleate as the active ingredients, and it was made the nano-capsule that synthetic emulsifiers were free. The optimal condition of capsulation of nano ceramide was as follows. The conditions were 3 times at 1,000bar and 60-7$0^{\circ}C$. The particle size showed 63.1$\pm$7.34 nm such as the transparence water as the results for measuring by the laser light scattering. A zeta potential value was -55.1$\pm$0.84 ㎷. The result of the clinical test, the moisturizing effect (in-vivo, n=8, p-value<0.05) was improved 21.15% compared to control, as well as it was improved 36.31 % before the treatment. Moreover, the effectiveness of atopy skin indicated positive reaction that patients were 10 volunteers.

• Journal of Ship and Ocean Technology
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• 제6권4호
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• pp.1-12
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• 2002

A control system for an automated line heating process is developed by use of object-oriented methodology. The main function of the control system is to provide real-time heating information to technicians or automated machines. The information includes heating location, torch speed, heating order, and others. The system development is achieved by following the five steps in the object-oriented procedure. First, requirements are specified and corresponding objects are determined. Then, the analysis, design, and implementation of the proposed system are sequentially carried out. The system consists of six subsystems, or modules. These are (1) the inference module with an artificial neural network algorithm, (2) the analysis module with the Finite Element Method and kinematics analysis, (3) the data access module to store and retrieve the forming information, (4) the communication module, (5) the display module, and (6) the measurement module. The system is useful, irrespective of the heating sources, i.e. flame/gas, laser, or high frequency induction heating. A newly developed automated line heating machine is connected to the proposed system. Experiments and discussions follow.