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Carbanilide 유도체의 합성 및 항균작용에 관한 연구 (Studies on the Syntheses and Antimicrobial Activity of Carbanilide Derivatives)

  • 강회양
    • 한국환경보건학회지
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    • 제7권2호
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    • pp.107-111
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    • 1981
  • Thirteen Carbanilides, P-chloro, bromo, methyl, ethyl, methoxy and ethoxy carbanilides, 4,4'-dichlorocarbahilide, and 4-bromo, methyl, ethyl, methoxy and ethoxy 4'-chlorocarbanilides have been newly synthesized by reacting P-phenetidime, P-anisidime, anilime, P-chloroanilime, P-bromoanilime, P-methoxy aniline, and P-ethoxy anilime with phenyl and P-chlorophenyl isocyanate, respectively. The compounds generally exhibited antibacterial activity against Escherichia coli, and staphylococcus aureus. The results obtained were as follows 4-chlorocarbanilide and 4,4'-clichlorocarbanilide were active against Eschrichia Coli, and Staphylococcus aureus at the concentration of 50 ug/ml. 4-methyl-4'-chloro carbanilide, and 4-ethoxy-4'-chloro carbanilide were active against Escherichia Coli at the concentration of 100ug/ml. 4-methyl-4'-chloro canbanilide were active against Staphylococcus aureus at the concentration of 50ug/ml.

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Yohimbine과 Atipamezole이 Xylazine-Ketamine 병용 마취견의 뇌파에 미치는 영향 (Effects of Yohimbine and Atipamezole in Dogs Anesthetized with Xylazine-Ketamine Combination on EEG)

  • 장환수;장광호;이만기;장인호
    • 한국임상수의학회지
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    • 제19권2호
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    • pp.174-185
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    • 2002
  • We investigated the effects of yohimbine and atipamezole in dogs anesthetized with xylazine-ketamine combination on electroencephalography (EEG) . Experiment groups were divided into three according to antagonists . Saline (1 ml) was used as an antagonist in group C, yohimbine (0.1 mg/kg) in group Y and atipamezole (50 ug/kg) in group A. Each group consisted of 5 dogs. Glycopyrrolate was injected 15 minutes prior to xylazine injection. Xylazine (1.1 mg/kg, IM) and ketamime (10 mg/kg, IV) were injected with the interval of 10 minutes. After 15 minutes, antagonists were administered intravenously. For EEG measurements, a recording electrode was positioned at Cz, which was applied to International 10-20 system. Heart rates, body temperature, respiratory rates, arterial blood pressure, $PaO_2$$PaCO_2$$PaCO_2$ at S4 in group Y was significantly decreased(p<0.05). Changes of electrolytes were not significant, except value of $Cl^-$ at S3 in group A. Mean head-up time (the time dogs showing head-up movement after antagonist injection, minutes) was $38.23^{\circ}$ae6.46 in group C, 2.54 $\pm$ 0.93 in group Y and 2.12$\pm$ 1.32 in group A. Mean sternal recumbent time (the time dogs showing sternal recumbency after antagonist injection, minutes) was 45.93$\pm$ 10.27 in group C, 11.91 $\pm$ 7.19 in group Y and 9.88$\pm$ 3.38 in group A. Mean walking time (minutes) was 53.49$\pm$ 9.21 in group C, 22.10$\pm$ 11.10 in group Y and 18.48$\pm$ 4.39 in group A. In group Y all dogs showed excitation and muscle rigidity in emergence. In group A, two dogs were also showed excitation and muscle rigidity, but were weaker than those of group Y.

하악골 측방변위가 가토의 하악두에 미치는 영향에 관한 실험적 연구 (AN EXPERIMENTAL STUDY ON THE MANDIBULAR CONDYLAR GROWTH FOLLOWING LATERAL DISPLACEMENT IN RABBIT)

  • 신동용;서정훈
    • 대한치과교정학회지
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    • 제22권2호
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    • pp.427-447
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    • 1992
  • The purpose of this study was to evaluate the effect of the lateral displacement on the mandibular condylar growth in the rabbit. The experimental animals were twenty White NewZealand rabbits of 4-week old. Ten of them was used as control group, and experimental animal was composed of remaining ten. Laterodeviation appliance was made of cast base metal and appliance was cemented with resin in permanent fashion. Experimental group were sacrificed at 1, 2, 4, 6, 8 weeks form beginning of the experiment. Both of temporomandibular joint were prepared for histologic study. The conclusions are: 1. In control group, there was slight increase of proliferative zone and hypertrophic zone at 2-week control animal and slight reduction at 4-week. 6-week and 8-week control animal were similiar to 1-week control animal. 2. In right mandibular condyle of experimental group, 2-week experimental animal showed marked increase of proliferative zone and hypertrophic zone at posterior surface of condylar head. In 8-week experimental animal marked increase at anterior surface of anticular surface is observed. 3. In left mandibular condyle of experimental group, proliferative zone and hypertrophic zone were reduced at 1-week experimental animal and slight increase at 2-week. Proliferative zone and hypertrophic zone were reduced at 4-week experimental animal and were slightly increased at 6 week. 4. After 8 weeks, right and left condyle were not different in experimental group. The condylar cartilage was stabilized 8 weeks after the experiment. No marked traumatic change was seen, but minute focal bleeding was seen at articular cavity in 1-week, 2-week and 4-week experimental animal. 6-week and 8-week experimental animal did not show bleeding tendency in articular cavity.

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무기태 질소시비가 초지의 수량과 식생구성에 미치는 영향 I. 초지의 수량과 경제적 무기태 질소시비한계 (efficiency of Mineral Nitrogen Fertilization on Yield and Botanical Composition of Grassland I. Dry matter yield and economical mineral nitrogen of grassland)

  • 조익환
    • 한국초지조사료학회지
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    • 제10권2호
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    • pp.102-109
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    • 1990
  • This experiment was carried out to study the effect of pure mineral nitrogen fertilizing on dry matter yield of grassland and the advisable mineral nitrogen amounts in long duration under practical conditions at the "Federal Institute for Agriculture in the Alps" in Austria. The application rates were 0, 30, 60,90 and 120 kg N/ha/cut, the cutting regimes 3-, 4-, 5- and 6-cuts/year. In order to explain the nitrogen-profitability were determined that 1 kg pure mineral nitrogen have to produce 8 - 16 kg DM/kg N in dependence on cutting regimes and requiring of nitrogen efficiencies. The results were as follows: 1. With only PK-fertilizaing average dry matter yields from 4.0 to 7.6 tons per ha and year were obtained. 2. Within all applied cutting regimes 60 kg min. Nlhalgrowth have proved to be the most efficient application rate witn 13 - 24 kg DM/kg N in dependent of cutting regimes. Comapred with only PK-treatment the DM yields increased by 3.9 - 4.7 t/ ha nad year. 3. By the sigmaformed process of Input-Output curve the highest marginal yield (the "most efficient" Ndressing rate) per ha and year was calculated: 152 kg N at 3-cut regimes, 204 kg N at 4-cut regimes, 220 kg N at 5-cut regimes and 240 kg N/ha/year at 6-cut regimes. 4. With required efficiencies of 16 and 12 kg DM/kg N 240 - 300 kg N per ha and year respectively would have to be applied at 3-cut regimes; with required efficiencies of 12 and 10 kg DM/kg N at 4-cut regimes the appropriate figures ranged from 320 to 420 kg N/ha and year, at 5- and 6-cut regimes and efficiencies of 10 and 8 kg DM/kg N results of 360 - 460 kg N and 380 - 500 kg N respectively were obtained. 5. At the relatively dry location Piber the highest dressing rates were needed in order to obtain the efficiencies from 8 to 16 kg DM/kg N, about 30 - 60 kg N/ha/year more than at the relatively moist location Admont.ist location Admont.

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이장재의 세포독성에 관한 실험적 연구 (AN EXPERIMENTAL STUDY ON THE CYTOTOXICITY OF CAVITY LINERS)

  • 김정혜;김영해
    • Restorative Dentistry and Endodontics
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    • 제15권2호
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    • pp.77-92
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    • 1990
  • The purpose of this study was to evaluate the cytotoxic effects of 6 cavity liners in vitro. Human fibroblasts were cultured in ${\alpha}$-MEM and each liner was manually mixed and filled in glass ring cylinder ($8{\times}8mm$ in diameter, in height). The cylinders filled with the liners were placed in the center of the dish (35mm in diameter) containing 3ml of ${\alpha}$-MEM. Millipore filters (pore size $0.22{\mu}m$) to simulate dentin barrier were also placed between the bottom of cylinder and the dish. Then the culture dishes were stored in 5% $CO_2$ containing incubator for 5 and 10 days at the temperature of $36.6^{\circ}C$. The results of the experiments were analyzed by counting the cells in the period of 5 and 10 days respectively, and were assessed by calculating the cell multiplication rate and the relative growth rate. The experiemntal groups and the control group were compared statistically. The results of the study were summarized as follows: 1. The cell number of Zinc oxide-eugenol was $(4.13{\pm}1.31){\times}10^4$ cells/ml at 5 days and $(4.32{\pm}1.61){\times}10^4$ cells/ml at 10 days. 2. The cell number of Cavitec was ($8.35{\pm}2.87{\times}10^4$ cells/ml and $(10.08{\pm}5.10){\times}10^4$ cells/ml at 5 and 10 days respectively. 3. The cell number of Dycal was $(13.56{\pm}3.89){\times}10^4$ cells/ml at 5 days and $(34.75{\pm}8.85){\times}10^4$ cells/ml at 10 days. 4. The cell number of life was $(11.46{\pm}3.32){\times}10^4$ cells/ml and $(21.92{\pm}6.18){\times}10^4$ cells/ml at 5 and 10 days. 5. The cell number of Base cement was $(13.73{\pm}3.73){\times}10^4$ cells/ml and $(36.68{\pm}5.20){\times}10^4$ cells/ml at 5 and 10 days. 6. The cell number of Dentin cement was $(13.58{\pm}3.90){\times}10$ cells/ml and $(66.95{\pm}24.09){\times}10$ cells/ml at 5 and 10 days. 7. The cell multiplication rate of zinc oxide-eugenol cements was significantly less than that of the calcium hydroxide and glass ionomer cement. (P < 0.05)

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발효 온도의 변화에 따른 열무 물김치 중 비타민 C의 함량 변화 (The Changes of Vitamin C Content in Yulmoo Mulkimchi According to the Shift of Fermentation Temperature)

  • 최성유;한영숙
    • 한국식품조리과학회지
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    • 제13권3호
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    • pp.364-368
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    • 1997
  • 김치의 비타민 C 함량은 초기값에 비해 증가되었다가 감소하는 것으로 알려져 있어 이에 물김치를 담가 발효, 숙성온도를 달리하여 그 국물에 대하여 pH, 산도, 비타민 C 함량, 총균수, 젖산균수의 변화를 살펴본 결과는 다음과 같다. 3$0^{\circ}C$에서 1일간 숙성시킨 후 비타민 C 함량은 최고에 달해 20 mg% 정도를 나타냈으며, 이때의 pH는 4.5 내외, 산도는 0.2 lactic acid %였고, 미생물균수는 최고 $10^{8}$ CFU/$m\ell$를 나타냈으며 대부분을 젖산균이 차지했다. 이 결과는 그후 온도를 낮춰 15$^{\circ}C$, 4$^{\circ}C$에서 9일간 숙성을 시켜도 차이가 나지않았다. 15$^{\circ}C$에서 발효, 숙성시킨 김치는 최고의 비타민 C 함량인 15 mg%의 비타민 C 함량을 나타낼 때까지 4~5일이 소요되었으며, 이때의 pH는 4.0, 산도는 0.15 lactic acid %였다. 한편 15$^{\circ}C$에서 1일간 발효 후 4$^{\circ}C$에서 숙성시킨 경우에도 이 수준까지 떨어지지 않았다. 4$^{\circ}C$ 발효, 숙성의 경우에는 pH와 산도가 저장 10일 동안 초기값과 크게 달라지지 않았으며, 비타민 C가 증가하지 않아 약 10 mg%에 머물렀다.

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Synthesis and Properties of Poly[oxy(arylene)oxy(tetramethyldisilylene)]s via Melt Copolymerization Reaction

  • Jung, Eun Ae;Park, Young Tae
    • Bulletin of the Korean Chemical Society
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    • 제34권6호
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    • pp.1637-1642
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    • 2013
  • We carried out the melt copolymerization reactions of 1,2-bis(diethylamino)tetramethyldisilane with several aryldiols such as, 4,4'-biphenol, 4,4'-isopropylidenediphenol, 9H-fluoren-9,9-dimethanol, and 4,4'-(9-fluorenylidene) bis(2-phenoxyethanol) to afford poly[oxy(arylene)oxy(tetramethyldisilylene)]s containing fluorescent aromatic chromophore groups in the polymer main chain: poly[oxy(4,4'-biphenylene)oxy(tetramethyldisilylene)], poly[oxy{(4,4'-isopropylidene) diphenylene}oxy(tetramethyldisilylene)], poly[oxy(9H-fluorene-9,9-dimethylene) oxy(tetramethyldisilylene)], and poly[oxy{4,4'-(9-fluorenylidene)bis(2-phenoxyethylene)}oxy(tetramethyldisilnylene)]. These prepared materials are soluble in common organic solvents such as $CHCl_3$ and THF. The obtained polymers were characterized by several spectroscopic methods such as $^1H$, $^{13}C$, and $^{29}Si$ NMR. Further, FTIR spectra of all the polymers exhibited characteristic Si-O stretching frequencies at 1014-1087 $cm^{-1}$. These polymeric materials in THF showed strong maximum absorption peaks at 268-281 nm, strong maximum excitation peaks at 263-291 nm, and strong maximum fluorescence emission bands at 314-362 nm due to the presence of tetramethyldisilylene and several arylene chromophores in the polymer main chain. TGA thermograms indicated that most of the polymers were stable up to $200^{\circ}C$ with a weight loss of 3-16% in nitrogen.

간흡충 세르카리아의 Chaetotaxy에 관한 연구 (Cercarial Chaetotaxy of Clonoychis sinensis)

  • 민득영;김재진
    • Parasites, Hosts and Diseases
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    • 제26권2호
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    • pp.113-116
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    • 1988
  • 간흡충 세르카리아의 감각유두 분포양상 즉 chaetotaxy를 관찰하였다. 이 세르카리아의 chaetotaxy는 두부(cephalic region)에서 제1열에 5∼6 Ci 1, 4∼5 Ci 2, 5∼6 Ci 3, 제2열에 4 Cii 1, 2 Cii 2, 4 Cii 3, 5∼6 Cii 4, 제3열에 3∼4 Ciii 1, 2∼3 Ciii 2, 및 제 4열에 2 Civ 1, 2∼3 Civ 2, 2∼3 Civ 3의 분포를 보였으며, 몸통 부위 (body region)의 각측(V) 및 때측(D)에서 2 AiV, 1 AiD, 2 AiiV, 1 AiiB,2 kiiiv,2 AiiiD, 1 AivV, 1 AivD, 1 PiiD, 1 PiiiD, 그리고 꼬리 부위(caudal region)에서 2-2-2-2의 분포양상을 보였다. 이 결과를Opisthorchis chabaudi 및 Metagonimus yokugawai에서 보고된 chaetotaxy와 비교하였다.

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초고속 광 가입자 접속장치용 송신장치 설계 (The Transmit System for Connection System of Super High Speed Optical Fiber Subscriber)

  • 송홍종
    • 정보통신설비학회논문지
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    • 제10권1호
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    • pp.14-26
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    • 2011
  • 광 가입자용 송신 장치는 가입자 접속부의 ATM(Asynchronous Transfer Mode) 계층으로부터 ATM 셀을 비동기적인 방법으로 FIFO(First In, First Out)를 통해 수신하여 Idle/Unasigned 셀의 삽입, 셀에 대한 HEC(Header Error Correction) 계산, 그리고 셀 페이로드에 대한 스크램블링을 통해 VC4 신호 페이로드에 사상한다. 이때 VC4 POH(Path Over Head)상의 H4 바이트에 의해 셀의 시작점을 지시하고 동시에 POH 오버헤드에 대한 생성, 삽입을 통해 VC4 신호를 형성한다. 이 신호는 AU4 포인터 생성부에서 VC4의 시작점 J1을 생성하여 AUG버스를 통해 STM-1 신호 생성 부에서 프레임 형태로 출력된 후 155Mbps 속도로 광 신호로 변환되어 송신된다.

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서울 도심지역과 교외지역에서외 우수 및 에어로졸 성분의 비교 (A Chemical Components of Rain Water and Aerosol in Seoul and Suburban Area)

  • 신찬기;한의정;한진석;강인구
    • 환경위생공학
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    • 제8권2호
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    • pp.155-168
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    • 1993
  • The chemical components of rain water and aerosol in Bulkwang of Seoul and Yang-Paying of Kyunggi-do were compared in order to investigate that pollutants at urban area influences rain water and aerosol component. The following is the result of this study. 1) The pH of rain water was shown 4.82 at urban area and 5.69 at suburban area. 2) The mean concentration of $SO_4^{2-}$ within rain water at suburban was nearly the same at urban area but the mean concentration of $Na^{+},Ca^{2+},Mg^{2+}$ and $NH_4^{2+}$ at suburban area was higher than the corresponding levels at urban area. 3) The ion component of aerosol at suburban was shown 68% of that at urban area. This study proved that the concentration of rain water and aerosol component was under the influence of movement of air current.

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