• 생약학회지
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• 제36권1호통권140호
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• pp.44-49
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• 2005

The protective effects of the DWP-04 [DDB : selenium yeast: glutathione {31.1 : 6.8 : 62.1 (%, w/w)} against hepatotoxicity by carbon tetrachloride $(CCl_4)$ were studied in rats. The rats were intraperitoneally injected with $CCl_4$ (50% in com oil) at initial dose of 1 ml/kg followed by 0.5 ml/kg 3 times during 1 week. The DWP-04 (50, 100 or 200 mg/kg) or its vehicle was administered everyday before the start of $CCl_4$ injection for two weeks. $CCl_4$ induced hepatocelluar degeneration and necrosis, which led to a great increase in serum aminotransferase, alkaline phosphatase activity and serum lipid levels. It was found by biochemical analysis that $CCl_4$ treatment remarkably increased thiobarbituric acid reactive substances and physphatidylcholine hydroperoxide in hepatic tissues and induced antioxidant enzymes such as catalase and superoxide dismutase (SOD). Liver and serum lipids were significantly lower in rats fed on DWP-04 than in rats induced by $CCl_4$ only-treatment. These results suggested that the DWP-04 could be a promising candidate for the protection of liver injury based on the preventive effects against lipid peroxidation and serum biochemical parameters.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2000년도 제17차 정기총회 및 학술발표
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• pp.81-84
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• 2000

Effects of different photoperiod regimens on the cellular and humoral immunity in broiler chickens were studied(Exp 1). Total one hundred ninety two one-day-old commercial broiler chicks(Cobb$\times$Cobb) were raised between constant lighting(CL) and intermittent lighting (1h light: 3h darkness(IL; 1l; 3D) Body weight, feed intake and feed conversion were measured for seven week. Peripheral blood and splenic lymphocyte activities were tested at 3 and 5 wk of age by performing a mitogen cellproliferation assay with a polyclonal T-cell mitogen, concanavalin A (Con A), and B-cell mitogen, lipopolysaccharide (LPS). To investigate the effect of photoperiod on the humoral immunity, chicks were immunized with sheep red blood cell(SRBC) and iinactivated Newcastle disease virus(NDV) vaccine. Total immunoglobulin G(IgG) concentration was also determined. Diurnal change of melatonin was tested in sera. In experiment 2, 0.1ml melatonin were subcutaneously injected from three to five weeks old if immunomodulation effect of lighting regimen was due to the melatonin or not. Injections of melatonin were made at 0700h and the dosage was 10ng (M2), 100ng(M3), 1$\mu\textrm{g}$(M4) per bird daily, respectively. control were quivalent injections of vehicle(M1). Lymphocyte activities were tested and humoral immunities were examined at 5 weeks of age. Blood melatonin concentration was determined at 0h, 1, h, 2h, and 3h posterior to injection at five weeks old. It was higher in CL chicks than IL chickens during the subsequent period of 3 to 5 wk of age. However, weight gain of chicks raised IL were significantly higher at 6 wk of age than CL(P<0.05). Antibody response to NDV was not affected by both photoperiod regimens and melatonin injection, whereas anti-SRMB titer and IgG concentration were enhanced. Lymphocyte activity of chickens raised under IL was sighificantly higher than those of chickens raised under CL. Melatonin injection also increased lymphocyte activity. When peripheral blood lymphocytes were used, proliferation response to LPS and Con A were significantly increased in M2 and respectively. The results of this experiments suggest that IL improved host immune response and melatonin have immunomodulatory roles.

• 대한의생명과학회지
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• 제24권3호
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• pp.239-244
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• 2018

Recently, many researches regarding the natural products which alternate with chemical products have been done. Among them, boswellia is well known for effect on anti-oxidative effect and inflammation. The aim was the effect boswellia of formalin- induced orofacial and temporomandibular joint (TMJ) pain on experimental animals was investigated. Experiments were carried out using subcutaneous (SC) pain model and TMJ pain model that were induced by the injection of 5% formalin into the right vibrissa pad (SC, $50{\mu}L$) or TMJ ($30{\mu}L$) of rats, respectively. In both models, formalin (5%), formalin after distilled water (vehicle), formalin after boswellia extract (p.o., concentrations of 15, 30 mg/kg) (n=6). The number of scratching on the injected region was scored during the 9 successive periods of 5 min intervals following injection of formalin. Oral administration of boswellia (15, 30 mg / kg) reduced formalin-induced SC orofacial pain behavioral responses. SC orofacial pain behavioral responses was significantly reduced at 20~35 min. In the experimental group injected into temporomandibular joints, the pain response was significantly reduced by $276.2{\pm}8.20$ and $78.3{\pm}4.7$ after oral administration of boswellia (15, 30 mg / kg) at $398.3{\pm}24.8$ times. As a result of the passage of time, the oral administration of boswellia showed a significant effect of reducing the temporomandibular joint pain 30 minutes after the injection of formalin. This study confirmed that oral administration of boswellia modulated the pain behavior in both models. In conclusion, boswellia extract may be a potential therapeutic treatment for orofacial pain.

• 자원환경지질
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• 제32권6호
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• pp.633-644
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• 1999

Gully pot is a part of urban darainage system to butter the runoff water fluxes from road to rivers and to minimize environmental pollution by prevending over the surrounding area. A series of studies have been carried out concerning the physicochemical characteristics of the sewage sludge sediments sttling down in such a gully pot in order to over to evaluate the contamination for heavy metals such as pb, Zn, Cu and Cd. The roadside soil and sewage sludge samples from gully pots were characterized by XRD analyses and sequential extraction : Zn 2595.7$\mu$g/g; Cd9.8$\mu$/g; Cu602.5$\mu$g/g; Pb260.0$\mu$g/g),because of a long-term accumulation of vehicle- and industrial-related pollutants. Mean Zn concentration in Yeouido (3873$\mu$g/g) and Junggu(3262$\mu$g/g)areas are 4-5 times higher than those in Dobonggu area, suggesting that Zn may be derived from automobile traffic (including the rubber of automobile tires). The mean concentrations of Cu and Cr are very significantly high in Junggu and Gurogu areas, possibly due to the industrial activities in these areas. The low Pb levels throughtotut the whole study areas in Seoul can be accounted for the use of unleaded gasoline since 1987. Sequential extraction experiments illustrate that a major part of Zn is bound to FII and FIII, representing about 88% of the total Zn concentration. Fraction IV, related to orgnic matter, is mostly significant for Cu accounting for 60% of the total Cu, and FII is next in importance. The main carriers of Pb are the fractions III, II and FIV, and in that order. The behavior of Cd is quite different from other elements (Zn, Cu, Pb), and most of the Cd is associated with FV. Changes in the physicochemical environments (such as acidification) may result in severe environmental pollution of surface water and rivers with respect to heavy metals (especially Zn and Cu).

• 한국재난정보학회 논문집
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• 제20권2호
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• pp.257-269
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• 2024

Purpose: The purpose of this study is to explain the pivotal role of the travel forecasting process in urban transportation planning. This study emphasizes the use of travel forecasting models to anticipate future traffic. Method: This study examines the methodology used in urban travel demand modeling within transportation planning, specifically focusing on the Urban Transportation Modeling System (UTMS). UTMS is designed to predict various aspects of urban transportation, including quantities, temporal patterns, origin-destination pairs, modal preferences, and optimal routes in metropolitan areas. By analyzing UTMS and its operational framework, this research aims to enhance an understanding of contemporary urban travel demand modeling practices and their implications for transportation planning and urban mobility management. Result: The result of this study provides a nuanced understanding of travel dynamics, emphasizing the influence of variables such as average income, household size, and vehicle ownership on travel patterns. Furthermore, the attraction model highlights specific areas of significance, elucidating the role of retail locations, non-retail areas, and other locales in shaping the observed dynamics of transportation. Conclusion: The study methodically addressed urban travel dynamics in a four-ward area, employing a comprehensive modeling approach involving trip generation, attraction, distribution, modal split, and assignment. The findings, such as the prevalence of motorbikes as the primary mode of transportation and the impact of adjusted traffic patterns on reduced travel times, offer valuable insights for urban planners and policymakers in optimizing transportation networks. These insights can inform strategic decisions to enhance efficiency and sustainability in urban mobility planning.

• 한국항해항만학회지
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• 제26권3호
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• pp.323-328
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• 2002

강판벽체와 뒷채움 지반의 상호작용에 의해 외력을 지지하는 지중강판구조물은 도로 제방의 하부 통·수로 구조물로 널리 사용되고 있다. 해안도로로 사용되는 성토체 내에 통로용 횡단구조물로 설치한 직경 6.25m의 원형단면 지중강판구조물에 대하여 상부 도로의 차량 통행에 의한 활하중 작용시 강판 벽체의 축력과 모멘트 변화를 평가하고, 토목섬유에 의한 강판구조물 상부 지반의 보강효과를 검증하였다. 이를 위하여 실제 구조물을 대상으로 정적 및 동적 차량재하시험을 실시하고, 구조물 내에 발생하는 축력과 모멘트, 그리고 구조물에 작용하는 토압을 계측하였으며 그 결과를 각각 분석하였다. 또한 지오그리드를 이용한 토피부 보강 효과에 대해서도 검증하였다. 차량하중 작용시 강판 부재의 축력은 주로 상부 아치부에서 증가하였으며, 그 최대값은 구조물 정점부 또는 도관 어깨부에서 발생하였다. 모멘트도 상부 아치부를 중심으로 증가하는 형태를 보였으나, 그 크기는 무시할 수 있을 만큼 작았다. 정적차량하중이 가해질 때 토피부에 지오그리드를 포설한 단면에서 계측된 최대축력 증가량은 지오그리드가 설치되지 않은 단면에서 계측된 값의 85∼92%를 나타내어 사하중에 대한 효과 외에 추가적인 축력감소 효과를 확인할 수 있었으나 차량주행시에는 차량하중에 대한 추가적인 보강 효과는 없어짐을 관찰하였다. 동적재하시험을 통해 산정한 충격계수 (DLA)는 토피두께가 0.9m에서 1.5m까지 증가함에 따라 반비례하여 감소하였는데, 그 크기는 CHBDC 방법으로 예측한 값보다 1.2-1.4배 정도 크게 나타났다.

• 한국산학기술학회논문지
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• 제21권6호
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• pp.296-301
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• 2020

국내 신호등은 2색등, 3색등, 4색등의 신호체계를 적용하고 있다. 2색등은 적색•녹색 등화로 주로 횡단보도에서 사용되며 3색등은 적색•황색•녹색(녹색화살표)등화로 T자형 교차로, 4색등화 표시는 적색•황색•녹색화살표•녹색으로 일반적인 교차로에서 사용되고 있다. 교차로에 진입하는 운전자는 딜레마 존 영역에서 교차로 진입 또는 정지선에 정지 판단을 해야 한다. 교차로 진입 전 딜레마 존에서 운전자는 교차로 폭, 차량속도, 인지반응시간, 기준 황색신호 시간에 따라 교차로 통과 또는 정지선에 정지, 과속차량, 꼬리물기, 끼어들기, 신호위반 차량 등 많은 정보를 수집 판단하고 있다. 본 논문은 교차로 3,4색 신호등의 기준 황색신호 시간과 교차로 통과 속도를 50km/h, 60km/h하향 조정에 따른 딜레마 존 영역 길이 변화가 황색신호 시간에 영향을 줄 수 있음을 제시한다. 이러한 영향에 따른 황색신호 시간은 0.1~2.3초 증가함을 알 수 있었으며 딜레마 존 영역도 1.22~26[m] 증가함을 알 수 있었다. 교차로 사고 감소를 위해 딜레마 존의 운전자에게 빠른 판단할 수 있도록 직진(3색,4색) 녹색신호의 잔여시간을 표시함으로써 교차로 통행에 발생하는 교통사고를 줄이는 방안을 제시하며, 심야시간에 운영되어지는 교차로 점멸신호에 진입하는 차량에 적색(LED 손바닥)신호와 좌회전 녹색 화살표 신호를 교차 점멸함으로 안전한 진입 방안을 제시하고자 한다.

• 한국입자에어로졸학회지
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• 제8권1호
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• pp.17-28
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• 2012

Air pollution levels of gases and aerosol particles inside the Jeongneung and Hongjimun tunnels of the Naebu express way in Seoul were investigated through on-road measurement using a mobile emission laboratory (MEL) on February 8, 2011. The concentrations of $NO_x$, $CO_2$, number concentration of particles ranging 21-560 nm, and surface area of particles deposited on a human lung almost linearly increased with increasing distance from the tunnel entrance, and decreased rapidly before the tunnel exit. This trend was observed regardless of tunnel length and driving directions, which thought to be caused by semi-transverse ventilation facilities of the tunnels. The concentration increments per 1-m distance for $NO_x$, $CO_2$, deposited particle surface area, and number of particles ranging 21-560 nm were 0.61~0.80 ppb, 0.16~0.21 ppm, $0.20{\sim}0.29{\mu}m^2/cm^3$, and 117~192 particles/$cm^3$, respectively. Average pollution levels inside the two tunnels for $CO_2$, deposited particle surface area, and number of particles >5.6 nm ranged 681~748 ppm, $246{\sim}381{\mu}m^2/cm^3$, and $2.4{\sim}6.7{\times}10^5$ particles/$cm^3$, respectively. In case of $NO_x$, the maximum concentration exceeded 1 ppm. These pollution levels inside the tunnels are much higher than those at urban background sites. This result can be utilized as basic data to evaluate the effectiveness of present ventilation system for reducing the pollution level caused by vehicles inside the tunnels.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제6권11호
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• pp.537-542
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• 2017

공격적인 성향의 운전은 자동차 사고의 주요한 원인이 된다. 기존 연구에서는 공격적 성향의 운전을 검출하기 위해, 주로 청년을 대상으로 연구가 이뤄졌으며 기계학습의 순수한 Clustering 또는 Classification 기법을 통해 이뤄졌다. 그러나 노인들은 취약한 신체적 조건에 의해 젊은 운전자와는 다른 운전 강도를 가지고 있어 기존의 방식으로는 검출이 불가능 하며, 데이터를 보정하는 등의 새로운 방법이 필요하다. 그리하여, 본 연구에서는 기존의 클러스터링 기법(K-means, Expectation - maximization algorithm)에, 새롭게 제안하는 ECA(Enhanced Clustering method for Acceleration data)기법을 추가하여, 주행 차량에 위치한 스마트폰으로부터 수집된 가속도 데이터를 분석하고 공격적인 운전 형태를 검출해 낸다. ECA는 모든 피험자의 데이터에서 K-means와 EM을 통해 검출된 군집군의 데이터 중 높은 강도의 데이터를 선별하여, 특징을 스케일링한 값을 통해 모델링한다. 본 방식을 통해 기존의 연구의 순수한 클러스터링 방식과는 달리, 모든 청장년 및 노인 실험 참가자 개인들의 공격적인 운전 데이터가 검출되었으며, 클러스터링 기법간의 비교를 통해 K-means 기법이 보다 높은 검출 효율을 갖고 있음을 확인했다. 또한, K-means 방식을 검출한 공격적인 운전 데이터에서는 젊은 운전자가 노인운전자에 비해 1.29배의 높은 운전 강도를 가지고 있음을 발견했다. 이와 같이 본 연구에서 제안된 방식은 낮은 운전 강도를 갖고 있는 노인의 데이터에서 공격적인 운전을 검출 가능하게 되었으며, 특히. 제안된 방법은 노인 운전자를 위한 맞춤형 안전운전 시스템을 구축이 가능하며, 추후 다양한 연구을 통해 이상 운전 상태를 검출하고 조기 경보하는데 활용이 가능할 것이다.

• 유기물자원화
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• 제25권2호
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• pp.15-26
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• 2017

본 연구는 S시 S구의 재활용품 배출특성을 조사 및 분석을 통해 재활용품 선별장에서 재활용품 선별율을 조사하였다. 재활용품 배출특성을 조사하기 위해서 발생원, 수집운반, 선별단계별로 나누어 분석하였다. 분석결과, 재활용품의 발생량 원단위의 전체 평균은 0.121kg/일 인, 지역별 재활용품의 수거주기는 보통 주3회(월수금 혹은 화목일)로 나타났으며, 차량별 혼합재활용품의 밀도는 평균 $202.4kg/m^3$로 나타났다. 선별단계에서의 현황분석을 진행한 결과, 혼합재활용품의 반입량은 평균 1,154.6톤/달, 겉보기밀도의 평균은 $181kg/m^3$, 선별재활용품의 양은 평균 448.5kg/달, 잔재물의 밀도는 $48kg/m^3$으로 나타났다. 선별장으로 입고된 혼합재활용품에서 유가품 선별율은 약 38.85%이며 잔재물은 약 55.90%로 나타났다. 전체 잔재물 7,744.8톤 중 유가품은 약 4,272.1톤이 존재하는 것으로 나타났다. 활용가능한 유가품의 수거효율을 높이기 위한 방안으로는 거점수거 활성화, 선별시설 자동화 및 현대화, 잔재물의 자원화 등이 검토되었다.