• The Korean Journal of Mycology
• /
• v.21 no.1
• /
• pp.23-27
• /
• 1993

Ion effects on $11{\alpha}-hydroxylation$ of progesterone and $5{\alpha}-reduction\;of\;11{\alpha}-hydroxyprogesterone$ by Rhizopus nigricans were investigated. Metal ions such as $Cu^{2+},\;Cd^{2+},\;Co^{2+},\;Mn^{2+},\;Zn^{2+},\;Fe^{2+},\;Mg^{2+},\;Fe^{3+}\;and\;Na^+$ reduced the $11{\alpha}-hydroxylation$ activity, while $K^+$ stimulated the same reaction. Enzyme activity for the $5{\alpha}-reduction$ of $11{\alpha}-hydroxyprogesterone$ was increased in the presence of $Fe^{2+},\;Mn^{2+},\;Mg^{2+},\;Co^{2+},\;Zn^{2+},\;Fe^{3+},\;K^+\;and\;Na^+$, whereas it was decreased in the presence of $Cd^{2+}\;and\;Cu^{2+}$. Potassium ion of $10^{-3}\;M\;$ of concentration was found to be effective for the promotion of $11{\alpha}-hydroxylation$. On the other hand, cadmium ion of $10^{-4}\;M$ was proved to suppress the $5{\alpha}-reduction$ reaction. Progesterone is reported to be transformed into $11{\alpha}-hydroxyprogesterone$ which, in turn, is converted further into $11{\alpha}-hydroxy-allopregnane-3$, 20-dione by R. nigricans. From this point of view, the highest yield of $11{\alpha}-hydroxyprogesterone$ could be obtained when potassium ion of $10^{-3}\;M$ was given initially followed by addition of cadmium ion of $10^{-4}\;M$ to limit conversion of 11{\alpha}-hydroxyprogesterone into $11{\alpha}-hydroxy-allopregnane-\;3$, 20-dione.

• YAKHAK HOEJI
• /
• v.33 no.4
• /
• pp.237-240
• /
• 1989

A new synthetic method for tiaprofenic acid, which is a potent anti-inflammatory agent, was described. Friedel-Crafts reaction of thiophene with ethyl ${\alpha}-chloro-{\alpha}-(methylthio)$ acetate (1) gave ethyl ${\alpha}-methylthio-2-thiopheneacetate$ (3). Ethyl ${\alpha}-methyl-2-thiopheneacetate$ (5) was prepared by treatment of (3) with NaH and MeI, followed by desulfurization with zinc dust-acetic acid of the resultant ethyl ${\alpha}-methyl-{\alpha}-methylthio-2-thiopheneacetate$ (4). Tiaprofenic acid (7) could be easily synthesized by benzoylation of (5) and hydrolysis of the resultant ethyl $5-benzoyl-{\alpha}-methyl-2-thiopheneacetate$ (6).

• Korean Journal of Animal Reproduction
• /
• v.25 no.2
• /
• pp.155-162
• /
• 2001

These experiments were conducted to evaluate the effects of the administration of exogenous PG $F_{2{\alpha}}$ on hormone concentrations and follicular development in early postpartum(pp) Korean native goats. 1. Plasma PG $F_{2{\alpha}}$ concentrations in PG $F_{2{\alpha}}$ treated goals showed a gradual increase from a low on day 2 (GR-1 : 10 day-treatment group: 6.35$\pm$0.5 and GR-2; 4 day-treatment group: 0.22$\pm$0.2 pg/$m\ell$, respectively) to reach a peak of 21.18$\pm$1.6 or 4.21 $\pm$0.4 pg/$m\ell$ on day 4 after treatment of PG $F_{2{\alpha}}$. 2. Plasma PG $F_{2{\alpha}}$ concentrations in GR-1 goats averaged 9.08 $\pm$1.2 pg/$m\ell$ compared with 5.44$\pm$ 1.8 pg/$m\ell$ in GR-2 goats the day before treatment of PG $F_{2{\alpha}}$. Mean PG $F_{2{\alpha}}$ concentrations thereafter remained low during the treatment period but PG $F_{2{\alpha}}$ concentrations did not differ between the two group. 3. Plasma concentrations of estradiol-17 $\beta$ (E,) in PG $F_{2{\alpha}}$ - treated group were decreased gradually until 2 days after PG $F_{2{\alpha}}$ treatment but mean $E_2$ concentrations began to increase on 3 days and were Inaximal on the 4 days after treatment. 4. Plasma lulenizing hormone (LH) concentrations in PG $F_{2{\alpha}}$ - treated goats were slightly higher than in controls but mean LH concentrations did not differ between the two treatment groups. 5. Plasma prolactin (PRL) concentrations were suppressed in both GR-1(10 day-treatment group) and GR-2(4 day-treatment group) goats compared to saline controls but mean PRL concentrations remained lower in PG $F_{2{\alpha}}$ treated animals during post-treatment period. 6. The mean number of small and medium follicles present when PG $F_{2{\alpha}}$ was administrated was similar in all does but the increase in number of large follicles($\geq$4mm) tended to be higher in PG $F_{2{\alpha}}$ treated group than controls. These results suggest that concentrations of PG $F_{2{\alpha}}$ and estradiol-17$\beta$ were positively correlared with follicular diameter. We conclude that PG $F_{2{\alpha}}$ treatment stimulates follicular development similarly in both GR-1 and GR-2 group.

• Bulletin of the Korean Mathematical Society
• /
• v.46 no.2
• /
• pp.331-346
• /
• 2009

Let ${\alpha}$ = (${\alpha}_1,\;{\alpha}_2$,...) and ${\beta}$ = (${\beta}_1,\;{\beta}_2$,...) be two sequences with ${\alpha}_1$ = ${\beta}_1$ and k and n be natural numbers. We denote by $A^{(k,{\pm})}_{{\alpha},{\beta}}(n)$ the matrix of order n with coefficients ${\alpha}_{i,j}$ by setting ${\alpha}_{1,i}$ = ${\alpha}_i,\;{\alpha}_{i,1}$ = ${\beta}_i$ for 1 ${\leq}$ i ${\leq}$ n and $${\alpha}_{i,j}=\{{\alpha}_{i-1,j-1}+{\alpha}_{i-1,j}\;if\;j{\equiv}$$2,3,4,..., k + 1 (mod 2k) $$\{{\alpha}_{i-1,j-1}-{\alpha}_{i-1,j}\;if\;j{\equiv}$$ k + 2,..., 2k + 1 (mod 2k) for 2 ${\leq}$ i, j ${\leq}$ n. The aim of this paper is to study the determinants of such matrices related to certain sequence ${\alpha}$ and ${\beta}$ and some natural numbers k.

• YAKHAK HOEJI
• /
• v.34 no.1
• /
• pp.15-21
• /
• 1990

-4,9-dione derivatives were prepared from $2-chloro-3-({\alpha}-accetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ and 2-chloro-3-N-phenylamino-1,4-naphthoquinone. $2-Chloro-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ was reacted with amines to give $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ derivatives. Subsequent treatment of $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ with sodium ethoxide gave -4,9-dione derivatives. When 2-chloro-3-N-phenylamino-1,4-naphthoquinone reacted with sodium ${\alpha}-cyano$ ethyl acetate, 2-amino-3-ethoxycarbonyl-N-phenyl--4,9-dione was obtained. However, with sodium diethyl malonate, not -4,9-dione but 2-chloro-3-bis-(methoxycarbonyl)-methyl-2H-3-N-phenylamino-1,4-naphthoquinone was obtained.

• Honam Mathematical Journal
• /
• v.27 no.2
• /
• pp.243-250
• /
• 2005

Given operators X and Y acting on a separable Hilbert space ${\mathcal{H}}$, an interpolating operator is a bounded operator A such that AX = Y. We show the following: Let ${\mathcal{L}}$ be a subspace lattice acting on a separable complex Hilbert space ${\mathcal{H}}$. and let $X=(x_{ij})$ and $Y=(y_{ij})$ be operators acting on ${\mathcal{H}}$. Then the following are equivalent: (1) There exists an invertible operator $A=(a_{ij})$ in $Alg{\mathcal{L}}$ such that AX = Y. (2) There exist bounded sequences {${\alpha}_n$} and {${\beta}_n$} in ${\mathbb{C}}$ such that $${\alpha}_{2k-1}{\neq}0,\;{\beta}_{2k-1}=\frac{1}{{\alpha}_{2k-1}},\;{\beta}_{2k}=-\frac{{\alpha}_{2k}}{{\alpha}_{2k-1}{\alpha}_{2k+1}}$$ and $$y_{i1}={\alpha}_1x_{i1}+{\alpha}_2x_{i2}$$ $$y_{i\;2k}={\alpha}_{4k-1}x_{i\;2k}$$ $$y_{i\;2k+1}={\alpha}_{4k}x_{i\;2k}+{\alpha}_{4k+1}x_{i\;2k+1}+{\alpha}_{4k+2}x_{i\;2k+2}$$ for $$k{\in}N$$.

• Honam Mathematical Journal
• /
• v.33 no.1
• /
• pp.115-120
• /
• 2011

Given vectors x and y in a separable complex Hilbert space $\cal{H}$, an interpolating operator is a bounded operator A such that Ax = y. We show the following : Let Alg$\cal{L}$ be a tridiagonal algebra on a separable complex Hilbert space H and let x = ($x_i$) and y = ($y_i$) be vectors in H. Then the following are equivalent: (1) There exists an invertible operator A = ($a_{kj}$) in Alg$\cal{L}$ such that Ax = y. (2) There exist bounded sequences $\{{\alpha}_n\}$ and $\{{{\beta}}_n\}$ in $\mathbb{C}$ such that for all $k\in\mathbb{N}$, ${\alpha}_{2k-1}\neq0,\;{\beta}_{2k-1}=\frac{1}{{\alpha}_{2k-1}},\;{\beta}_{2k}=\frac{\alpha_{2k}}{{\alpha}_{2k-1}\alpha_{2k+1}}$ and $$y_1={\alpha}_1x_1+{\alpha}_2x_2$$ $$y_{2k}={\alpha}_{4k-1}x_{2k}$$ $$y_{2k+1}={\alpha}_{4k}x_{2k}+{\alpha}_{4k+1}x_{2k+1}+{\alpha}_{4k+2}x_{2k+2}$$.

• Microbiology and Biotechnology Letters
• /
• v.10 no.4
• /
• pp.259-265
• /
• 1982

These experiments were conducted to investigate the hydrolysis products on the various oligosaccharides of Bacillus cirulans F-2 $\alpha$-amylase, and the hydrolysis rate on the various raw starches of Bacillus circulans F-2 $\alpha$-amylase, Bacillus amylotiquefaciens $\alpha$-amylase and Rhizopus niveus glucoamylase. The results obtained were as follows : 1. Maltotetraose, maltopentaose, maltohexaose, maltoheptaose and maltooctaose were hydrolyzed, but maltose and maltotriose were not hydrolyzed by Bacillus circulans F-2 $\alpha$-amylase. Among maltotetraose, maltopentaose, maltohexaose, maltoheptaose and maltooctaose, especially maltotetraose was hydrolyzed weakly by Bacillus circulans F-2 $\alpha$-amylase. 2. The Hydrolysis rate of oyster glycogen was slightly lower than soluble starch, amylose and amylopectin. 3. The hydrolysis rate of com starch was higher in shaking incubation than in stationary incubation, but the hydrolysis rate of potato starch was not definite according to kinds of enzyme. 4. On com, rice, arrowroot, high amylose corn, banana, sago, yam and potato starch, Bacillus circulans F-2 $\alpha$-amylase exhibited a remarkably higher hydrolysis rate than Bacillus amyloquefaciems $\alpha$-amylase and Rhizopus niveus glucoamylase.

• YAKHAK HOEJI
• /
• v.37 no.1
• /
• pp.49-53
• /
• 1993

Arylalkanoic acid derivatives are known as good non-steroidal antiinflamatory and antirheumatic agents. The new arylalkanoic acid derivatives were synthesized when 2-chloro-3-($\alpha$-cyano-$\alpha$-ethoxycarbonyl-methyl)-1, 4-naphthoquinone was reacted with some arylamines.

• YAKHAK HOEJI
• /
• v.30 no.3
• /
• pp.157-162
• /
• 1986

$\alpha$-Adrenoceptor subtypes in the isolated rat aortic strips were examined by using agonists and antagonists which have varying selectivity for $\alpha_1$- and $\alpha_2$- adrenoceptors. Norepinephrine and phenylephrine produced a similar magnitude of maximum contractions. $pA_2$ values for prazosin and yohimbine were not significantly different using norepinephrine or phenylephrine as the agonist, suggesting a single population of alpha-adrenoceptor. Contractile responses produced by alpha-agonists were antagonized more effectively by prazosin (approximately 1000 fold) than by yohimbine.