• 한국균학회지
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• 제21권1호
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• pp.23-27
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• 1993

Rhizopus nigricans에 의한 progesterone의 $11{\alpha}-hydroxylation$과 ${5\alpha}-reduction$반응에 미치는 이온의 효과를 조사하였다. $Cu^{2+},\;Cd^{2+},\;Co^{2+},\;Mn^{2+},\;Zn^{2+},\;Fe^{2+},\;Mg^{2+},\;Fe^{3+}$ 및 $Na^+$은 $11{\alpha}-hydroxylation$ 반응의 활성을 저하시켰으나 $K^+$은 이 반응을 촉진시켰다. $11{\alpha}-hydroxyprogesterone$을 $5{\alpha}-reduction$시키는 효소는 $Fe^{2+},\;Mn^{2+},\;Mg^{2+},\;Co^{2+},\;Zn^{2+},\;Fe^{2+},\;K^+,\;Na^+$에 의하여 그 활성이 증가되었고 $Cd^{2+}$과 $Cu^{2+}$은 이 반응을 억제하였다. $11{\alpha}-hydroxylation$ 반응을 촉진하는데는 $10^{-3}\;M$의 $K^+$이 효과적이었으며 $5{\alpha}-reduction$반응을 엑제하기 위하여는 $10^{-4}\;M$의 $Cd^{2+}$이 적합하였다. R. nigricans는 세포내의 다효소체계에 의하여 progesterone이 $11\{alpha}-hydroxyprogesterone$으로 전환된 후 $11{\alpha}-hydroxy-allopregnane-3, 20-dione으로 $5{\alpha}-reduction$되므로 $10^{-3}\;M$의 $K^+$을 먼저 첨가하여 2시간 동안 progesterone 전환 반응을 실시한 후에 $10^{-4}\;M$의 $Cd^{2+}$을 첨가하였을 때 가장 높은 $11\{alpha}-hydroxyprogesterone$의 수득률을 얻을 수 있었다.

• 약학회지
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• 제33권4호
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• pp.237-240
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• 1989

A new synthetic method for tiaprofenic acid, which is a potent anti-inflammatory agent, was described. Friedel-Crafts reaction of thiophene with ethyl ${\alpha}-chloro-{\alpha}-(methylthio)$ acetate (1) gave ethyl ${\alpha}-methylthio-2-thiopheneacetate$ (3). Ethyl ${\alpha}-methyl-2-thiopheneacetate$ (5) was prepared by treatment of (3) with NaH and MeI, followed by desulfurization with zinc dust-acetic acid of the resultant ethyl ${\alpha}-methyl-{\alpha}-methylthio-2-thiopheneacetate$ (4). Tiaprofenic acid (7) could be easily synthesized by benzoylation of (5) and hydrolysis of the resultant ethyl $5-benzoyl-{\alpha}-methyl-2-thiopheneacetate$ (6).

• 한국가축번식학회지
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• 제25권2호
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• pp.155-162
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• 2001

본 실험은 한국재래산양에 있어서 분만 후 초기에 prostaglandin $F_{2{\alpha}}$(PG $F_{2{alpha}$)의 투여가 호르몬 농도 및 난포발육에 미치는 효과를 검토하기 위하여 수행되었던 바 그 결과는 다음과 같다. 1. 분만한 한국재래산양에 혈장중 PG $F_{2{\alpha}}$의 농도는 PG $F_{2{\alpha}}$처리 후 2일에 PG $F_{2{\alpha}}$처리군 (GR-1 및 GR-2)에서 각각 6.35$\pm$0.5 및 0.22$\pm$0.2pg/$m\ell$로서 저하한 후 점차 증가하여 4일 후 21.18$\pm$1.6 및 4.21$\pm$0.4 pg/$m\ell$로서 절정에 도달하였다. 2. 혈장중 PG $F_{2{\alpha}}$의 농도는 PG $F_{2{\alpha}}$ 처리 전 9.08$\pm$1.2 및 5.44$\pm$1.8 pg/$m\ell$였으며 처리후 농도는 다소 저하하였으나 처리 군간에 유의차는 없었다. 3. 혈장중 estradiol-l7$\beta$( $E_2$)농도는 PG $F_{2{\alpha}}$ 처리 후 2일까지 점차 감소한 후 3일에 증가하여 4일에 최대치에 도달하였다. 4. 혈장중 luteinizing hormone (나T)의 농도는 PG $F_{2{\alpha}}$ 처리 후 약간의 증가가 있었으나 유의한 차이는 없었다. 5. 혈장중 prolactin (PRL)의 농도는 PG $F_{2{\alpha}}$처리후 감소되었으나 저농도의 수준으로 남아 있었다. 6. PG $F_{2{\alpha}}$의 처리 후 소형 및 중형의 난포의 수는 거의 유사하였으나 4mm 이상 대형 난포의 수는 숫적로 증가하는 경향을 보였다. 이상의 결과로 보아 PG $F_{2{\alpha}}$ 및 estradiol-17$\beta$는 난포의 직경과 관계가 있다고 암시되며 PG $F_{2{\alpha}}$는 난포발육을 촉진하였다고 생각된다.

• 대한수학회보
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• 제46권2호
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• pp.331-346
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• 2009

Let ${\alpha}$ = (${\alpha}_1,\;{\alpha}_2$,...) and ${\beta}$ = (${\beta}_1,\;{\beta}_2$,...) be two sequences with ${\alpha}_1$ = ${\beta}_1$ and k and n be natural numbers. We denote by $A^{(k,{\pm})}_{{\alpha},{\beta}}(n)$ the matrix of order n with coefficients ${\alpha}_{i,j}$ by setting ${\alpha}_{1,i}$ = ${\alpha}_i,\;{\alpha}_{i,1}$ = ${\beta}_i$ for 1 ${\leq}$ i ${\leq}$ n and $${\alpha}_{i,j}=\{{\alpha}_{i-1,j-1}+{\alpha}_{i-1,j}\;if\;j{\equiv}$$2,3,4,..., k + 1 (mod 2k) $$\{{\alpha}_{i-1,j-1}-{\alpha}_{i-1,j}\;if\;j{\equiv}$$ k + 2,..., 2k + 1 (mod 2k) for 2 ${\leq}$ i, j ${\leq}$ n. The aim of this paper is to study the determinants of such matrices related to certain sequence ${\alpha}$ and ${\beta}$ and some natural numbers k.

• 약학회지
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• 제34권1호
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• pp.15-21
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• 1990

-4,9-dione derivatives were prepared from $2-chloro-3-({\alpha}-accetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ and 2-chloro-3-N-phenylamino-1,4-naphthoquinone. $2-Chloro-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ was reacted with amines to give $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ derivatives. Subsequent treatment of $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ with sodium ethoxide gave -4,9-dione derivatives. When 2-chloro-3-N-phenylamino-1,4-naphthoquinone reacted with sodium ${\alpha}-cyano$ ethyl acetate, 2-amino-3-ethoxycarbonyl-N-phenyl--4,9-dione was obtained. However, with sodium diethyl malonate, not -4,9-dione but 2-chloro-3-bis-(methoxycarbonyl)-methyl-2H-3-N-phenylamino-1,4-naphthoquinone was obtained.

• 호남수학학술지
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• 제27권2호
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• pp.243-250
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• 2005

Given operators X and Y acting on a separable Hilbert space ${\mathcal{H}}$, an interpolating operator is a bounded operator A such that AX = Y. We show the following: Let ${\mathcal{L}}$ be a subspace lattice acting on a separable complex Hilbert space ${\mathcal{H}}$. and let $X=(x_{ij})$ and $Y=(y_{ij})$ be operators acting on ${\mathcal{H}}$. Then the following are equivalent: (1) There exists an invertible operator $A=(a_{ij})$ in $Alg{\mathcal{L}}$ such that AX = Y. (2) There exist bounded sequences {${\alpha}_n$} and {${\beta}_n$} in ${\mathbb{C}}$ such that $${\alpha}_{2k-1}{\neq}0,\;{\beta}_{2k-1}=\frac{1}{{\alpha}_{2k-1}},\;{\beta}_{2k}=-\frac{{\alpha}_{2k}}{{\alpha}_{2k-1}{\alpha}_{2k+1}}$$ and $$y_{i1}={\alpha}_1x_{i1}+{\alpha}_2x_{i2}$$ $$y_{i\;2k}={\alpha}_{4k-1}x_{i\;2k}$$ $$y_{i\;2k+1}={\alpha}_{4k}x_{i\;2k}+{\alpha}_{4k+1}x_{i\;2k+1}+{\alpha}_{4k+2}x_{i\;2k+2}$$ for $$k{\in}N$$.

• 호남수학학술지
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• 제33권1호
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• pp.115-120
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• 2011

Given vectors x and y in a separable complex Hilbert space $\cal{H}$, an interpolating operator is a bounded operator A such that Ax = y. We show the following : Let Alg$\cal{L}$ be a tridiagonal algebra on a separable complex Hilbert space H and let x = ($x_i$) and y = ($y_i$) be vectors in H. Then the following are equivalent: (1) There exists an invertible operator A = ($a_{kj}$) in Alg$\cal{L}$ such that Ax = y. (2) There exist bounded sequences $\{{\alpha}_n\}$ and $\{{{\beta}}_n\}$ in $\mathbb{C}$ such that for all $k\in\mathbb{N}$, ${\alpha}_{2k-1}\neq0,\;{\beta}_{2k-1}=\frac{1}{{\alpha}_{2k-1}},\;{\beta}_{2k}=\frac{\alpha_{2k}}{{\alpha}_{2k-1}\alpha_{2k+1}}$ and $$y_1={\alpha}_1x_1+{\alpha}_2x_2$$ $$y_{2k}={\alpha}_{4k-1}x_{2k}$$ $$y_{2k+1}={\alpha}_{4k}x_{2k}+{\alpha}_{4k+1}x_{2k+1}+{\alpha}_{4k+2}x_{2k+2}$$.

• 한국미생물·생명공학회지
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• 제10권4호
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• pp.259-265
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• 1982

Bacillus circulans F-2 $\alpha$-amylase에 의한 각종 oligosaccharide의 분해산물을 조사하고, Bacillus circulans F-2 $\alpha$-amylase, Bacillus amyloliquefaciens $\alpha$-amylase, Rhizopus niveus glucoamylase에 의한 각종 생전분의 분해율을 비교 검토한 결과를 요약하면 다음과 같다. 1. 공시 oligosaccharide중 Bacillus circuians F-2 $\alpha$-amylase는 maltose와 maltotriose를 분해시키지 못하였으나 meltotetraose이상의 oligosaccharide는 분해시켰다. maltotetraose, maltopentaose, maltoheraose, maltoheptaose, maltooctaose중 maltotetraose의 분해가 가장 미약하였다. 2. soluble starch, amylopectin, amylose, oyster glycogen중 oyster glycogen의 분해율이 약간 낮았다. 3. corn starch의 분해율은 진탕반응이 정치반응보다 높았으나 potato starch에 대하여는 효소의 종류에 따라 일정치 않았다. 4. corn, rice, arrowroot, high amylose corn, banana, sago, yam, potato starch에 대하여 Bacillus circulans F-2 $\alpha$-amylase가 Bacillus amyloquefaciems $\alpha$-amylase, Rhizopus niveus glucoamylase보다 월등하게 높은 분해율을 나타내었다.

• 약학회지
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• 제37권1호
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• pp.49-53
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• 1993

Arylalkanoic acid derivatives are known as good non-steroidal antiinflamatory and antirheumatic agents. The new arylalkanoic acid derivatives were synthesized when 2-chloro-3-($\alpha$-cyano-$\alpha$-ethoxycarbonyl-methyl)-1, 4-naphthoquinone was reacted with some arylamines.

• 약학회지
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• 제30권3호
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• pp.157-162
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• 1986

$\alpha$-Adrenoceptor subtypes in the isolated rat aortic strips were examined by using agonists and antagonists which have varying selectivity for $\alpha_1$- and $\alpha_2$- adrenoceptors. Norepinephrine and phenylephrine produced a similar magnitude of maximum contractions. $pA_2$ values for prazosin and yohimbine were not significantly different using norepinephrine or phenylephrine as the agonist, suggesting a single population of alpha-adrenoceptor. Contractile responses produced by alpha-agonists were antagonized more effectively by prazosin (approximately 1000 fold) than by yohimbine.