• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4067-4069
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• 2013

Background: The present study was undertaken to establish any correlation of elevated levels of CA19-9 with tumor stage or grade of urothelial carcinoma. Materials and Methods: This hospital based study was carried out in the Department of Biochemistry of Nepalese Army Institute of Health Sciences between $1^{st}$ July 2012 and $31^{st}$ December 2012. Approval for the study was obtained from the institutional research ethical committee. CA19-9 was assayed with an ELISA reader for all cases and expressed in U/ml with 37U/ml taken as the cut-off upper value for normal. Results: Out of 20 cases enrolled, 15 were of urothelial carcinoma and the remaining 5 were controls. There was marked difference between the mean values of CA19-9 in cases $40.2{\pm}19.3U/ml$ of urothelial carcinoma and controls $7.98{\pm}7.34U/ml$. The number of cases in Ta, TI, T2, T3, T4 stages of urothelial carcinoma were 2, 6, 3, 3, 1 respectively. The percentage rise in CA19-9 was less with low grade tumors (22.2%) when compared with high grade tumors (66.6%) (p value $0.001^*$). The percentage of rise in CA19-9 for muscle invasive tumors was very high when compared to superficial tumors. Similarly, the percentage of rise in CA19-9 for metastatic disease was very high when compared to non-metastatic disease and it was found statistically significant (p value $0.001^*$). Conclusion: Serum CA19-9 levels predicts the prognosis of urothelial carcinoma as it is almost invariably raised in tumors having metastatic spread.

• 한국동물위생학회지
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• 제42권4호
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• pp.169-175
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• 2019

Naegleria fowleri, a pathogenic free-living amoeba, leads to a fatal infection known as primary amebic meningoencephalitis (PAM) in human and animals. PAM is an acute, fulminant, necrotizing, and hemorrhagic disease that leads to death in approximately seven days. In this study, we investigate the cytotoxicity of target cells and the secreted molecules of N. fowleri under the non-contact condition. The target cell (U87MG cell) treated with N. fowleri lysates showed no morphological changes and no cytotoxicity. By contrast, the U87MG cells co-cultured with N. fowleri trophozoites under the non-contact condition induced morphological changes and reduction in number. When U87MG cells were co-cultured with N. fowleri trophozoites under the non-contact condition for 30 min, 2 hr, and 4 hr, the levels of cytotoxicity of target cells were 32.3, 35.5, and 37.8%, respectively. Particularly, when the ratio of amoeba to target cells is 10 to 1, the level of cytotoxicity of target cells was 49.7% at 30 min. To show the proteins secreted from N. fowleri under the non-contact condition, we carried out 2D electrophoresis and observed 6 major proteins. Finally, these results suggest that the molecules released from N. fowleri under the non-contact condition induce the cell death and this process is an important step in pathogenesis of N. fowleri.

• 천문학회지
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• 제37권5호
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• pp.557-562
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• 2004

We discuss diffusion of particles in turbulent flows. In hydrodynamic turbulence, it is well known that distance between two particles imbedded in a turbulent flow exhibits a random walk behavior. The corresponding diffusion coefficient is ${\~}$ ${\upsilon}_{inj}{\iota}_{turb}$, where ${\upsilon}_{inj}$ is the amplitude of the turbulent velocity and ${\iota}_{turb}$ is the scale of the turbulent motions. It Is not clear whether or not we can use a similar expression for magnetohydrodynamic turbulence. However, numerical simulations show that mixing motions perpendicular to the local magnetic field are, up to high degree, hydrodynamical. This suggests that turbulent heat transport in magnetized turbulent fluid should be similar to that in non-magnetized one, which should have a diffusion coefficient ${\upsilon}_{inj}{\iota}_{turb}$. We review numerical simulations that support this conclusion. The application of this idea to thermal conductivity in clusters of galaxies shows that this mechanism may dominate the diffusion of heat and may be efficient enough to prevent cooling flow formation when turbulence is vigorous.

• Journal of Microbiology
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• 제37권2호
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• pp.66-72
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• 1999

Mycolic acid-containing actinomycetes associated with extensive foaming in the aeration basin of the activated sludge process were isolated and analyzed by phenotypical, chemotaxonomical and phylogenetic methods. Whole cell sugar patterns of two isolates were pattern A. The nearly complete sequences of the 16S rRNA genes (rDNAs) of the isolates were determined and compared by using several tree-making algorithms. With polyphasic methods, strain SCNU1 was identified as Gordona sputi, and strain SCNU5 assigned to the genus Tsukamurella. The presence of opportunistic pathogens of chronic lung infections within foams can cause public health problems and render waste-treatment processes inefficient.

• Journal of Microbiology and Biotechnology
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• 제17권1호
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• pp.74-80
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• 2007

An enantioselective lipase gene (esf) for the kinetic resolution of optically active (S)-flurbiprofen was cloned from the new strain Serratia marcescens ES-2. The esf gene was composed of a 1,845-bp open reading frame encoding 614 amino acid residues with a calculated molecular mass of 64,978 Da. The lipase expressed in E. coli was purified by a three-step procedure, and it showed preferential substrate specificity toward the medium-chain-length fatty acids. The esf gene encoding the enantioselective lipase was reintroduced into the parent strain S. marcescens ES-2 for secretory overexpression. The transformant S. marcescens BESF secreted up to 217kU/ml of the enantioselective lipase, about 54-fold more than the parent strain, after supplementing 3.0% Triton X-207. The kinetic resolution of (S)-flurbiprofen was carried out even at an extremely high (R,S)-flurbiprofen ethyl ester [(R,S)-FEE] concentration of 500 mM, 130 kU of the S. marcescens ES-2 lipase per mmol of (R,S)-FEE, and 1,000 mM of succinyl ${\beta}-cyclodextrin$ as the dispenser at $37^{\circ}C$ for 12h, achieving the high enantiomeric excess and conversion yield of 98% and 48%, respectively.

• Advances in Energy Research
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• 제4권1호
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• pp.1-28
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• 2016

A grid-connected photovoltaic (PV) system comprised of multicrystalline silicon (mc-Si) modules was installed in a cold climate region in the U.S. This roof-mounted stationary PV system is a real-world application of PV for building energy generation in International Energy Conservation Code (IECC) Climate Zone 5 (and possibly similar climate zones such as 6, 7 and 8), and it served the purposes of research, demonstration, and education. The importance of this work is highlighted by the fact that there has been less emphasis on solar PV system in this region of the U.S. because of climate and latitude challenges. The system is equipped with an extensive data acquisition system capable of collecting performance and meteorological data while visually displaying real-time and historical data through an interactive online interface. Experimental data was collected and analyzed for the system over a one-year period with the focus of the study being on measurements of power production, energy generation, and efficiency. The annual average daily solar insolation incident upon the array was found to be $4.37kWh/m^2$. During the first year of operation, the PV system provided 5,801 kWh (1,264 kWh/kWp) of usable AC electrical energy, and it was found to operate at an annual average conversion efficiency and PR of 10.6 percent and 0.79, respectively. The annual average DC to AC conversion efficiency of the inverter was found to be 94 percent.

• 천문학회보
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• 제37권2호
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• pp.84.2-84.2
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• 2012

We present wide-field multiband photometry of globular cluster (GC) systems toward the central region of the Fornax cluster of galaxies, including NGC 1399, NGC 1404, and NGC 1387. Observation was carried out through four optical passbands (U, B, V, and I) with the Mosaic II CCD imager mounted on the 4-m Blanco telescope at Cerro Tololo Inter-American Observatory (CTIO). This marks one of the widest U-band photometric studies on GC systems. GC candidates are selected among point sources based on their two color diagrams together with a magnitude cut. We investigate the radial variation of color distributions for the GC systems, focusing on the fundamental parameters that characterize bimodal distributions; the number ratio between blue and red GCs, the mean colors of the groups, and their color dispersions. We discuss the implication of our result regarding the origin of GC color bimodality.

• 아동학회지
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• 제37권6호
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• pp.157-168
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• 2016

Objective: This study examined the intellectual characteristics of 1,700 Korean children aged 2 years, 6 months to 7 years, 7 months across two age ranges (2 years, 6 months to 3 years, 11 months; 4 years to 7 years, 7 months). Methods: Data from the standardization study of the K-WPPSI-IV were analyzed using Korean and American norms and in terms of socioeconomic variables such as region, maternal education level, and child gender. Results: Korean children performed differently from their American counterparts in most subtests and indexes. Verbal subtest performances for Korean children were significantly lower and performance subtest performances for Korean children were significantly higher. There were significant regional differences, with higher performances among children from Seoul than from other areas. Children whose mothers had higher education levels showed higher performances than their counterparts. This trend was more apparent in the older age range. Gender differences were found in most subtests, with girls showing higher scores than boys. Conclusion: This study revealed cross-cultural differences in intellectual characteristics measured with the newly standardized K-WPPSI-IV. In addition, significant effects of socioeconomic variables such as region, maternal education level, and gender were found.

• 대한물리의학회지
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• 제14권4호
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• pp.37-44
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• 2019

PURPOSE: The purpose of this study was to compare sitting balance and coordination spastic cerebral palsy in children using the Korean version of Trunk Impairment Scale (K-TIS) as well as to provide basic data about effective postural control treatment for clinicians handling these two types. METHODS: The K-TIS was measured in 29 children diagnosed with diplegic and quadriplegic cerebral palsy (18 with diplegia and 11 with quadriplegia). The average and standard scores of the children's K-TIS subscales and items of the two groups were measured. The two groups' subscales and items were analyzed by using the Mann-Whitney U test. RESULTS: Static sitting balance, dynamic sitting balance, coordination, and total score for children with diplegia were statistically high (p<.05). For all items under static sitting balance, the score for children with diplegia was higher. The first differences in the repeated items of dynamic sitting balance and coordination area that rotates between the upper and lower body were presented. CONCLUSION: The difference in balance and coordination in sitting positions is exhibited in children with diplegia and quadriplegia. For children with spastic quadriplegia, treatments should focus on static sitting balance and coordination, together with a focus on dynamic sitting balance and coordination.

• 한국해양학회지
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• 제27권3호
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• pp.237-246
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• 1992

서해 중동부 연안수역과 경기만에서 식물플랑크톤에 의한 일차 생산력과 동화계수 에 영향을 주는 요소들을 규명하고자 1989년 3월부터 1990년 10월까지 chl-a 농도, 광 조건, 수온, 염분도 및 투명도 등을 현장에서 조사하였다. 식물플랑크톤에 의한 chl-a 농도는 서해 중등부 연안수역에서 0.78~4.79 ug/l이었으며, 경기만에서는 0.91~4.3 ug/l의 변화폭을 보였다. 서해 중등부 연안수역에서 일일 평균 일일 생산력과 년 평균 생산력은 각각 37.23~1104.44(평균 361.54) mgC/m$^2$/d,131.96 mgC/m$^2$/yr이었으며 경 기만에서는 37.01~1028.46(평균236.89)mgC/m$^2$/d,86.46mgC/m$^2$/yr 으로 서해 중동부 연안수역이 경기만보다 다소 높게 측정되었다. 동화계수는 살펴보면 서해 중동부 연안 수역에서는 1.13~11.03mgC/mg chl-a/hr 이었으며, 경기만에서는 1.47~24.28mgC/mg chl-a/hr으로 조사되어 경기만이 다소 높게 측정되었다. 연구대상 해역에서는 다른 해 역에 비해 조사된 측정치들이 다소 높게 나타났다. P-I curve에서의 a(light utilization efficiency)는 서해 중동부 연안 수역에서 0.01~0.62[mgC/mg chl-a/hr] 이었으며, 경기만에서는 0.03~0.93[mgC/mg chl-a/hr]/[uE/m$^2$/sec]으로 조사되어 경 기만에 출현하는 식물플랑크톤이 좀더 빚을 효율적으로 이용하는 것으로 나타났다. 빛 에 대한 식물플랑크톤의 생리적인 적응상태를 지시하는 I/SUB k/값은 서해 중동부 연 안수역에서 평균120.37uE/m$^2$/sec 이었으며, 경기만에서는 48.35uE/m$^2$/sec으로 측정 되어, 경기만에서 출현하는 식물플랑크톤이 서해 중동부 연안수역에서 출현하는 식물 플랑크톤보다 상대적으로 낮은 광에 적응되어 있었다.