• Structural Engineering and Mechanics
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• 제71권3호
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• pp.245-255
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• 2019

In this paper, an inverted-pendulum model consisting of a point supported by spring limbs with roller feet is adopted to simulate human walking load. To establish the kinematic motion of first and second single and double support phases, the Lagrangian variation method was used. Given a set of model parameters, desired walking speed and initial states, the Newmark-${\beta}$ method was used to solve the above kinematic motion for studying the effects of roller radius, stiffness, impact angle, walking speed, and step length on the ground reaction force, energy transfer, and height of center of mass transfer. The numerical simulation results show that the inverted-pendulum model for walking is conservative as there is no change in total energy and the duration time of double support phase is 50-70% of total time. Based on the numerical analysis, a dynamic load factor ${\alpha}_{wi}$ is proposed for the traditional walking load model.

• Biomolecules & Therapeutics
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• 제27권2호
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• pp.178-184
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• 2019

Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether ${\beta}-Lapachone$ (${\beta}-LAP$), a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia avellanedae), elicits neuroprotective effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model. ${\beta}-LAP$ reduced the tyrosine hydroxylase (TH)-immunoreactive fiber loss induced by MPTP in the dorsolateral striatum, and alleviated motor dysfunction as determined by the rotarod test. In addition, ${\beta}-LAP$ protected against MPTP-induced loss of TH positive neurons, and upregulated B-cell lymphoma 2 protein (Bcl-2) expression in the substantia nigra. Based on previous reports on the neuroprotective role of nuclear factor-E2-related factor-2 (Nrf2) in neurodegenerative diseases, we investigated whether ${\beta}-LAP$ induces upregulation of the Nrf2-hemeoxygenae-1 (HO-1) signaling pathway molecules in MPTP-injected mouse brains. Western blot and immunohistochemical analyses indicated that ${\beta}-LAP$ increased HO-1 expression in glial fibrillary acidic protein-positive astrocytes. Moreover, ${\beta}-LAP$ increased the nuclear translocation and DNA binding activity of Nrf2, and the phosphorylation of upstream adenosine monophosphate-activated protein kinase (AMPK). ${\beta}-LAP$ also increased the localization of p-AMPK and Nrf2 in astrocytes. Collectively, our data suggest that ${\beta}-LAP$ exerts neuroprotective effect in MPTP-injected mice by upregulating the p-AMPK/Nrf2/HO-1 signaling pathways in astrocytes.

• 재무관리연구
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• 제24권4호
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• pp.75-106
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• 2007

본 연구는 유가요인이 업종별 주식수익률 결정요인으로 작용하는 지 여부와 유가요인과의 공분산 리스크가 업종별로 차이가 나는 원인에 관해서 분석하였다. 첫째, 업종별로 주식의 기대수익률이 유가요인에 대한 리스크프리미엄의 함수로 결정되는 지 여부를 분석하기 위한 검증모형으로 시장 포트폴리오, 국제유가요인으로 구성된 Two-factor APT를 사용하였다. 또한, 베타리스크에 영향을 주는 유가변동률 분산의 주식 수익률로의 전이현상도 함께 살펴보았다. 유가변동성의 비대칭성을 감안하여 GJR을 해당분석의 검증모형으로 사용하였다. 분석결과 전기 전자업종에서 유가요인은 독립적인 가격결정요인임이 입증되었고, 동업종에서만 유가변동성의 주식수익률로의 전이효과가 통계적으로 유의한 것으로 나타났다. 둘째, 유가요인과의 공분산 리스크가 업종별로 차이가 나는 원인을 분석하기 위해 두가지 분석과정이 고려되었다. 첫 번째로 규모 및 유동성을 나타내는 대리변수를 통제변수로 고려하여 업종별로 유가요인에 대한 베타리스크 존재여부를 확인하였다. 두 번째로 유동성 및 규모의 차이와 유가요인에 대한 베타와의 관계를 체계적으로 규명하고자 시계열로 구성된 횡단면 자료간의 관련성을 효율적으로 분석할 수 있는 Panel-data model을 이용하였다. 분석결과 시가총액 비중이 큰 전기 전자업종에서만 유가요인이 독립적 가격결정요인임이 확인되었고, 여타 업종에서 유가요인에 대한 베타리스크는 규모에 영향을 받는 것으로 나타났다. 또한, 패널분석결과 전체 포트폴리오에서 차지하는 업종별 시가총액의 비중이 클수록 유가요인에 대한 베타는 증가하는 것으로 나타나 첫 번째 분석과정의 결과를 지지하였다. 결론적으로 국내주식시장에서 전기 전자업의 기대수익률은 시장포트폴리오와 국제유가요인에 대한 리스크프리미엄의 함수로 결정되고 있으며, 유가요인에 대한 베타리스크 수준이 업종별로 차이가 나는 원인은 규모의 차이에 기인하는 것으로 분석된다.

• 지역사회간호학회지
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• 제12권3호
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• pp.557-569
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• 2001

The purpose of the study was to test the Pender's New Health Promotion Model in order to explain and predict female workers' health promotion behavior at manufacturing plants by using latent variable structural equation model. The data were collected from 280 female workers at 8 electronic factories located at Seoul. Kyunggi. and Incheon using a structured questionnaire through interview and self-report. LISREL was used to test the model. The results are as follows: 8 out of 15 paths of the modified one from the hypothetical model of Health Promotion were statistically significant and the total variance was 40%. The relationship between the previous health behavior and the cognitive emotional factor, and the interpersonal factor. and the situational factor each. and the relationship between perceived health status and interpersonal factor, and health promotion behavior each among gamma paths were unidirectional. On the beta paths. the relationship between the interpersonal factor and the cognitive emotional factor was bi-directional: the relationships amongst the interpersonal factor and the commitment to action, and the health promotion behavior were unidirectional. But the commitment to action was not a significant mediating factor to the health promotion behavior. Pender's New Model is considered good to explain and predict the female workers' health promotion behavior. The interpersonal factor should be considered in occupational nursing practice. But the concepts of situation and commitment to action should be further validated and measured.

• 지역사회간호학회지
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• 제30권1호
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• pp.11-24
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• 2019

Purpose: This study tries to systematically understand factors that explain levels of happiness among pregnant women in the Ecological systems theory. Methods: A descriptive, cross-sectional study was conducted with 169 pregnant women in Korea. Collected data from self-report questionnaires were analyzed by hierarchical regression analysis using the SPSS statistics 23 program. Results: A total of 5 models were examined according to individual, microsystem, mesosystem, exosystem, and macrosystem in the Ecological systems theory. In the first model including individual factors, extraversion, neuroticism, and physical and psychological change constitute significant factors explaining happiness. In the second model with microsystem factors and in the third one with mesosystem factors, marital intimacy appears to be a significant factor. In the fourth model including exosystem factors, community service is a significant factor. In the final model with social atmosphere, personality (${\beta}=.15$ for extraversion; ${\beta}=-.30$ for neuroticism), physical and psychological change (${\beta}=-.15$), marital intimacy (${\beta}=.35$), and community service (${\beta}=.18$) turn out to be significant. These factors explain 59% of the variance of happiness in the pregnant women in Korea. Conclusion: Considering the fact that pregnant women's happiness is explained by microsystem and exosystem factors as well as individual factors, developing intervention programs that can promote influencing factors such as marital intimacy and community service is necessary to improve levels of happiness among pregnant women in Korea.

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.145-150
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• 2017

This study aims to analyze panel data using OECD Health data of 34 years to examine how significant the inequality of income is to the inequality of health. The data was from OECD's pooled Health data of 32 countries from 1980 to 2013. The process of determining analysis model was as follows; First, through the descriptive statistics, we examined averages and standard deviation of variables. Second, Lagrange multiplier test has done. Third, through the F-test, we compared Least squares method and Fixed effect model. Lastly, by Hausman test, we determined proper model and examined effective factor using the model. As a result, rather than Pooled OLS Model, Fixed Effect Model was shown as effective in order to consider the characteristics of individual in the panel. The results are as follows: First, as relative poverty rate(${\beta}=-19.264$, p<.01) grows, people's life expectancy decreases. Second, as the rate of smoking(${\beta}=-.125$, p<.05) and the rate of unemployment (${\beta}=-.081$, p<.01) grows, people's life expectancy decreases. Third, as health expenditure(${\beta}=.414$, p<.01) shares more amount of GDP and as the number of hospital beds(${\beta}=-.190$, p<.05) grows, people's life expectancy increases.

• Bulletin of the Korean Chemical Society
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• 제31권7호
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• pp.1920-1926
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• 2010

Yoon et $al.^1$ presented an approximate mathmatical model to describe ammonia removal from an experimental batch reactor system with gaseous headspace. The development of the model was initially based on assuming instantaneous equilibrium between ammonia in the aqueous and gas phases. In the model, a "saturation factor, $\beta$" was defined as a constant and used to check whether the equilibrium assumption was appropriate. The authors used the trends established by the estimated $\beta$ values to conclude that the equilibrium assumption was not valid. The authors presented valuable experimental results obtained using a carefully designed system and the model used to analyze the results accounted for the following effects: speciation of ammonia between $NH_3$ and $NH^+_4$ as a function of pH; temperature dependence of the reactions constants; and air flow rate. In this article, an alternative model based on the exact solution of the governing mass-balance differential equations was developed and used to describe ammonia removal without relying on the use of the saturation factor. The modified model was also extended to mathematically describe the pH dependence of the ammonia removal rate, in addition to accounting for the speciation of ammonia, temperature dependence of reactions constants, and air flow rate. The modified model was used to extend the analysis of the original experimental data presented by Yoon et $al.^1$ and the results matched the theory in an excellent manner.

• 한국산학기술학회논문지
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• 제20권5호
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• pp.241-251
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• 2019

본 연구에서는 Alzheimer's disease(AD) 마우스 모델에서 미세전류의 적용을 통한 인지능력 개선 효과를 확인하였다. ICR 마우스에 amyloid beta($A{\beta}$)를 뇌 내 주입하여 인지능력 손상을 유도한 후, 4가지 파형의 미세전류를 각각 적용하여 손상된 인지능력에 미치는 미세전류의 영향을 검토하였다. AD 마우스의 공간 및 물체 인지능력을 확인하기 위해 행동실험을 실시한 결과, novel object recognition test와 Morris water maze test에서 $A{\beta}$로 인해 손상되었던 인지능력이 미세전류 적용군에서 유의적으로 개선됨을 확인하였으며, 지질과산화 반응으로 인한 malondialdehyde의 뇌 내 생성량 또한 감소하였다. 뇌 조직에서 AD 관련 단백질 발현을 측정한 결과, 특히 미세전류 Wave4 [STEP FORM 파형(0, 1.5, 3, 5V), 중첩Hz 적용] 적용군에서 $A{\beta}$ 생성 관련 단백질인 ${\beta}$-secretase, presenilin 1, presenilin 2의 발현이 감소하였고 신경영양인자인 brain-derived neurotrophic factor 단백질 발현이 증가하였다. 이 결과를 바탕으로 AD 마우스에서 미세전류를 이용한 손상된 인지능력에 대한 개선 효과를 확인하였으며, AD 예방 및 치료를 위한 비약물적인 방법으로서 적용할 수 있을 것으로 기대된다.

• 한국산학기술학회논문지
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• 제13권12호
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• pp.5901-5908
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• 2012

이 연구는 물리치료사 470명을 대상으로 미국물리치료사협회에서 개발한 물리치료 전문직관을 번안하여 이 측정도구의 구성타당도와 신뢰도를 알아보기 위해 실시되었다. 확인적 요인분석을 통해 구성타당도를 알아보았고, 문항내적합치도를 통해 신뢰도를 분석하였다. 번안된 물리치료 전문직관 측정도구는 모형이 적합한 것으로 나타났고(p<.05), 7개요인(역할유연성, 이타주의, 동정/배려, 우수성, 도덕성, 전문가적 책무, 사회적 책무)으로 확인되었다. 구성요인의 표준화계수는 도덕성(${\beta}$=.93), 전문가적 책무(${\beta}$=.92), 동정/배려(${\beta}$=.86) 순으로 높았다. 성별에 따른 전문직관의 차이는 없었으나(p>.05) 임상경력에 따라서는 유의한 차이가 있었다(p<.05). 또한 전문직관은 문항내적합치도가 매우 높았다(Cronbach ${\alpha}$=.80~.96). 번안된 물리치료 전문직관은 구성타당도와 신뢰도가 있는 것으로 나타났기 때문에, 물리치료 전문직관을 측정하는 도구로 유용할 것으로 여겨진다.

• 보건의료산업학회지
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• 제13권3호
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• pp.13-26
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• 2019

Objectives: To investigate whether medical institutions can prevent accidents by analyzing the root cause of a medical accident and identifying the tendencies. Methods: A total of 345 medical cases were used for the RCA(Root Cause Analysis). The root causes were classified using the SHELL model. The suitability of the model was confirmed by SPSS's MDPREF and Euclidean distance. An SPSS20.0 hierarchical regression analysis was used as an influencing factor on the degree of injury resulting from medical accidents. Results: The SHELL model was suitable for classification. The rates of accident causes were LS49%, L34%, LL10.2%, LE3.7%, LH2.3%. The order in which the degree of a patient's injury was affected were: Risk Threshold (${\beta}=.180$), Time (${\beta}=.175$), Surgical stage (${\beta}=-.166$), Do not use procedure (${\beta}=.147$). Conclusions: Health care institutions should remove priorities through system improvement and training. For patients' safety, the five factors of the SHELL model should be managed in harmony.