• 제목/요약/키워드: ${\alpha}_s$-method

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Synthesis of Novel Alkyl $\alpha$-Anilinophenylacetate Derivatives Using Hydrolysis of Hydantoin Ring and Its O-Alkylation

  • Park, Hae-Sun;Park, Myung-Sook;Choi, Hee-Jeon;Kwon, Soon-Kyoung
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.244.2-244.2
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    • 2003
  • For the development of new synthetic method for unnatural amino acid esters, alkyl ${\alpha}$-anilinophenylacetates were synthesized through base-catalyzed hydrolysis of 1,5-diphenylhydantoins in methanol and O-alkylation of sodium ${\alpha}$-anilinophenylacetate with alkyl halides in DMF. Even though hydrolysis of hydantoin ring was undertaken under about 30-40$^{\circ}C$ in methanol, the hydantoic acid sodium salt was continuously converted to the sodium ${\alpha}$-anilinophenylacetate. (omitted)

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면역화학적 방법에 의한 Acetobacter turbidans의 $\alpha$-Acylamino-$\beta$-lactam Acylhydrolase의 유전자 클론화 (Molecular Cloning of the Gene for $\alpha$-Acylamino-$\beta$-lactam Acylhydrolase from Acetobacter turbidans by Immunochemical Detection Method)

  • Nam, Doo-Hyun;Dewey D.Y. Ryu
    • 한국미생물·생명공학회지
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    • 제16권5호
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    • pp.363-368
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    • 1988
  • 반합성 베타 락탐 항생물질의 가수분해 및 합성을 촉매하는 효소인 $\alpha$-acylamino-$\beta$-lactam acylhydrolase(ALAH)의 유전자를 Acetobacfer turbidans로부터 클론화하기 위한 연구를 수행하였다. 우선 순수 분리 정제된 효소에 대한 항혈청 (폴리클론 항체)을 제조한 다음 이를 probe로 하여 면역화학적 방법으로 유전자의 선별을 시도하였다. 이러한 용도로 개발된 운반체인 λ gtll에다 A. turbidans의 유전자 단편들을 삽입하여 genomic library를 제조한 후 이 library에서 유전자를 선별한 결과 두개의 positive clone을 얻을 수 있었다. 그러나. 이 두 clone들은 면역화학적으로 서로 다른 반응을 나타내었는데, 그 중 하나는 효소의 항혈청과는 잘 결합하나 융합되어진 베타 갈락토시다아제에 대한 항체와는 잘 결합하지 못하였고(λ gtll dn1), 또 다른 clone 은 이와 반대의 양상을 보여주었다(λ gtll dn2). 더구나 이들 clone을 여러 제한효소들로 분석해본 결과, 유전자가 삽입된 부분인 Eco RI 부위중 하나가 없어진 것을 알 수 있었다. 따라서 A. turbidans의 효소에 대한 유전자가 λ gtll에 클론화 되었으나 이 유전자와 베타 갈락토시다아제의 유전자(lacZ)간에 염기배열상 동위성이 있은 부위가 존재하여 재조합된 λ gtll 파지의 복제과정에서 삭제되어진 것으로 간주되어진다.

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Chloromethylation of Naphthalene and Mathematical Planning of Experiment for Revealing Optimal Synthetic Conditions

  • V.V. Pak;R.K. Karimov;Kh.M. Shakhidoyatov;L.M. Yun;Soh, Dea-Wha
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2004년도 SMICS 2004 International Symposium on Maritime and Communication Sciences
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    • pp.36-37
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    • 2004
  • $\alpha$-Chloromethylnaphthalene is a valuable compound for obtaining of the plant growing stimulator - $\alpha$-napthylacetic acid. Chloromethylation of naphthalene by paraformaldehyde in the presence of glacial acetic acid, phosphoric and hydrochloric acids at temperature 80-85$^{\circ}C$ and duration - 6 hours the $\alpha$-chloromethyl-naphthalene yield was 55-57%. Using Box-Wilson method for mathematical planning of experiment carried out optimization of its synthesis for purpose increasing $\alpha$-chloromethylnaphthalene yield. Preliminary, one - factor experiments were carried out for selecting independence main parameters influencing on the synthesis. A full factor experiment of 2$^3$with extended matrix of planning was used for optimization. Aiming to increase the $\alpha$-chloromethylnaphthalene yield, the obtained mathematical model was used for program of sharp raising on the reply surface. The received optimal conditions for the $\alpha$-chloromethylnaphthalene synthesis were selected as following: molar ratio of naphthalene - parapfsormaldehyde of 1 : 2; temperature -105$^{\circ}C$; duration of the reaction -3 hours. The yield of $\alpha$-chloromethylnaphthalene under these optimal conditions was 75 %.

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A New Prediction Method for Scintillation Expression

  • Chutchavong, Vanvisa;Nakasuwan, Jintana;Sangaroon, Ornlarp;Jenchitrapongvej, Kanok
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2003년도 ICCAS
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    • pp.2082-2086
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    • 2003
  • This paper presents the analysis of satellite received signal by focus on the new prediction method for amplitude scintillation expression. A predict method based in the relationship of standard deviation values and the peak to peak values of amplitude scintillation in various of time period and various of sampling rate of signal variation. The principal techniques finding, the proper sampling rate and time interval, for the best expression method. The experiment has been performed in Bangkok of Thailand, at King Mongkut's Institute of Technology, Ladkrabang, data collected in C-Band and Ku-Band on high elevation angles. The result of analysis shows the relationship between two methods is given by ${\sigma}_x={\alpha}(P-P)+{\beta}$. The value of ${\alpha}$ depends on sampling rate by closely with three-minute maximum time interval.

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PRECONDITIONED GAUSS-SEIDEL ITERATIVE METHOD FOR Z-MATRICES LINEAR SYSTEMS

  • Shen, Hailong;Shao, Xinhui;Huang, Zhenxing;Li, Chunji
    • 대한수학회보
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    • 제48권2호
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    • pp.303-314
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    • 2011
  • For Ax = b, it has recently been reported that the convergence of the preconditioned Gauss-Seidel iterative method which uses a matrix of the type P = I + S (${\alpha}$) to perform certain elementary row operations on is faster than the basic Gauss-Seidel method. In this paper, we discuss the adaptive Gauss-Seidel iterative method which uses P = I + S (${\alpha}$) + $\bar{K}({\beta})$ as a preconditioner. We present some comparison theorems, which show the rate of convergence of the new method is faster than the basic method and the method in [7] theoretically. Numerical examples show the effectiveness of our algorithm.

고체표면에 도포한 도료 박막의 열전도율과 열확산율의 측정법 (The Measurement Method of Thermal Conductivity and Diffusivity of Thin Paint Layer Sprayed on Solid Surface)

  • 김은영;박수천;김병문;이덕복
    • 대한기계학회논문집B
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    • 제23권3호
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    • pp.311-319
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    • 1999
  • The thermal conductivity ${\lambda}_b$, thermal diffusivity ${\alpha}_b$ of the thin black paint layer sprayed on solid surface and absorptivity a for laser beam are measured by applying a non-contact measurement method of the thermophysical properties of solids. The values of a=0.67, ${\lambda}_b=1.45W/mK$ and ${\alpha}_b=1.24{\times}10^{-6}m^2/s$ are obtained for the sprayed lay~ thickness $z_b{\fallingdotseq}40\;{\mu}m$. Furthermore, for the $z_b{\fallingdotseq}24\;{\mu}m$ thick layers which arc formed by rubbing with a glass rod after spraying, the values of a=0.73, ${\lambda}_b=1.85W/mK$. and ${\alpha}_b=1.09{\times}10^{-6}m^2/s$ are obtained. It is also shown that the present thermal diffusivity ${\alpha}_b$ for $z_b{\fallingdotseq}40\;{\mu}m$ Is about 30~80% larger than those obtained by Araki et al. for the thicker layer $z_b{\fallingdotseq}150{\sim}248\;{\mu}m$. This method could be applied to the measurement of thermophysical properties of thin layer on solids.

A NEW APPROACH FOR RANKING FUZZY NUMBERS BASED ON $\alpha$-CUTS

  • Basirzadeh, Hadi;Abbasi, Roohollah
    • Journal of applied mathematics & informatics
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    • 제26권3_4호
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    • pp.767-778
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    • 2008
  • Comparison between two or more fuzzy numbers, along with their ranking, is an important subject discussed in scholarly articles. We endeavor in this paper to present a simple yet effective parametric method for comparing fuzzy numbers. This method offer significant advantages over similar methods, in comparing intersected fuzzy numbers, rendering the comparison between fuzzy numbers possible in different decision levels. In the process, each fuzzy number will be given a parametric value in terms of $\alpha$, which is dependent on the related $\alpha$-cuts. We have compared this method to Cheng's centroid point method [5] (The relation of calculating centroid point of a fuzzy number was corrected later on by Wang [12]). The proposed method can be utilized for all types of fuzzy numbers whether normal, abnormal or negative.

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Jensen's Alpha Estimation Models in Capital Asset Pricing Model

  • Phuoc, Le Tan
    • The Journal of Asian Finance, Economics and Business
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    • 제5권3호
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    • pp.19-29
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    • 2018
  • This research examined the alternatives of Jensen's alpha (α) estimation models in the Capital Asset Pricing Model, discussed by Treynor (1961), Sharpe (1964), and Lintner (1965), using the robust maximum likelihood type m-estimator (MM estimator) and Bayes estimator with conjugate prior. According to finance literature and practices, alpha has often been estimated using ordinary least square (OLS) regression method and monthly return data set. A sample of 50 securities is randomly selected from the list of the S&P 500 index. Their daily and monthly returns were collected over a period of the last five years. This research showed that the robust MM estimator performed well better than the OLS and Bayes estimators in terms of efficiency. The Bayes estimator did not perform better than the OLS estimator as expected. Interestingly, we also found that daily return data set would give more accurate alpha estimation than monthly return data set in all three MM, OLS, and Bayes estimators. We also proposed an alternative market efficiency test with the hypothesis testing Ho: α = 0 and was able to prove the S&P 500 index is efficient, but not perfect. More important, those findings above are checked with and validated by Jackknife resampling results.

FRACTIONAL HAMILTON-JACOBI EQUATION FOR THE OPTIMAL CONTROL OF NONRANDOM FRACTIONAL DYNAMICS WITH FRACTIONAL COST FUNCTION

  • Jumarie, Gyu
    • Journal of applied mathematics & informatics
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    • 제23권1_2호
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    • pp.215-228
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    • 2007
  • By using the variational calculus of fractional order, one derives a Hamilton-Jacobi equation and a Lagrangian variational approach to the optimal control of one-dimensional fractional dynamics with fractional cost function. It is shown that these two methods are equivalent, as a result of the Lagrange's characteristics method (a new approach) for solving non linear fractional partial differential equations. The key of this results is the fractional Taylor's series $f(x+h)=E_{\alpha}(h^{\alpha}D^{\alpha})f(x)$ where $E_{\alpha}(.)$ is the Mittag-Leffler function.

A STUDY ON CONVERGENCE OF EXTENDED LEAP-FROGGING NEWTON'S METHOD LOCATING MULTIPLE ZEROS

  • Geum, Young Hee
    • 충청수학회지
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    • 제22권2호
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    • pp.217-227
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    • 2009
  • Assuming that a given nonlinear function f : $\mathbf{R}{\rightarrow}\mathbf{R}$ has a zero $\alpha$with integer multiplicity $m{\geq}1$ and is sufficiently smooth in a small neighborhood of $\alpha$, we define extended leap-frogging Newton's method. We investigate the order of convergence and the asymptotic error constant of the proposed method as a function of multiplicity m. Numerical experiments for various test functions show a satisfactory agreement with the theory presented in this paper and are throughly verified via Mathematica programming with its high-precision computability.

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