• 사상체질의학회지
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• 제15권2호
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• pp.129-136
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• 2003

Diabetic nephropathy is defined that renal glomeruluses are damaged by diabetes melitus and proteins that are not excreted to urine normally are exhausted, or do not excrete waste matter to urine, so-called chronic renal failure state. Clinical stage is explained divided 5. If reached 4 or 5 stage, overt proteinuria is occurred to clinical nephropathy, and hypoalbuminemia, azotemia, hypertension, and edema become serious. Concept about edema is differing comprehension about mechanism of a disease, and treatment methodaccording to Sasang Constitution in Sasang Constitutional Medicine. I treated edemtous Soyangin(少陽人) patient with Dojeokgangkitang(導赤降氣湯) who diagnosed as diabetic nephropathy and wrongly treated in Soeumin. I have got good results, so I do case study.

• International Journal of Oral Biology
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• 제35권3호
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• pp.129-135
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• 2010

Recent studies have implicated reactive oxygen species (ROS) as determinants of the pathological pain caused by the activation of peripheral neurons. It has not been elucidated, however, how ROS activate the primary sensory neurons in the pain pathway. In this study, calcium imaging was performed to investigate the effects of NaOCl, a ROS donor, on the intracellular calcium concentration ($[Ca^{2+}]i$) in acutely dissociated dorsal root ganglion (DRG) neurons. DRG was sequentially treated with 0.2 mg/ml of both protease and thermolysin, and single neurons were then obtained by mechanical dissociation. The administration of NaOCl then caused a reversible increase in the $[Ca^{2+}]i$, which was inhibited by pretreatment with phenyl-N-tertbuthylnitrone (PBN) and isoascorbate, both ROS scavengers. The NaOCl-induced $[Ca^{2+}]i$ increase was suppressed both in a calcium free solution and after depletion of the intracellular $Ca^{2+}$ pool by thapsigargin. Additionally, this increase was predominantly blocked by pretreatment with the transient receptor potential (TRP) antagonists, ruthenium red ($50\;{\mu}M$) and capsazepine ($10\;{\mu}M$). Collectively, these results suggest that an increase in the intracellular calcium concentration is produced from both extracellular fluid and the intracellular calcium store, and that TRP might be involved in the sensation of pain induced by ROS.

• Journal of Radiation Protection and Research
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• 제32권4호
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• pp.190-193
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• 2007

The objective of this study is to recommend the radiation protection design parameters from the shielding point of view for concrete wall between the decay tank room and the primary pump room in TRIGA Mark-II Research Reactor Facility. The shield design for this concrete wall has been performed with the help of Point-kernel Shielding Code Micro-Shield 5.05 and this design was also validated based on the measured dose rate values with Radiation Survey Meter (G-M Counter) considering the ICRP-60 (1990) recommendations for occupational dose rate limit ($10{\mu}Sv/hr$). The recommended shield design parameters are: (i) thickness of 114.3 cm Ilmenite-Magnetite Concrete (IMC) or 129.54 cm Ordinary Reinforced Concrete (ORC) for concrete wall A (ii) thickness of 66.04 cm Ilmenite-Magnetite Concrete (IMC) or 78.74 cm Ordinary Reinforced Concrete (ORC) for concrete wall B and (iii) door thickness of 3.175 cm Mild Steel (MS) on the entrance of decay tank room. In shielding efficiency analysis, the use of I-M concrete in the design of this concrete wall shows that it reduced the dose rate by a factor of at least 3.52 times approximately compared to ordinary reinforced concrete.

• 한국항만경제학회지
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• 제24권2호
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• pp.113-129
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• 2008

항만과 항만관련 산업은 지역경제에 직접, 간접으로 영향을 미친다. 부산의 경우 지역 투입산출표(I-O)를 이용하여 추계하면 항만과 항만관련산업은 지역생산과 부가가치의 최소 1/5이상, 지역고용의 1/7이상의 영향력을 가지는 것으로 나타난다. 항만과 항만관련산업은 부산경제에서 가장 중요한 부문이며 세계의 다른 주요항만인 로테르담이나 싱가포르도 마찬가지이다. 항만이 지역경제에 미치는 영향은 과거 조사에는 실제 조사방법을 사용하였다. 지역투입산출표가 지역경제변수에 대한 보다 다양한 분석을 가능하게 하며 이 논문에서의 몇 개의 응용예가 보고되고 있다.

• 한국환경보건학회지
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• 제28권2호
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• pp.23-39
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• 2002

This study focuses on the structure of geographical conditions, the riverbed, the meterological and atmospheric examination, the ecological environment, the food chain and the ecosystem, in order to establish a basic plan for preparing a natural learning area of environmental ecosystem in Bukchun and its surroundings, Gyeongju. The results could be summarized as follows. Bukchun is a first grade which extends 6km along the road from Bomun bridge to the junction of Hyungsangang. The basin area is 7.10$\textrm{km}^2$ and the slope is 1/200~1/300. Gyeongju has good atmospheric conditions, i.e. SO$_2$0.011 ~0.017ppm, CO 0.8~ 1.5ppm, NO$_2$0.013~0.019ppm, $O_3$0.013~0.020ppm, TSP 85~142$\mu\textrm{g}$/㎥, PM-10 47~90$\mu\textrm{g}$/㎥ and Pb 0.057 ~0.129$\mu\textrm{g}$/㎥, which is below the annual and daily averages, and is little lower than those of Pohang and Ulsan. The ecosystem of Bukchun is based on the structure of the food chain, which includes birds such as the grey and white herons at the top of the food chain. This study also considers the development of the river's in terms of culture, environment and ecology concept.

• 한국컴퓨터정보학회논문지
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• 제11권1호
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• pp.129-138
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• 2006

지금까지 maximal covering문제를 해결하기 위해 다양한 기법들이 적용되어 왔다. 타부 탐색 역시 그 중의 하나이다. 그러나 기존 연구에서는 타부 탐색을 비롯한 언덕오르기 탐색이나 시뮬레이티드 어닐링과 같은 이웃해 탐색 기법들에 대한 종합적인 분석과 성능 향상을 위한 노력이 부족하였다. 본 논문에서는 다양한 실험과 분석을 통해 이웃해 탐색 기법들의 성능을 향상시키기 위한 방안을 소개한다. 기본적으로 모든 이웃해 탐색 기법들은 k-exchange 이웃해 생성 방법을 사용하고 있으며 다양한 파라미터 설정에 따라 각 기법의 성능이 어떻게 달라지는가를 분석하였다. 실험 결과 단순 언덕오르기 탐색과 시뮬레이티드 어닐링이 다른 기법들에 비해 훨씬 우수한 탐색 성능을 보였으며, 일반적인 경우와는 달리 단순 언덕오르기 탐색이 시뮬레이티드 어닐링과 비슷한 성능을 보임을 확인하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제13권2호
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• pp.123-129
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• 2009

Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear. We examined our hypothesis whether inhibitory effects of aprotinin on cytokine-induced inducible nitric oxide synthase (iNOS) expression (IL-$l\beta$ plus TNF-$\alpha$), reactive oxygen species (ROS) generation, and vascular smooth muscle cell (VSMC) proliferation were due to HO-l induction in rat VSMCs. Aprotinin induced HO-l protein expression in a dose-dependent manner, which was potentiated during inflammatory condition. Aprotinin reduced cytokine mixture (CM)-induced iNOS expression in a dose dependent manner. Furthermore, aprotinin reduced CM-induced ROS generation, cell proliferation, and phosphorylation of JNK but not of P38 and ERK1/2 kinases. Aprotinin effects were reversed by pre-treatment with the HO-l inhibitor, tin protoporphyrin IX (SnPPIX). HO-l is therefore closely involved in inflammatory-stimulated VSMC proliferation through the regulation of ROS generation and JNK phosphorylation. Our results suggest a new molecular basis for aprotinin anti-inflammatory properties.

• Nuclear Engineering and Technology
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• 제56권7호
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• pp.2732-2739
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• 2024

This study developed internal dose coefficients for radioiodine, tailored to the Korean population, by incorporating the Korean biokinetic model along with the Korean S values. The observed differences in dose coefficients for Koreans compared to the International Commission on Radiological Protection (ICRP) reference values noticeably varied depending on physical half-lives of iodine isotopes. For longer-lived isotopes such as I-125 and I-129, significant differences in thyroid dose coefficients were observed, with ratios (Korean/ICRP) from 0.30 to 0.55, indicating that actual doses for Koreans can be considerably lower than those evaluated based on the ICRP data. However, for short-lived iodine isotopes, such as I-131, the thyroid dose coefficients were comparable to the ICRP reference values (ratio = 0.95-0.98). These comparable dose coefficients resulted from the lower thyroidal iodine uptake in the Korean model being almost entirely offset by the higher thyroid self-absorption S values in the Korean phantoms. Additionally, this study delves into the substantial differences in absorbed dose coefficients for non-thyroidal regions and effective dose coefficients, which arose not only from physiological/anatomical variability but also technical differences in phantom design. The use of Korean-specific dose coefficients is advisable particularly in scenarios predicting elevated doses, yielding a more precise and clinically relevant dose assessment.

• The Korean Journal of Physiology and Pharmacology
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• 제15권3호
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• pp.129-135
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• 2011

In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigated using a whole-cell patch-clamp technique, intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) analysis, and RT-PCR in ICC. Exogenously-treated 5-HT showed tonic inward currents on pacemaker currents in ICC under the voltage-clamp mode in a dose-dependent manner. Based on RT-PCR results, we found the existence of 5-$HT_{2B,\;3,\;4,\;and\;7}$ receptors in ICC. However, SDZ 205557 (a 5-$HT_4$ receptor antagonist), SB 269970 (a 5-$HT_7$ receptor antagonist), 3-tropanylindole - 3 - carboxylate methiodide (3-TCM; a 5-$HT_3$ antagonist) blocked the 5-HT-induced action on pacemaker activity, but not SB 204741 (a 5-$HT_{2B}$ receptor antagonist). Based on $[Ca^{2+}]_i$ analysis, we found that 5-HT increased the intensity of $[Ca^{2+}]_i$. The treatment of PD 98059 or JNK II inhibitor blocked the 5-HT-induced action on pacemaker activity of ICC, but not SB 203580. In summary, these results suggest that 5-HT can modulate pacemaker activity through 5-$HT_{3,\;4,\;and\;7}$ receptors via $[Ca^{2+}]_i$ mobilization and regulation of mitogen-activated protein kinases.

• 무역학회지
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• 제48권2호
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• pp.129-151
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• 2023

본 연구는 국내 주요 수입 수산물- 냉동명태, 냉동고등어, 냉동참치 그리고 냉동어란- 시장을 대상으로, 각 수출국이 차지하는 시장점유율에 따라, FTA 발효가 환율전가도에 미친 영향이 어떻게 달라지는 지 살펴 보았다. 이에 더하여 각 수출국이 차지하는 시장점유율이 원화표시 수출가격 환율전가도에 미친 영향 뿐만 아니라, 수출국들의 가격경쟁구조에 미친 영향 역시 살펴보았다. 이를 위해, 본 연구는 2010년 1월부터 2019년 12월까지 각 수출국의 원화표시 수산물 수출가격과 각 수산물 수입시장에서 개별 수출국별 교차환율의 월별 자료를 이용하여, 최대우도법(Maximum Likelihood)을 바탕으로, 각 수출국의 원화표시 수출가격함수를 추정하였다. 분석 결과, FTA 발효가 환율전가도에 미친 영향은 수출국인 FTA 회원국이 차지하는 시장점유율과 높은 상관관계에 있음을 발견하였다. 하지만 수출국이 차지하는 시장점유율과 원화표시 수출가격 환율전가도 그리고 다른 경쟁국의 수출가격에 미친 영향 사이에서는 뚜렷한 관계를 파악하기 어려웠다. 본 연구 결과를 통해, 국내 수산업자들은 국내 주요 수산물 수입시장에서 각 수출국들이 차지하는 시장점유율에 따른 환율전가도 차이 및 FTA 발효가 환율전가도에 미친 영향의 차이 그리고 수출국들 사이의 가격경쟁구조를 이해하는 데 중요한 자료가 될 것이라 예상된다. 뿐만 아니라, 각 수산물 수입시장에서 차지하는 시장점유율에 따라, 각 수출국별로 FTA 발효 이후, 환율이 국내 수산업에 미치는 영향에 대응할 수 있는 방안에 관해 생각해 보는 데 도움이 될 것이라 사료된다.