• Title/Summary/Keyword: $^{11}C$ Beam

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Dose Distribution of $^{11}C$ Beams for Spot Scanning Radiotherapy

  • Urakabe, Eriko;Kanai, Tatsuaki;Kanazawa, Mitsutaka;Kitagawa, Atsushi;Noda, Koji;Tomitani, Takehiro;Suda, Mitsuru;Mizuno, Hideyuki;Iseki, Yasushi
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.202-205
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    • 2002
  • This paper describes the spot scanning with $^{11}$ C beams for the Heavy Ion Medical Accelerator in Chiba (HIMAC). The concave-shaped irradiation field was optimized and the dose distribution was measured by 128-ch ionization chamber. Because of the wide momentum spread inherent in $^{11}$ C beams, the dispersion caused from the beam line and the scanning magnets should be taken into account to calculate the dose distribution of $^{11}$ C beams and their irradiated field. The reconstructed dose distribution is in good agreement with the experimental results.

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Production of $^{11}C$ labeled Radiopharmaceuticals using $[^{11}C]CO_2$ Produced in the KOTRON-13 (한국형 사이클로트론(KOTRON-13)을 이용한 $[^{11}C]CO_2$ 생산과 다양한 $^{11}C$-표지 방사성의약품 생산 적용)

  • Lee, Hong Jin;Park, Jun Hyung;Moon, Byung Seok;Lee, In Won;Lee, Byung Chul;Kim, Sang Eun
    • The Korean Journal of Nuclear Medicine Technology
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    • v.16 no.2
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    • pp.106-109
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    • 2012
  • Purpose : The KOTRON-13 cyclotron was developed and installed in regional cyclotron centers to produce short-lifetime medical radioisotopes. However, this cyclotron has limited capacity to produce $^{11}C$ so far. In present study, we developed an effective $^{11}C$ target system combining with fluorine-18 target and applied to the production of various $^{11}C$ radiopharmaceuticals. Materials and Methods : To develop the optimal $^{11}C$ target system and effective its cooling system, we designed the $^{11}C$ target system by Stopping and Range of Ions in Matter (SRIM) simulation program and considered the cavity pressure during irradiation at target grid. In this investigation, we modified target materials, cavity shapes and the position of cooling system in $^{11}C$ target and then evaluated $[^{11}C]CO_2$ production at different beam currents, thickness of the target foil, oxygen content of nitrogen gas and target gas loading pressure. Also, we evaluate the production of several $^{11}C$ radiopharmaceuticals such as [$^{11}C$]PIB, [$^{11}C$]DASB, and [$^{11}C$]Clozapine. Results : $[^{11}C]CO_2$ was produced about 74 GBq for 30min irradiation at 60 ${\mu}A$ of beam current as following conditions: thickness of the target foil: 19 nm HAVAR, oxygen content of nitrogen: under 50 ppb, target gas loading pressure: 24 bar. Additionally, the cooling system was stable to produce $[^{11}C]CO_2$ at high beam current. The radiochemical yields of [$^{11}C$]PIB, [$^{11}C$]DASB, and [$^{11}C$]Clozapine showed about 26-38% with over 127 GBq/umol of specific activity. Conclusion : The carbon-11 target system in the KOTRON-13 cyclotron was successfully developed and showed stable production of $[^{11}C]CO_2$. These results showed that our $^{11}C$ target system will be compatible with other commercial system for the routine $^{11}C$ radiopharmaceuticals production in the KOTRON-13 cyclotron.

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Comparative study of finite element analysis and generalized beam theory in prediction of lateral torsional buckling

  • Sharma, Shashi Kant;Kumar, K.V. Praveen;Akbar, M. Abdul;Rambabu, Dadi
    • Advances in materials Research
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    • v.11 no.1
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    • pp.59-73
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    • 2022
  • In the construction industry, thin-walled frame elements with very slender open cross-sections and low torsional stiffness are often subjected to a complex loading condition where axial, bending, shear and torsional stresses are present simultaneously. Hence, these often fail in instability even before the yield capacity is reached. One of the most common instability conditions associated with thin-walled structures is Lateral Torsional Buckling (LTB). In this study, a first order Generalized Beam Theory (GBT) formulation and numerical analysis of cold-formed steel lipped channel beams (C80×40×10×1, C90×40×10×1, C100×40×10×1, C80×40×10×1.6, C90×40×10×1.6 and C100×40×10×1.6) subjected to uniform moment is carried out to predict pure Lateral Torsional Buckling (LTB). These results are compared with the Finite Element Analysis of the beams modelled with shell elements using ABAQUS and analytical results based on Euler's buckling formula. The mode wise deformed shape and modal participation factors are obtained for comparison of the responses along with the effect of varying the length of the beam from 2.5 m to 10 m. The deformed shapes of the beam for different modes and GBTUL plots are analyzed for comparative conclusions.

Change of Sprouting-related Enzymes Activities and Food Quality Characteristics of Sweetpotato Root (Ipomea batatas Lam.) by Electron Beam Irradiation (전자빔 조사에 의한 고구마의 발아관련 효소의 활성과 식품특성 변화)

  • Lim, Sung Jin;Song, Mi Seon;Lee, Gyeong Ae;Cho, Jae-Young
    • Journal of Applied Biological Chemistry
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    • v.55 no.4
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    • pp.267-272
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    • 2012
  • We investigated that electron beam irradiation is the effective method to control the sprouting of sweetpotato roots without changing of food quality characteristics. In 12 and $25^{\circ}C$ storage after electron beam irradiation, all control samples were sprouted from 6 and 4 weeks after storage, respectively. The sprouting rate of control increased with time and the rate reached to 11.2-12.4 and 70.5-74.2% at 8 weeks after 12 and $25^{\circ}C$ storage. Also, the sprouting of middle and below positioning sweetpotato roots at 12 and $25^{\circ}C$ storage after irradiation reached to 8.6-11.3 and 42.7-48.7% after a storage period of 8 weeks, respectively. However, the sprouting of all sweetpotato roots stored at $4^{\circ}C$ and upper (0-7 cm) positioning samples of box stored at 12 and $25^{\circ}C$ with electron beam was completely inhibited due to increase peroxidase and indole acetic acid (IAA) oxidase activity. Also, all samples with electron beam such as hardness, pH, sugar content, weight loss, and vitamin C and dacarotene content did not differ from that of the control. Therefore, if electron beam will be irradiated to sweetpotato roots above 0.1 kGy before packing, it will effectively inhibit their sprouting stored at $25^{\circ}C$ without the change of food quality characteristics.

Estimation of Nuclear Interaction for $^{11}C$ Cancer Therapy

  • Maruyama, Koichi;Kanazawa, Mitsutaka;Kitagawa, Atsushi;Suda, Mitsuru;Mizuno, Hideyuki;Iseki, Yasushi
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.199-201
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    • 2002
  • Cancer therapy using high-energy $^{12}$ C ions is successfully under way at HIMAC, Japan. An alternative beam to $^{12}$ C is $^{11}$ C ions. The merit of $^{11}$ C over $^{12}$ C is its capability for monitoring spatial distribution of the irradiated $^{11}$ C by observing the $\beta$$^{+}$ decay with a good position resolution. One of the several problems to be solved before its use for therapy is the amount of nuclear interaction that deteriorates the dose concentration owing to the Bragg curve. Utilizing the dedicated secondary beam course for R&D studies at HIMAC, we measured the total energy loss of $^{11}$ C ions in a scintillator block that simulates the soft tissue in human bodies. In addition to the total absorption $^{11}$ C peak, non-negligible bump-shaped contribution is observed in the energy spectrum. The origin of the bump contribution can be nuclear interaction of the incident $^{11}$ C ions with hydrogen and carbon atoms. Further studies to reduce the ambiguity in dose distribution are mentioned.

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Novel techniques for improving the interpolation functions of Euler-Bernoulli beam

  • Chekab, Alireza A.;Sani, Ahmad A.
    • Structural Engineering and Mechanics
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    • v.63 no.1
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    • pp.11-21
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    • 2017
  • In this paper, the efficiency and the accuracy of classical (CE) and high order (HE) beam element are improved by introducing two novel techniques. The first proposed element (FPE) provides an alternative for (HE) by taking the mode shapes of the clamped-clamped (C-C) beam into account. The second proposed element (SPE) which could be utilized instead of (CE) and (HE) considers not only the mode shapes of the (C-C) beam but also some virtual nodes. It is numerically proven that the eigenvalue problem and the frequency response function for Euler-Bernoulli beam are obtained more accurate and efficient in contrast to the traditional ones.

Effects of Combined Treatment of Aqueous Chlorine Dioxide and UV-C or Electron Beam Irradiation on Microbial Growth and Quality in Chicon during Storage (이산화염소수와 UV-C 또는 전자빔 병합처리가 치콘의 저장 중 미생물 성장과 품질에 미치는 영향)

  • Kang, Ji Hoon;Park, Jiyong;Oh, Deog Hwan;Song, Kyung Bin
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.11
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    • pp.1632-1638
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    • 2012
  • The effects of combined treatment of aqueous $ClO_2$ and UV-C or electron beam irradiation on microbial growth and quality in chicon during storage at $4^{\circ}C$ were investigated. Samples were treated separately with 50 ppm of $ClO_2$, 5 kJ/$m^2$ of UV-C, 2, 5, 7, and 10 kGy of electron beam irradiation, as well as a combination of $ClO_2$ and UV-C or 2 kGy of electron beam irradiation. The populations of total aerobic bacteria as well as yeast and molds in the chicon samples were determined following each treatment. The populations of total aerobic bacteria in the chicon samples decreased by 1.49~2.92 log CFU/g following combined treatment of $ClO_2$ and UV-C irradiation compared to the control, whereas the populations of yeast and molds decreased by 1.63~1.78 log CFU/g. On the contrary, following combined treatment of $ClO_2$ and electron beam irradiation, the populations of total aerobic bacteria as well as yeast and molds in the chicon samples were undetectable during storage. Color measurements indicated that Hunter $L^*$, $a^*$, and $b^*$ values were not significantly different among the treatments during storage. These results suggest that combined treatment of $ClO_2$ and electron beam irradiation can be useful for improving microbiological safety in chicon during storage.

A Convergent Study on the Structural Analysis of Automotive Support Beam (자동차 서포트빔의 구조해석에 대한 융합 연구)

  • Choi, Kye-Kwang;Cho, Jae-Ung
    • Journal of the Korea Convergence Society
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    • v.11 no.9
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    • pp.169-173
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    • 2020
  • The structural analysis was performed at this study when the axle was loaded by using a total of three automotive support beam models, models A, B and C. Comparing with three models A, B, and C, the equivalent stress is considered to be good for its durability because model C is less than the yield stress of the material. The maximum equivalent stresses happening at models A and B are 1.8 times and 2.5 times higher than the yield stress, respectively, indicating that the material is fractured. So, it does not seem to be efficient as a support beam. Model C can be applied efficiently to the improvement design of axle support beams in terms of durability compared to models A and B. The strength of automotive support beam can be evaluated by applying this research result to the automotive part. And it is seen that this study is adequate at the efficient design and aesthetic convergence practically.

Monte Carlo Calculation for Production Cross-Sections of Projectile's Isotopes from Therapeutic Carbon and Helium Ion Beams in Different Materials

  • Quazi Muhammad Rashed Nizam;Asif Ahmed;Iftekhar Ahmed
    • Journal of Radiation Protection and Research
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    • v.48 no.4
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    • pp.204-212
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    • 2023
  • Background: Isotopes of the projectile may be produced along the beam path during the irradiation of a target by a heavy ion due to inelastic interactions with the media. This study analyzed the production cross-section of carbon (C) and Helium (He) projectile's isotopes resulting from the interactions of these beams with different materials along the beam path. Materials and Methods: In this study, we transport C and He ion beams through different materials. This transportation was made by the Monte Carlo simulation. Particle and Heavy Ion Transport code System (PHITS) has been used for this calculation. Results and Discussion: It has been found that 10C, 11C, and 13C from the 12C ion beam and 3He from the 4He ion beam are significant projectile's isotopes that have higher flux than other isotopes of these projectiles. The 4He ion beam has a higher projectile's isotope production cross-section along the beam path, which adds more impurities to the beam than the 12C ion beam. These projectile's isotopes from both the 12C and 4He ion beams have higher production cross-sections in hydrogenous materials like water or polyethylene. Conclusion: It is important to distinguish these projectile's isotopes from the primary beam particles to obtain a precise and accurate cross-section result by minimizing the error during measurement with a nuclear track detector. This study will show the trend of the production probability of projectile's isotopes for these ion beams.

LC Alignment Effects using a-C:H Thin Film as Working Gas at Bias Condition (바이어스 조건하에서 증착한 a-C:H 박막을 이용한 액정배향 효과)

  • 황정연;조용민;서대식;노순준;백홍구
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.16 no.11
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    • pp.1019-1022
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    • 2003
  • We studied the nematic liquid crystal (NLC) aligning capabilities using the new alignment material of a-C:H thin film as working gas at 30W rf bias condition. A high pretilt angle of about 5$^{\circ}$ by ion beam(IB) exposure on the a-C:H thin film surface was measured. A good LC alignment by the IB alignment method on the a-C:H thin film surface was observed at annealing temperature of 250$^{\circ}C$, and the alignment defect of the NLC was observed above annealing temperature of 300$^{\circ}C$. Consequently, the high LC pretilt angle and the good thermal stability of LC alignment by the IB alignment method on the a-C:H thin film surface as working gas at 30W rf bias condition can be achieved.