• 대한의생명과학회지
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• 제19권2호
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• pp.147-152
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• 2013

17-${\beta}$-hydroxysteroid dehydrogenase type 1 ($17{\beta}$-HSD type 1) mediates the reaction of $17{\beta}$-estradiol (E2) production from estrone (E1). Inhibitory effects of curcuminoids on $17{\beta}$-HSD type 1 activity were investigated to find a lead compound for treating estrogen-dependent diseases including breast cancer. Among curcuminoids, demethoxycurcumin showed potent inhibitory effect ($IC_{50}=2.7{\mu}M$) on mouse $17{\beta}$-HSD type 1. Curcuminoids also displayed their inhibitory effects on the production of $17{\alpha}$-estradiol which is a carcinogenic metabolite produced by the enzyme. Bisdemethoxycurcumin ($IC_{50}=1.3{\mu}M$) showed potent inhibitory effect on the $17{\alpha}$-estradiol production by chicken $17{\beta}$-HSD type 1. Curcuminoids did not inhibit ERE transcriptional activity with and without E2. Taken together, curcuminoids can be used for treating and preventing E2-dependent diseases via inhibition on $17{\beta}$-HSD type 1 activity.

• Preventive Nutrition and Food Science
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• 제9권1호
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• pp.71-78
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• 2004

Adrenergic receptors play a major role in thermogenesis and lipolysis in brown and visceral adipose tissues, and have been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of $\beta$2-adrenergic receptor ($\beta$2AR) and $\beta$3-adrenergic receptor ($\beta$3AR) genotypes on hyperglycemia and obesity in the Korean population. A representative sample consisting of 530 Korean men and women were measured for height, weight, BMI, WHR, obesity index and body composition. The genotypes of $\beta$2AR polymorphism in codon 27 and $\beta$3AR polymorphism in codon 64 were analyzed by the PCR RFLP method. Serum concentrations of fasting glucose, total cholesterol, HDL cholesterol and triglyceride were determined. The frequencies of $\beta$2AR and $\beta$3AR genotype were: both wild type, 62.5% ; only $\beta$2AR variant type, 12.8% ; only $\beta$3AR variant type, 18.8% ; and both variant type, 5.8% ; the frequency of E and R alleles were 0.098 and 0.137, respectively. Among the physiological parameters, fasting glucose level was significantly higher in subjects with both variant type compared with the three other types (p <0.05), Subjects with both variant type had 12%, 12% and 9.3% increases in serum glucose levels compared with wild type, only $\beta$2AR variant type, and only $\beta$3AR variant type, respectively. When logistic regression analysis was conducted to estimate the risk for hyperglycemia, the subjects were selected for fasting blood glucose concentrations of more than 6.105 m㏖/L (110 mg/dL), and the odds ratios were 1.215 (p=0.636) for only $\beta$2AR variant type,1.659 (p=0.089) for only $\beta$3AR variant type, and 3.078 (p=0.011) for both variant type. These results suggest that the interaction of $\beta$2AR and $\beta$3AR variant genotypes has a strong association with increased glucose levels, and might be a significant risk factor for hyperglycemia among Korean subjects.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.69-69
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• 2003

Although effect of TGF$\beta$$_1$ on preimplantation embryo development was reported at mice, little information relevant to this subject is known in bovine. The objectives of this study were to investigate TGF$\beta$$_1$, and TGF$\beta$$_1$ receptors type I and II expression, known as important factors in the embryo development, at unfertilized oocytes and fertilized embryos that will be used as basic data to be compared to NT embryos. We postulated that TGF$\beta$$_1$ may have a beneficial effect on the preimplantation embryo and show different expression patterns as embryo stages change. We have used immunocytochemistry to investigate the presence in unfertilized oocytes and preimplantation embryos of TGF$\beta$$_1$ and the essential components of the TGF$\beta$$_1$ signalling pathway, TGF$\beta$$_1$ receptors type I and II. We found that both receptors, as well as TGF$\beta$$_1$, were present in the unfertilized oocytes. This indicates that TGF$\beta$$_1$, is a maternally expressed protein. At the morulae and blastocyst stages the TGF$\beta$$_1$ receptor type II was not present, but the TGF$\beta$$_1$ receptor type I was present at both stages and we can confirm the TGF$\beta$$_1$ expression of high level at 8-cell stage. These findings support our hypothesis that the TGF$\beta$$_1$, and TGF$\beta$$_1$ receptors may interact with the oocyte and preimplantation embryo, and that TGF$\beta$$_1$ signalling may be important for the development of the oocyte and the preimplahtation embryo.

• 대한치과기공학회지
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• 제27권1호
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• pp.9-17
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• 2005

The use of titanium alloys as biomaterials is increasing due to their superior biocompatibility and enhanced corrosion resistance compared to conventional stainless steels and cobalt-based alloys. Ti-6Al-4V ($\alpha+\beta$type) alloy instead of pure titanium ($\alpha$type) is being widely used as biomaterials has some characteristics such as high fatigue strength, tensile strength and corrosion resistance. But it has been reported recently that the vanadium element expresses cytotoxicity and the aluminium element is related with dementia of Alzheimer type and neurotoxicity. In order to overcome their detrimental effects, $\beta$-phase stabilizer Nb was chosen in the present study. This paper was described the influence of phase changes of Ti-Nb alloys on mechanical properties. Ti-3wt.%Nb($\alpha$type),Ti-20wt.%Nb($\alpha+\beta$type) and Ti-40wt.%Nb($\beta$type) alloys were melted by vacuum arc furnace. The specimens were homogenized at 1050$^{\circ}C$ for 24hr and were then hot rolled to 50% reduction. Each alloys were solution heat treated at $\beta$ zone and $\alpha+\beta$ zone after homogenization and then were aged. The mechanical properties of Ti alloys were analysed by hardness test, tensile test, elongation test and SEM test. The results can be summarized as follows: 1) The higher hardness value of $\alpha+\beta$type alloy was obtained compared to the, $\alpha,\beta$type alloys. 2) The aged treated showed better hardness compared to the solution heat treated, homogenized. 3) In the case of solution and aging treatment at $\beta$region, the $\alpha+\beta$type alloy showed the most highest tensile strength and $\beta$type alloy showed the best elongation.

• 제어로봇시스템학회논문지
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• 제5권6호
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• pp.744-752
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• 1999

In this paper, we studied the response characteristics of $\alpha$, $\beta$ separated type, combined type, PI typed, and feedforward type in 2DOF-PID controller through the simulation and the experiments designed with the multivariable flow control system. The parameters $\alpha$ and $\beta$ give an affect to characteristics of controller in separated type but $\gamma$ does not give an affect to the characteristics of 2-DOF PID. The more $\beta$ increases, the more overshoot decreases and especially, in case of PI type represent clearly. The $\alpha$, $\beta$ separated type has a very small overshoot and its magnitudes in 2-DOF PID onctroller increases in order of $\alpha$, $\beta$ combined type, PI type, feedforward type, conventional type. The response characteristics of simulation are similar to that of experiments but the experimental characteristics in the multivariable flow control system has the delayed response. The time delay of response in experiments depends on 2-DOF parameter $\alpha$, $\beta$, $\gamma$ and the overshoot increase as the $\alpha$, $\beta$, $\gamma$ increase. So, we can have a satisfactory response by tuning D gain.

• 대한수학회보
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• 제56권5호
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• pp.1117-1127
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• 2019

Let ${\mathcal{L}}_2=(-{\Delta})^2+V^2$ be the $Schr{\ddot{o}}dinger$ type operator, where nonnegative potential V belongs to the reverse $H{\ddot{o}}lder$ class $RH_s$, s > n/2. In this paper, we consider the operator $T_{{\alpha},{\beta}}=V^{2{\alpha}}{\mathcal{L}}^{-{\beta}}_2$ and its conjugate $T^*_{{\alpha},{\beta}}$, where $0<{\alpha}{\leq}{\beta}{\leq}1$. We establish the $(L^p,\;L^q)$-boundedness of operator $T_{{\alpha},{\beta}}$ and $T^*_{{\alpha},{\beta}}$, respectively, we also show that $T_{{\alpha},{\beta}}$ is bounded from Hardy type space $H^1_{L_2}({\mathbb{R}}^n)$ into $L^{p_2}({\mathbb{R}}^n)$ and $T^*_{{\alpha},{\beta}}$ is bounded from $L^{p_1}({\mathbb{R}}^n)$ into BMO type space $BMO_{{\mathcal{L}}1}({\mathbb{R}}^n)$, where $p_1={\frac{n}{4({\beta}-{\alpha})}}$, $p_2={\frac{n}{n-4({\beta}-{\alpha})}}$.

• 한국조리학회지
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• 제22권7호
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• pp.148-157
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• 2016

본 연구에서는 디저트 카페를 소비자의 식생활 라이프스타일에 따른 창업자들의 디저트카페의 품질 특성이 소비자의 소비행동에 미치는 영향을 검증하였고, 디저트 카페를 방문하는 218명의 고객을 대상으로 2016년 4월 15일부터 15일간 실시하였다. 연구의 결과를 요약하면 다음과 같다. 첫째, 식생활 라이프 스타일에 따라 디저트 카페의 서비스 품질에 미치는 영향을 검증하기 위해 식생활 라이프스타일의 하위변수인 미각추구형, 편의추구형, 건강추구형으로 3가지를 변수로 설정하였고, 종속변수인 서비스 품질은 신뢰성과 공감성으로 2가지 변수로 설정하고 회귀분석으로 실시한 결과, 먼저 종속변수인 신뢰성에 대한 회귀분석의 결과는 식생활 라이프스타일의 3개의 하위변수인 미각추구형(${\beta}=.371$, p<.001), 편의추구형(${\beta}=.401$, p<.001), 건강추구형(${\beta}=.474$, p<.001)으로 서비스 품질의 신뢰성에 대하여 모두 유의한 정(+)의 영향관계가 있는 것으로 분석되었다. 또한 서비스 품질의 공감성에 대한 회귀분석결과, 미각 추구형(${\beta}=.145$, p<.001), 편의추구형(${\beta}=.208$, p<.001), 건강추구형(${\beta}=.236$, p<.001)으로 모두 유의한 정(+)의 영향관계가 있는 것으로 분석되었다. 둘째, 디저트 카페의 서비스 품질이 소비자의 소비행동에 미치는 영향을 검증한 결과, 디저트 카페의 서비스 품질의 하위변수인 신뢰성과 공감성으로 2가지의 변수로 설정하고, 종속변수인 소비행동에 대한 회귀분석 결과 투입된 2개의 독립변수 중에서 신뢰성(${\beta}=.313$, p<.001), 공감성(${\beta}=.228$, p<.001)으로 소비행동에서 신뢰성과 공감성에 대하여 모두 유의한 정(+)의 영향관계가 있는 것으로 분석되었다.

• 약학회지
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• 제39권3호
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• pp.276-282
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• 1995

Compared to the first and second-generation cephalosporins, the third-generation cephalosporins are remarkably stable against hydrolysis by the $\beta$-lactamases produced by aerobic gram-negative bacilli, such as Enterobacteriaceae. Among these bacteria, the most prevalent plasmid-encoded $\beta$-lactamase is TEM-1 $\beta$-lactamase belonging to class A or group 2b. This enzyme is produced constitutively and is principally active against peniciflins and old cephalosporins rather than third-generafion cephalosporins, carbapenems and mmobactams. However, new TEM type $\beta$-lactamases including TEM-9 and TEM-12 evolved through point mutations in a gene encoding $\beta$-lactamase have been discovered from patients during chemotherapy. These $\beta$-lactamases are known to be capable of hydrolyzing most of the third-generatim cephalosporins. To study the prevalence of $\beta$-lactamases from clinical isolates collected in Korea. the minimal inhibitory concentratims(MICs) of several third-generation cephalosporins against 628 clinical isolates were determined by agar dilution methods, and $\beta$-lactamas-producing bacteria were isolated by use of cefinase disc. By polymerase chain reaction (PCR) method, clinical isolates harboring a gene for TEM type $\beta$-lactamase were identified among the $\beta$-lactamase producing strains. Twentiy three percent of the clinical isolates was resistant to the thirdgeneration cephalosporins, and more than 90% of resistant cells produced various $\beta$-lactamases. TFM type $\beta$-lactamases were dominant in gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, Enterobacter species. These results suggest the necessity of the development of new cephalosporins which are stable against $\beta$-lactamases like TEM.

• 호남수학학술지
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• 제46권2호
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• pp.313-334
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• 2024

In the current study, our aim is to define new generalized extended beta and hypergeometric types of functions. Next, we methodically determine several integral representations, Mellin transforms, summation formulas, and recurrence relations. Moreover, we provide log-convexity, Turán type inequality for the generalized extended beta function and differentiation formulas, transformation formulas, differential and difference relations for the generalized extended hypergeometric type functions. Also, we additionally suggest a generating function. Further, we provide the generalized extended beta distribution by making use of the generalized extended beta function as an application to statistics and obtaining variance, coefficient of variation, moment generating function, characteristic function, cumulative distribution function, and cumulative distribution function's complement.

• 한국간호교육학회지
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• 제22권2호
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• pp.210-219
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• 2016

Purpose: The purpose of this study was to contribute to career counseling and career guidance for nursing students by examining students' career decision-making styles and career decision levels and the relationship between self-efficacy and career decision-making styles and career decision levels. Methods: A descriptive survey design was used and data were collected using questionnaires from a sample of 469 nursing students. The data were analyzed using frequencies means, Kruskal-Wallis test, Pearson correlation coefficient, and multiple regression analysis with SPSS 21.0. Results: Career decision level had a significant correlation with self-efficacy and decision-making styles. Self-efficacy (${\beta}=.143$, p<.001), type of decision-making styles rational type (${\beta}=.180$, p<.001), intuitive type (${\beta}=.137$, p<.001), dependent type (${\beta}=-.236$, p<.001) and sex (${\beta}=-.086$, p=.023), school grades (${\beta}=.086$, p=.033), and satisfaction of nursing major (${\beta}=.209$, p<.001) were significant predictors of career decision level. Conclusion: It is necessary to develop effective career support programs according to type of decision-making styles, sex, school grades, motivation to improve nursing students' self-efficacy and satisfaction in the nursing major.