• Korean Journal of Culture and Social Issue
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• v.12 no.5_spc
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• pp.29-43
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• 2006

With longevity (75 years plus and still increasing) now commonly achievable, the new challenge for individuals and society is less concerned with adding more years to life, though that remains important, and more with adding life to years. To explore the quality of long life more fully, a concept broader than healthy ageing or active ageing is needed. For this purpose, the present article describes a framework of Positive Ageing, also known as Successful Ageing, which views the quality of long life as comprising good health, physical and cognitive functional independence, and meaningful engagement with life. Narrowly defined, it refers to old people ageing well in all these aspects. More broadly defined, it refers to ageing well from midlife on. The framework also identifiesvariables that may affect the process of ageing positively. These variables include the social-cognitive styles of control, humour and future-time perspective on the one hand, and on the other hand, resources based on finance, social network and lifestyle.

• Journal of the Korean housing association
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• v.26 no.5
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• pp.37-44
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• 2015

The purpose of this study was to compare urban and rural seniors' perceptions on the eight aspects of the World Health Organization Age-Friendly Cities (AFC) initiative on Jeju Island, South Korea. Face-to-face interviews using structured questionnaires were administered to 497 persons aged 65+ living on Jeju Island. Findings suggested that urban and rural held significantly different perceptions on five aspects of AFC (outdoor space and buildings, housing, civic participation and employment, community support and health services, and respect and social inclusion). Predictors of overall AFC score for all participants included age and living in a single-family home. Among urban dwellers, monthly household income and length of residence predicted AFC score while among rural seniors, predictors of AFC included educational attainment. To make communities more age-friendly, perspectives of older residents should be sought, shared, and reflected in policy and different strategies and priorities should be developed specific to urban and rural areas.

• Journal of Korean Home Economics Education Association
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• v.7 no.2
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• pp.67-77
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• 1995

This study aims at seeking the effective career guidance and operational plan. We collected data from questionaries to 305 students of vocational school, and 135 students on vocational course for the recognition of and request for vocational home economics curriculum. Collected data were analysed by frequency, percentage, and X(sup)2, and SPSS/PC(sup)+ program are used for the statistical analysis. 1. The main considerations of students in their decision of course were the accessibility of getting a job, or a higher education aptitude, interest, and so on. They made their own decision in choosing their course, relatively were satisfied with their choices. As for the course after graduation they hoped to come by a job related to their major in order to have3 an opportunity for further education, and teachers stood up for the large extent to which their students are satisfied with vocational training by answering that there would be higher possibility of using their major. 2 The results of the investigation into the desirable home economics vocational training in future showed that students of vocational schools desired for the scientific teaching and learning method. Students on vocational curse requested that the educational system should be supported. And new curricula were those for gerontology. interior design, and cookery and bakery.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.136-140
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• 2000

A sensitive and quantiative method for the structural analysis of oligosaccharide was established for the glycoform analysis of glconproproteins. Inthis study, n-linked oligosaccharides of human IgG and bovine transferin were analyzed for the evaluation of the methydrate moiety ofthe method. Chrbohydrate moiety of glycoprotein was relased by hydrazinolysis and purified by paper chromatography. The oligosaccharides were labeled with a fluorescent bye, 2-aminobenzamide, for the enhancement of detection sensitivity. sialylated (acidic) oligosaccharides were separated from neutral oligosaccharide by employing a strong anion-exchange column(MonoQ) followed by the treatment with sialidase. Enzymatically desiayated fractions and neutral fractions of oligosaccharides were applied to normal-phase HPLC to resolve the peaks according to glucose unit (GU). The structure of separated molecules was further determined by sequential digestion with exoglycosidases. As a result, disialylated biantennary complextype oligosaccharide was found to be a major sugar chain in bovine transferrin (63%). In human IgG, core fucosylated asialobiantennary complex oligosaccharides were dominant. These results coincided well with reported results.

• IMMUNE NETWORK
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• v.14 no.1
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• pp.30-37
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• 2014

Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a pathogen. Here, we show that murine DC produced increased IL-23 and IL-6 when they were treated with LPS together with curdlan that activates TLR4 and dectin-1, respectively. We also found that the induction of the inflammatory cytokine production by LPS and curdlan requires activation of IKK. However, the same treatment did not induce DC to produce a sufficient amount of TGF-${\beta}$. As a result, the conditioned media from DC treated with LPS and curdlan was not able to direct $CD4^+$ T cells to Th17 cells. Addition of TGF-${\beta}$ but not IL-6 or IL-$1{\beta}$ was able to promote IL-17 production from $CD4^+$ T cells. Our results showed that although signaling mediated by LPS together with curdlan is a potent stimulator of DC to secrete many pro-inflammatory cytokines, TGF-${\beta}$ production is a limiting factor for promoting Th17 immunity.

• Journal of Preventive Medicine and Public Health
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• v.46 no.sup1
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• pp.50-54
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• 2013

Out-of-home mobility is necessary for accessing commodities, making use of neighborhood facilities, and participation in meaningful social, cultural, and physical activities. Mobility also promotes healthy aging as it relates to the basic human need of physical movement. Mobility is typically assessed either with standardized performance-based tests or with self-reports of perceived difficulty in carrying out specific mobility tasks. Mobility declines with increasing age, and the most complex and demanding tasks are affected first. Sometimes people cope with declining functional capacity by making changes in their way or frequency of doing these tasks, thus avoiding facing manifest difficulties. From the physiological point of view, walking is an integrated result of the functioning of the musculoskeletal, cardio-respiratory, sensory and neural systems. Studies have shown that interventions aiming to increase muscle strength will also improve mobility. Physical activity counseling, an educational intervention aiming to increase physical activity, may also prevent mobility decline among older people. Sensory deficits, such as poor vision and hearing may increase the risk of mobility decline. Consequently, rehabilitation of sensory functions may prevent falls and decline in mobility. To promote mobility, it is not enough to target only individuals because environmental barriers to mobility may also accelerate mobility decline among older people. Communities need to promote the accessibility of physical environments while also trying to minimize negative or stereotypic attitudes toward the physical activity of older people.

• BMB Reports
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• v.51 no.2
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• pp.79-84
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• 2018

Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency of NPC1 gene function, which leads to severe neuroinflammation such as astrogliosis. While reports demonstrating neuroinflammation are prevalent in NP-C, information about the onset and progression of cerebellar astrogliosis in this disorder is lacking. Using gene targeting, we generated vascular endothelial growth factor (VEGF) conditional null mutant mice. Deletion of VEGF in cerebellar Purkinje neurons (PNs) led to a significant increase of astrogliosis in the brain of NP-C mice in addition to the loss of PNs, suggesting PN-derived VEGF as an important factor in NP-C pathology. Moreover, replenishment of VEGF in neurons improved brain pathology in NP-C mice. Overall, our data provide a new pathological perspective on cerebellar astrogliosis in NP-C and suggest the importance of VEGF as a therapeutic target for this disease.

• Women's Health Nursing
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• v.16 no.1
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• pp.47-59
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• 2010

Purpose: The purpose of this study was to develop a Korean version of Physical Activity Scale for the Elderly (K-PASE) from PASE and to evaluate the validity and reliability of the K-PASE. This scale was originally developed by Washburn et al. (1993). A valid and reliable physical activity scale for the elderly is needed to assess accurately physical activity of the elderly, because there has been no valid and reliable physical activity scale for the elderly in Korea. Methods: The K-PASE was developed from PASE through linguistic validation and cultural adaptation for use with this population. Convenient sampling was used to recruit participants. Reliability was evaluated by conducting the test-retest and convergent validity was evaluated by Pearson correlation. Results: Test-retest reliability, assessed over a 2 week interval, was r=.94. Convergent validity was established by correlating the KPASE scores between related variables which were the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) and hand-grip strength. Scores of the K-PASE had a low significant correlation with TMIG-IC (r=.246, p<.001), and hand-grip strength (r=.251, p<.001). The mean score of physical activity of Korean elderly assessed by the K-PASE was 96.5. Conclusion: We conclude that the K-PASE is a reliable and valid instrument to assess physical activity for Korean elderly.

• 한국노년학
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• v.27 no.2
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• pp.299-322
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• 2007

The purpose of this study is to critically review recent discourse on aging appeared in Korean newspapers. For this purpose, 1,725 articles on 'aging' or 'elderly' appeared on three major Korean newspapers during 1997- 2006 are analyzed. It is shown that there is a recent surge of articles portraying the positive images of aging in Korean newspapers emphasizing the importance of productive, successful aging and active life style of the elderly. This trend is a welcomed change from the negative images of elderly as dependent burden of society. However, it seems that over emphasis on positive aging and 'New Elderly' might have created another stereotype about the elderly and unintentionally marginalize the certain group of the elderly. By focusing on individual responsibility, it also overlooked the constraints imposed by social structure on disadvantaged elderly group, such as women, elderly in low socio-economic strata. Theoretical and policy implications of this trends are discussed.

• 한국노년학
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• v.28 no.4
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• pp.815-829
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• 2008

The purpose of the present study was to review psychological studies which have appeared in the "Journal of the Korean Gerontological Society". All told, 130 psychological papers have published for the last 30 years. Nineteen studies appeared in the 1980's, among which were 14 empirical ones and the remainders were review papers. In the 1990's were 51 papers published, and 49 ones were empirical and the rest of 2 literature review ones. In the 2000's did 56 papers appear, among which 56 ones were empirical and the rest of 4 literature review or theoretical ones. Research topics mainly examined about the aged were about mental health, life satisfaction and leasure, parent care and family relations, developmental change in cognition, and the old age general. After review of research trends for the last three decades, findings on each of research topics were examined. Finally, some limitations on the previous studies and future research directions were mentioned.