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http://dx.doi.org/10.7318/KJFC/2021.36.6.633

Neuroprotective Effect of Wild Radish Extract on Scopolamine Induced Memory Impairment  

Hur, Jinyoung (Korea Food Research Institute)
Choi, Sang Yoon (Korea Food Research Institute)
Yeom, Mijung (College of Korean Medicine, Kyung Hee University)
Publication Information
Journal of the Korean Society of Food Culture / v.36, no.6, 2021 , pp. 633-639 More about this Journal
Abstract
Raphanus sativus var. hortensis f. raphanistroides Makino (Korean wild radish [WR]) are root vegetables belonging to the Brassicaceae family. These radish species mostly grow in sea areas in Asia, where they have been traditionally used as a medicinal food to treat various diseases. To investigate the effect of WR on neuronal cell death in SH-SY5Y cells, beta-amyloid was used to develop the cell death model. WR attenuated neuronal cell death in SH-SY5Y and regulated the mitogen-activated protein kinase (MAPK) signaling. WR extract also inhibited acetylcholinesterase inhibitor activity. Additionally, the WR treatment group ameliorated the behavior of the memory-impaired mice in a scopolamine-induced mouse model. In the behavior test, WR treated mice showed shorter escape latency and swimming distance and improved the platform-crossing number and the swimming time within the target quadrant. Furthermore, WR prevented histological loss of neurons in hippocampal CA1 regions induced by scopolamine. This study shows that WR can prevent memory impairment which may be a crucial way for the prevention and treatment of memory dysfunction and neuronal cell death.
Keywords
Alzheimer's disease; raphanus sativus var. hortensis f. raphanistroides; korean wild radish; memory impairment; neuronal cell death;
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