Browse > Article
http://dx.doi.org/10.11002/kjfp.2018.25.1.90

In vitro correlation between anti-inflammatory and anti-oxidant effects of stone and seed of peaches cultivars  

Jung, Kyung-Mi (Cheongdo Peach Research Institute, GyeongSangBuk-Do Agricultural Technology Administration)
Bae, Seung-hwa (Department of Predictive Toxicology, Korea Institute of Toxicology)
Publication Information
Food Science and Preservation / v.25, no.1, 2018 , pp. 90-97 More about this Journal
Abstract
Peach seeds contain a large amount of phenolic components and exhibit excellent physiological effects in various diseases. We examined the antioxidant effects of stone and seed of three peach cultivars (Miwhang, MH; Kanoiwa hakuto, KH; and Cheonhong, CH) by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, ferric reducing activity of plasma (FRAP) assay, and cupric ion reducing antioxidant capacity (CUPRAC) reduction. The results showed that the stone extracts of CH had higher levels of total phenols and flavonoids than those of the other cultivars do, and the stone extracts of KH and CH have the potential to reduce DPPH, FRAP, and CUPRAC activities. In addition, we found that KH, MH, and CH stone extracts decreased nitric oxide generation in RAW 264.7 and BV2 cells. The total phenol and flavonoid contents had no significant correlation with anti-oxidant activities. On the other hand, the anti-inflammatory activity had a low linear correlation with anti-oxidant activities and total phenol and flavonoid contents. The present results suggest that the correlation between antioxidant and anti-inflammatory effects of stone and seed, and the appropriate combination of the stone and seed extracts could be used as an anti-inflammatory treatment and prevention material, respectively.
Keywords
Prunus persica; stone; seed; anti-oxidant; anti-inflammatory;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zhishen J, Mengcheng T, Jianming W (1999) The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem, 64, 555-559
2 Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200
3 Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem, 239, 70-76
4 Apak R, Guclu K, Ozyurek M, Karademir SE (2004) Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. J Agric Food Chem, 52, 7970-7981
5 Hammerstone JF, Lazarus SA, Schmitz HH (2000) Procyanidin content and variation in some commonly consumed foods. J Nutr, 130, 2086-2092
6 Kim YJ (2009) Evaluation of Antioxidant activity and thermal stability of plant polyphenols. Biomater Res, 13, 30-36
7 Bonina F, Lanza M, Montenegro L, Puglisi C, Tomaino A, Trombetta D, Castelli F, Saija A (1996) Flavonoids as potential protective agents against photo-oxidative skin damage. Int J Pharm, 145, 87-94
8 Di Carlo G, Mascolo N, Izzo AA, Capasso F (1999) Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci, 65, 337-353
9 Chrzczanowicz J, Gawron A, Zwolinska A, de Graft-Johnson J, Krajewski W, Krol M, Markowski J, Kostka T, Nowak D (2008) Simple method for determining human serum 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity-possible application in clinical studies on dietary antioxidants. Clinic Chem Lab Med, 46, 342-349
10 Chen S, Shen X, Cheng S, Li P, Du J, Chang Y, Meng H (2013) Evaluation of garlic cultivars for polyphenolic content and antioxidant properties. PLoS One, 8, e79730
11 Yoo KM, Kim DO Lee CY (2007) Evaluation of different methods of antioxidant measurement. Food Sci Biotechnol, 16, 177-182
12 Ozyurek M, Bektasoglu B, Guclu K, Apak R (2008) Hydroxyl radical scavenging assay of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method using catalase for hydrogen peroxide degradation. Anal Chim Acta, 616, 196-206
13 Kim TY (2013) Effect of Gagam-Danguieumja through regulation of MAPK on LPS-induced inflammation in RAW 264.7 cells. Korean J Orient Internal Med, 34, 339-348
14 Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends neurosci, 19, 312-318
15 Cheong MH, Lee SR, Yoo HS, Jeong JW, Kim GY, Kim WJ, Jung IC, Choi YH (2011) Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-${\kappa}B$ activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol, 137, 1402-1408
16 Lee DS, Woo SK, Yang CB (1972) Studies on the chemical composition of major fruits in Korea:On non-volatile organic acid and sugar contents of apricot (maesil), peach, grape, apple and pear and its seasonal variation. Korean J Food Sci Technol, 4, 134-139
17 Ji EJ, Yoo KM, Park JB, Hwang IK (2008) Preparation of citron peel tea containing yuza (Citrus junos Seib ex TANAKA) and its antioxidant characteristics. Korean J Food Cookery Sci, 24, 460-465
18 Ho CT, Chen Q, Shi H, Zhang KQ, Rosen RT (1992) Antioxidative effect of polyphenol extract prepared from various Chinese teas. Prev Med, 21, 520-525
19 Yoo SJ, Kim SH, Jun MS, Oh HT, Choi HJ, Ham SS (2007) Antioxidative, antimutagenic and cytotoxic effects of Prunus armeniaca extracts. Korean J Food Preserv, 14, 220-225
20 Hwang IW, Lee HR, Kim SK, Zheng HZ, Choi JU, Lee SH, Lee SH, Chung SK (2008) Proanthocyanidin content and antioxidant characteristics of grape seeds. Korean J Food Preserv, 15, 859-863
21 Cha BC, Lee EH (2004) Antioxidant and antiinflammation activities of Prunus persica tree extracts. Korean J Med crop Sci, 12, 289-294
22 Lee KH, Jang HJ, Lee YJ, Choi JH (2014) Changes in the chemical components and antioxidant activity of peach (Prunus persica L. Batsch) by hot air treatment. Korean J Food Nutr, 27, 219-224
23 Park KK (2008) Studies on functions of Prunus persica to develop as the functional food. Report of Rural Development Administration RDA SE0000106586, Suwon, Korea, p 18-26
24 Yun IH, Seo BI, Kim SH (1996) The effect of Persicae Semen on the artherosclerosis in rabbit. Korean J Herbol, 11, 79-79
25 Lee JY, Hong SG, Choi SW (2000) Inhibition of enzymatic browning of apple juices by benzoic acid isolated from peach (Prunus persica Batsch) seeds. Korean J Postharvest Sci Technol, 7, 103-107
26 Folin O, Denis W (1912) On phosphotungsticphosphomolybdic compounds as color reagents. J Biol Chem, 12, 239-243
27 Kim JK, Lee CJ, Park TW, Chai YG (1999) Protective effect of peach kernel extracts on radiation-induced DNA damage in human blood lymphocytes in the comet assay. Paper presented at 1999 spring meeting of the Korean Nuclear Society, May 28-29, Taejon, Korea