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http://dx.doi.org/10.11002/kjfp.2017.24.7.1017

Protective effect of Litsea japonica fruit flesh extract on indomethacin-induced gastritis in rats  

Park, Sung-Hwan (Hurum Central research institute Co., Ltd.)
Park, In-Jae (Hurum Central research institute Co., Ltd.)
Yun, Ji-Hyun (Hurum Central research institute Co., Ltd.)
Choi, Goo-Hee (Hurum Central research institute Co., Ltd.)
Kim, Hyun-Jung (Hurum Central research institute Co., Ltd.)
Seo, Yun-Hee (EBO Co., Ltd.)
Cho, Ju-Hyun (Hurum Central research institute Co., Ltd.)
Publication Information
Food Science and Preservation / v.24, no.7, 2017 , pp. 1017-1024 More about this Journal
Abstract
The objective of this study was to investigate the inhibitory effects of Litsea japonica fruit flesh extract (LJF-HE) on gastritis in an indomethacin-induced SD rat model. Rats were randomly divided into six groups: G1 (normal group), G2 (control group, indomethacin-induced gastritis), G3 (positive group, indomethacin-induced gastritis and ranitidine 50 mg/kg), G4 (LJF-HE-L group, indomethacin-induced gastritis and L. japonica fruit flesh extract at 30 mg/kg), G5 (LJF-HE-M group, indomethacin-induced gastritis and L. japonica fruit flesh extract at 60 mg/kg), G6 (LJF-HE-H group, indomethacin-induced gastritis and L. japonica fruit flesh extract at 120 mg/kg). In the group treated with LJF-HE (G4, G5, and G6), gastric mucosal damage, gastric juice secretion and pepsin activity were significantly decreased compared to the control group. Additionally, there were decreases in the expression of cholecystokinin 2 receptor (CCK-2r), histamine receptor H2 (H2r) and H+/K+ ATPase in the gastric lesions. The plasma levels of TNF-${\alpha}$ and IL-$1{\beta}$ significantly decreased in LJF-HE (G4, G5, and G6) treated groups compared with control. The plasma level of PGE2 was also significantly increased by LJF-HE (G5 and G6). These results suggest that LJF-HE (G4, G5, and G6) has the ability to inhibit on indomethacin-induced gastritis.
Keywords
Litsea japonica; gastritis; indomethacin; gastric ulcer;
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Times Cited By KSCI : 5  (Citation Analysis)
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