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http://dx.doi.org/10.11002/kjfp.2014.21.1.91

A study to reduce the intestinal transport of endosulfan by indole  

Gong, Daecheol (Department of Food and Nutrition, Changwon National University)
Kim, Juyeon (Department of Food and Nutrition, Changwon National University)
Choi, Hansol (Department of Food and Nutrition, Changwon National University)
Noh, Sang Kyu (Department of Food and Nutrition, Changwon National University)
Publication Information
Food Science and Preservation / v.21, no.1, 2014 , pp. 91-96 More about this Journal
Abstract
Evidence suggests that dietary indole, particularly rich in cruciferous vegetables, may reduce the risk of cardiovascular diseases. Endosulfan is a residual organochlorine pesticide, which is detected in fruits, vegetables, and crops. In this study, we investigated the effect of luminal indole on endosulfan transport in the small intestine in mesenteric lymph duct-cannulated rats. The duodenum was also cannulated and a fasting phosphate buffered saline-glucose solution was infused overnight at 3 mL/hr. After recovery, a lipid emulsion containing [2,3-$^{14}C$] endosulfan ($^{14}C$-endosulfan) was infused into the duodenum for 8 hours. The tested rats were infused with the same lipid emulsion, but with indole. Samples from the lymph-fistula were collected hourly, and the luminal contents and mucosa were collected at the end of the infusion. The lymph flow in the mesenteric lymph did not differ between the two groups. However, the intestinal absorption of both endosulfan and cholesterol were significantly decreased by indole. The amount of radioactive endosulfan, which remained in the mucosa, was greater in the indole-infused rats due to the decreased transport of endosulfan into the lymph. This study indicates that the indole decreases the intestinal transport of endosulfan into the mesenteric lymph.
Keywords
absorption; endosulfan; indole; lymph; rats;
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