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http://dx.doi.org/10.11002/kjfp.2014.21.1.107

Effect of the supplementation of Coconopsis lanceolata extract on lipid metabolism amelioration in type 2 diabetes mouse model induced by high fat diet  

Yun, Won-Kap (Department of Food Science and Biotechnology, Andong National University)
Bae, Hyun-Ji (Department of Food Science and Biotechnology, Andong National University)
Kim, You-Jeong (Department of Food Science and Biotechnology, Andong National University)
Kwon, O Jun (Gyeongbuk Regional Innovation Agency)
Im, Moo Hyeog (Food Standards Division, Korea Food and Drug Administration)
Cho, Hyun Duk (Ulleung Eokcheon Food Company)
Kim, Taewan (Department of Food Science and Biotechnology, Andong National University)
Publication Information
Food Science and Preservation / v.21, no.1, 2014 , pp. 107-113 More about this Journal
Abstract
The present study was designed to investigate the antihyperlipidemic effect of Coconopsis lanceolata extract in C57BL/6J mice. The mice were divided into four groups: normal diet group (ND), high fat diet group (HFD), positive control group with 0.05% metformin (PC), Coconopsis lanceolata extract group (UCL). After 5 weeks of feeding, average body weight of the UCL group mice was slightly decreased, while that of the HFD group significantly increased) Also, liver and adipose tissue weights in the UCL group significantly increased. The levels of trigliceride (TG) and total in the plasma of UCL-supplemented group were significantly lower than those of high fat diet group. On the other hand, HDL-cholesterol level was increased. Expression level of proteins related with adipogenesis such as SREBP-1c, ACC, and FAS in the liver of the UCL group mice was much lower comparing with the HFD group mice. In conclusion, the results showed that the Coconopsis lanceolata extract possesses significant antihyperlipidemic effects in C57BL/6J mice.
Keywords
Codonopsis lancelata; diabetes mellitus; triglyceride; total cholesterol; hdl-cholesterol;
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Times Cited By KSCI : 4  (Citation Analysis)
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