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http://dx.doi.org/10.11002/kjfp.2011.18.1.053

Pancreatic Lipase Inhibitors in the Roots of Taraxacum ohwianum, a Herb Used in Korean Traditional Medicine  

Kim, Tae-Wan (Department of Food Science and Biotechnology, Andong National University)
Kim, Tae-Hoon (Department of Herbal Medicinal Pharmacology, Daegu Haany University)
Publication Information
Food Science and Preservation / v.18, no.1, 2011 , pp. 53-58 More about this Journal
Abstract
Activity-guided isolation from an ethylacetate-soluble fraction of a 70% (v/v) ethanolic extract from the roots of Taraxacum ohwianum, using a pancreatic lipase inhibition assay, resulted in isolation and identification of five phenolic metabolites of previously known structure; these were 3,5-di-O-caffeoylquinic acid, chicoric acid, caffeic acid, protocatechuic aldehyde, and luteolin. All structures were confirmed by NMR and MS scpectroscopic data. Of these compounds 3,5-di-O-caffeoylquinic acid exhibited the most potent inhibitory activity, with $IC_{50}$ of $65.1{\pm}0.7\;{\mu}M$ against pancreatic lipase.
Keywords
Taraxacum ohwianum; pancreatic lipase inhibition; caffeic acid derivatives;
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Times Cited By KSCI : 2  (Citation Analysis)
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