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Effect of Low-Molecular-Weight Collagen Peptide Extract Isolated from Scales of the Flathead Mullet (Mugil cephalus) on Lipid Metabolism in Hyperlipidemic Rats  

Kim, Han-Soo (Department of Food Science & Technology, Pusan National University)
Seong, Jong-Hwan (Department of Food Science & Technology, Pusan National University)
Lee, Young-Guen (Department of Food Science & Technology, Pusan National University)
Xie, Cheng-Liang (Department of Food Science & Technology, Pusan National University)
Choi, Woo-Seok (Department of Food Science & Technology, Pusan National University)
Kim, Su-Ha (Department of Food Science & Technology, Pusan National University)
Yoon, Ho-Dong (Food & Safety Research Center, National Fisheries Research & Development Institute)
Publication Information
Food Science and Preservation / v.16, no.6, 2009 , pp. 938-945 More about this Journal
Abstract
The objective of this study was to investigate the effects of ingestion of low-molecular-weight collagen peptides on lipid composition, blood glucose level, and enzyme activities in the serum of hyperlipidemic rats fed experimental diets for 5 weeks. Concentrations of total cholesterol, low-density lipoprotein (LDL)-cholesterol, free cholesterol, triglyceride (TG), phospholipid (PL), and blood glucose, the atherosclerotic index, and the cholesteryl ester ratio were higher in serum of the hyperlipidemic group (CW group), and the cholesterol-plus-collagen peptides extract group (CCP group) than in the control group (BG group basal diet plus water). However, the concentrations of total cholesterol, LDL-cholesterol, free cholesterol, TG, PL, and blood glucose, the atherosclerotic index, and the cholesteryl ester ratio in serum were lower in the CCP group than in the CW group. By contrast, the ratio of HDL-cholesterol to total cholesterol and the absolute HDL-cholesterol level in the CCP group were higher than in the CW group. The activities of alkaline phosphatase (ALP) and aminotransferases (AST, ALT) in serum were lower in the CCP group than in the hyperlipidemic CW group. The results indicate that an extract of low-molecular-weight collagen peptides effectively inhibited increases in lipid elevation, blood glucose level, and enzyme activities, in the serum of hyperlipidemic rats.
Keywords
Hyperlipidemia; collagen peptide; lipid component; blood glucose; enzyme activity;
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