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Antioxidative, Antimutagenic and Cytotoxic Effects of Prunus armeniaca Extracts  

Yoo, Su-Jung (School of Bioscience and Biotechnology, Kangwon National University)
Kim, Soo-Hyun (School of Bioscience and Biotechnology, Kangwon National University)
Jun, Mi-Sun (School of Bioscience and Biotechnology, Kangwon National University)
Oh, Hyun-Taek (School of Bioscience and Biotechnology, Kangwon National University)
Choi, Hyun-Jin (School of Bioscience and Biotechnology, Kangwon National University)
Ham, Seung-Si (School of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Food Science and Preservation / v.14, no.2, 2007 , pp. 220-225 More about this Journal
Abstract
This study was performed to measure the antioxidative, antimutagenic, and cytotoxic properties of Prunus armeniaca using the DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical donating method, the Ames test, and cytotoxicity measurements, respectively. Electron-donating abilities were 48.3, 43.9, 14.8 and 12.9 per g dry matter of P. armeniaca seed (PAS), P. armeniaca flesh(PAF), butylated hydroxytoluene, and ${\alpha}-tocopherol$, respectively. The direct antimutagenic effects of an ethanol extract of P. armeniaca were examined in Ames tests using Salmonella typhimurium TA98 and TA100 as reporter organisms. In the Ames test, the ethanol extract of P. armenicaca alone did not exhibit any mutagenicity but the extract did show substantial inhibitory effects against mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and 4-nitroquinoline-1-oxide(4NQO). The ethanol extract of PAS(200g dry matter/plate) inhibited strain TA98 mutagenesis induced by 4NQO by ca. 37.9%, and mutation inhibition values of 42.1% and 69.4%, respectively, were observed when 4NQO and MNNG acted on the TA100 strain. The cytotoxic effects of ethanol extracts of P. armeniaca against cell lines of human lung carcinoma(A549), human breast adenocarcinoma(MCF-7), human hepatocellular carcinoma(Hep3B), human cervical adenocarcinoma(HeLa), and human gastric carcinoma(AGS) rose with increases in extract concentration. An ethanol extract(4mg/mL dry matter) of PAF showed strong cytotoxicities of 88.2%, 58%, 72.8%, 89.4%, and 91.9% against A549, AGS, MCF-7, HeLa, and Hep3B cells, respectively. In contrast, the same extract showed only 13 37% cytotoxicity for a nomal human kiney cell line(293). It is suggested that P. armeniaca possesses useful antioxidative, antimutagenic, and anticancer properties.
Keywords
Prumus armeniacea; antiioxidation; antimutagenicity; cytotoxicity;
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Times Cited By KSCI : 9  (Citation Analysis)
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