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Antimutagenic and Cytotoxic Effects of Allium victorialis Extracts  

함승시 (강원대학교 바이오산업공학부)
최승필 (강원대학교 바이오산업공학)
최형택 ((주)신원에프아)
이득식 (동해대학교 외식산업학과)
Publication Information
Food Science and Preservation / v.11, no.2, 2004 , pp. 221-226 More about this Journal
Abstract
This study was carried out to determine the antimutagenic and anticancer effects of Allium victoriolis using Ames test and cytotoxicity. Allium victorialis extracted with ethanol and then further fractionated to chloroform, ethyl acetate and water. The inhibition rate of ethanol extract (200 $\mu\textrm{g}$/plate) of Allium victorialis in the Salmonella typhimurium TA100 strain showed 88.2% against the mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). The suppression ratio against 4-nitroquinoline-1-oxide(4NQO) in the Salmonella typhimurium TA98 and TA100 strains showed 76.4% and 83.0%, respectively. The cytotoxicity effects of Allium victorialis extract against the cell lines with human lung carcinoma (A549), human breast adenocarcinoma (MCF-7) and human gastric cacinoma (KATOIII) were inhibited with the increase of extract concentration. The treatment of 0.5 $\mu\textrm{g}$/plate Allium victorialis of ethanol extract showed strong cytotoxicities of 74.2%, 71.3% and 67.4% against A549, MCF-7 and KATOIII, respectively.
Keywords
Allium victorialis; antimutagenicity; cytotoxicity;
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