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http://dx.doi.org/10.3746/jkfn.2017.46.9.1137

Anti-Visceral Obesity Effect of Apios americana Medikus in Diet-Induced Obese Mice  

Choi, Ra-Yeong (Department of Food & Nutrition, Sunchon National University)
Lee, Jin (Department of Food & Nutrition, Sunchon National University)
Ryu, Hyo-Seon (Department of Food & Nutrition, Sunchon National University)
Ham, Ju Ri (Department of Food & Nutrition, Sunchon National University)
Park, Seok-Kyu (Department of Food & Nutrition, Sunchon National University)
Kim, Myung-Joo (Department of Bakery & Barista, Suseong College)
Lee, Mi-Kyung (Department of Food & Nutrition, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.46, no.9, 2017 , pp. 1137-1142 More about this Journal
Abstract
This study examined the effects of apios (Apios americana Medikus) supplementation on visceral obesity in high-fat diet-induced obese mice. C57BL/6N mice were fed a high-fat diet (40% calories from fat) with or without apios powder (10%, w/w) for 12 weeks. At the end of the experiment, apios supplementation reduced visceral fat mass significantly by 14.3% compared to the control group. Apios decreased significantly the atherogenic index, serum leptin level, hepatic lipid (free fatty acid and triglyceride) content, and lipid droplets, whereas it increased the serum high density lipoprotein-cholesterol/total cholesterol ratio. Hepatic lipogenic gene expression of peroxisome proliferator activated receptor gamma, fatty acid synthase, and diacylglycerol O-acyltransferase 2 was down-regulated by apios supplementation. These results suggest that apios is a healthy food for preventing high-fat diet-induced visceral obesity and fatty liver.
Keywords
apios; atherogenic index; hepatic lipid; obesity; visceral fat;
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