Browse > Article
http://dx.doi.org/10.3746/jkfn.2017.46.9.1027

Immunomodulatory Effects of an Extract from Pinus koraiensis Cone Peel in LP-BM5 Murine Leukemia Viruses-Induced Murine Acquired Immune Deficiency Syndrome  

Kim, Seong Pil (Department of Gerontology, Kyung Hee University)
Kwon, Han Ol (Department of Medical Nutrition, Kyung Hee University)
Ha, Yejin (Department of Medical Nutrition, Kyung Hee University)
Heo, Seok Hyun (Korea Health Supplements Association)
Lee, Jeongmin (Department of Medical Nutrition, Kyung Hee University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.46, no.9, 2017 , pp. 1027-1034 More about this Journal
Abstract
The immune system is a complex process within the body that protects against disease. Recently, many studies have attempted to discover immunomodulative compounds from natural sources. Pinus koraiensis (PK) cone shell is a by-product of PK. One of the major compounds of PK cone shell is dehydroabietic acid, which has bioactivity, including antiulcer and anti-inflammatory activities. Therefore, this study was performed to examine the immunomodulative effects of PK cone shell. The immunomodulatory effects of PK cone shell extracted with 20% ethanol (EtOH) in vivo were examined initially by measuring the natural killer (NK) cell activity, phagocytic activity, Th1/Th2 cytokines release, serum immunoglobulin, and T/B cell proliferation. The NK cell activity and phagocytic activity were increased significantly by a treatment with a 20% EtOH extract of PK cone shell. Th1 type cytokine and T cell proliferation increased and Th2 type cytokine, B cell proliferation and serum immunoglobulin A, G, and E decreased after a treatment with PK cone shell extract. The 20% EtOH extract of the PK cone shell normalized the unbalanced production of Th1/Th2 type cytokine. This suggests that a 20% EtOH extract of PK cone shell has great potential as a health food.
Keywords
pine cone; Pinus koraiensis; immunomodulatory effect; cytokines; immune deficiency syndrome;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Liang B, Jiang S, Zhang Z, Inserra P, Lee J, Solkoff D, Watson RR. 2001. Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection. Immunopharmacol Immunotoxicol 23: 307-319.   DOI
2 Moir S, Malaspina A, Li Y, Chun TW, Lowe T, Adelsberger J, Baseler M, Ehler LA, Liu S, Davey RT Jr, Mican JA, Fauci AS. 2000. B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells. J Exp Med 192: 637-646.   DOI
3 Peacock CD, Price P. 1999. The role of IL-12 in the control of MCMV is fundamentally different in mice with a retroviral immunodeficiency syndrome (MAIDS). Immunol Cell Biol 77: 131-138.   DOI
4 Del Toro-Arreola S, Flores-Torales E, Torres-Lozano C, Del Toro-Arreola A, Tostado-Pelayo K, Guadalupe Ramirez-Dueñas M, Daneri-Navarro A. 2005. Effect of D-limonene on immune response in BALB/c mice with lymphoma. Int Immunopharmacol 5: 829-838.   DOI
5 Willoughby DA. 1974. Heberden Oration, 1974. Human arthritis applied to animal models. Towards a better therapy. Ann Rheum Dis 34: 471-478.
6 Tomasi TB Jr, Tan EM, Solomon A, Prendergast RA. 1965. Characteristics of an immune system common to certain external secretions. J Exp Med 121: 101-124.   DOI
7 Gasparis AP, Tassiopoulos AK. 2001. Nutritional support in the patient with HIV infection. Nutrition 17: 981-982.   DOI
8 Piot P, Bartos M, Ghys PD, Walker N, Schwartlander B. 2001. The global impact of HIV/AIDS. Nature 19: 968-973.
9 Lee YW, Hirani AA, Kyprianou N, Toborek M. 2005. Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells. Inflamm Res 54: 380-389.   DOI
10 Li W, Green WR. 2006. The role of CD4 T cells in the pathogenesis of murine AIDS. J Virol 80: 5777-5789.   DOI
11 Lee JM. 2006. Dehydroepiandrosterone sulfate inhibited immune dysfunction induced by LP-BM5 leukemia retrovirus infection through regulating Th1/Th2 type cytokine mRNA expression and oxidative stress in murine AIDS model. J Korean Soc Food Sci Nutr 35: 1329-1335.   DOI
12 Greenspan HC, Aruoma OI, Arouma O. 1994. Could oxidative stress initiate programmed cell death in HIV infection? A role for plant derived metabolites having synergistic antioxidant activity. Chem Biol Interact 91: 187-197.   DOI
13 Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M, Nabeshima T. 2000. Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-${\alpha}$ gene. FASEB J 14: 1023-1031.   DOI
14 Tong H, Song X, Sun X, Sun G, Du F. 2011. Immunomodulatory and antitumor activities of grape seed proanthocyanidins. J Agric Food Chem 21: 11543-11547.
15 Huh SH. 2014. Health functional food market trends and consumer survey. Korea Health Supplements Association, Seongnam, Korea.
16 Su XY, Wang ZY, Liu JR. 2009. In vitro and in vivo antioxidant activity of Pinus koraiensis seed extract containing phenolic compounds. Food Chem 117: 681-686.   DOI
17 Lee HJ, Choi YJ, Choi DH, Hong IP. 2003. Extractives of Pinus koraiensis wood. Mokchae Konghak 31: 49-56.
18 Caldefie-Chezet F, Guerry M, Chalchat JC, Fusillier C, Vasson MP, Guillot J. 2004. Anti-inflammatory effects of Melaleuca alternifolia essential oil on human polymorphonuclear neutrophils and monocytes. Free Radic Res 38: 805-811.   DOI
19 Hwang HJ, Yu JS, Lee HY, Kwon DJ, Han W, Heo SI, Kim SY. 2014. Evaluations on deodorization effect and anti-oral microbial activity of essential oil from Pinus koraiensis. Korean J Plant Res 27: 1-10.   DOI
20 Jolicoeur P. 1991. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J 5: 2398-2405.   DOI
21 Odeleye OE, Eskelson CD, Watson RR. 1992. Changes in hepatic lipid composition after infection by LP-BM5 murine leukemia virus causing murine AIDS. Life Sci 51: 129-134.   DOI
22 Lee J, Park CS, Chung MY, Cho DH, Watson RR. 2005. Reduced micronutrient intake accentuates premature death caused by immune dysfunction in leukemia retrovirus-infected C57BL/6 mice. Nutr Res 25: 401-412.   DOI
23 Liang B, Wang JY, Watson RR. 1996. Murine AIDS, a key to understanding retrovirus-induced immunodeficiency. Viral Immunol 9: 225-239.   DOI