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http://dx.doi.org/10.3746/jkfn.2017.46.8.910

Red Ginseng Alters Lipid Metabolism through AMPK Activation in Liver and Adipose Tissues of High-Fat Diet-Fed Mice  

Jeong, Ha Jin (Department of Biomedical Sciences, Chonnam National University)
Oh, Seung Tack (Department of Biomedical Sciences, Chonnam National University)
Liu, Quan Feng (Department of Biomedical Sciences, Chonnam National University)
Choi, Yura (Department of Biomedical Sciences, Chonnam National University)
Lee, Seoungmi (Department of Biomedical Sciences, Chonnam National University)
Jeon, Songhee (Department of Biomedical Sciences, Chonnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.46, no.8, 2017 , pp. 910-918 More about this Journal
Abstract
Hyperlipidemia is known as a glucose and lipid metabolism-related disorder that is increasing in incidence in modern society. Red ginseng (RG) is a natural herb candidate with a positive effect on regulation of cholesterol and lipids. To observe the effects of RG on regulation of lipids, cholesterol, glucose, and oxidative stress, we examined the in vitro and in vivo effects of Chamdahan RG on differentiated 3T3-L1 adipocytes and high-fat diet-fed mice. RG ($50{\mu}g/mL$) significantly inhibited lipid synthesis in 3T3-L1 cells. In addition, a low concentration of RG (880 mg/kg/d) resulted in the lowest total blood cholesterol level. Moreover, high density lipoprotein-cholesterol quantity increased in RG-treated groups, consequently lowering the cardiovascular risk factor and atherosclerosis index. Moreover, RG increased activity of AMP-activated protein kinase, as a regulator of lipid and cholesterol synthesis, in adipose and liver tissues. Cumulatively, this paper suggests that RG has a positive effect on reducing the amounts of cholesterol and lipids and may be a good candidate for treating hyperlipidemia.
Keywords
red ginseng; hyperlipidemia; AMPK; high density lipoprotein-cholesterol;
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