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http://dx.doi.org/10.3746/jkfn.2017.46.4.523

Effects of Extracts of Five Species of Korean Native Forest Plants on Lipid Accumulation and Reactive Oxygen Species Production during Differentiation of 3T3-L1 Preadipocytes  

Choi, Sun-Il (Department of Food Science and Biotechnology, Kangwon National University)
Lee, Jong Seok (Biological and Genetic Resources Assessment Division, National Institute of Biological Resources)
Lee, Sarah (Biological and Genetic Resources Assessment Division, National Institute of Biological Resources)
Lee, Hye Jin (Biological and Genetic Resources Assessment Division, National Institute of Biological Resources)
Yeo, Joohong (Biological and Genetic Resources Assessment Division, National Institute of Biological Resources)
Cho, Bong-Yeon (Department of Food Science and Biotechnology, Kangwon National University)
Lee, Jin-Ha (Department of Food Science and Biotechnology, Kangwon National University)
Kim, Jae-Min (Department of Food Science and Biotechnology, Kangwon National University)
Jung, Tae-Dong (Department of Food Science and Biotechnology, Kangwon National University)
Choi, Seung-Hyun (Department of Food Science and Biotechnology, Kangwon National University)
Kim, Jong-Yea (Department of Food Science and Biotechnology, Kangwon National University)
Kang, Suk-Nam (Department of Animal Resource, Daegu University)
Lee, Ok-Hwan (Department of Food Science and Biotechnology, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.46, no.4, 2017 , pp. 523-528 More about this Journal
Abstract
This study investigate the effects of extracts of five species of Korean native forest plants on lipid accumulation and reactive oxygen species (ROS) production during the differentiation of 3T3-L1 cells. Our results show that Korean native forest plants extracts significantly reduced lipid accumulation and ROS production during adipogenesis in 3T3-L1 cells. Especially, Rubus coreanus Miq. was most effective in the inhibition of lipid accumulation and ROS production at a concentration of $100{\mu}g/mL$. Moreover, Rubus coreanus Miq. extracts significantly inhibited adipocyte differentiation, which is dependent on down-regulation of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, and adipocyte-specific fatty acid binding protein, a key adipogenic transcription factor. Therefore, these results suggest that Rubus coreanus Miq. might be a valuable source of bioactive compounds with anti-adipogenic activity.
Keywords
3T3-L1 cell; adipocyte differentiation; lipid accumulation; reactive oxygen species; Korean native forest plants;
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Times Cited By KSCI : 8  (Citation Analysis)
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