The Effects of Sinetrol-XPur on Lipolysis of Leptin-Deficient Obese Mice |
Lee, Minhee
(Graduate School of East-West Science, Kyung Hee University)
Kwon, Han Ol (Graduate School of East-West Science, Kyung Hee University) Choi, Sei Gyu (RP Corp Co., Ltd.) Bae, Mun Hyoung (RP Corp Co., Ltd.) Kim, Ok-Kyung (Beirne B. Carter Center for Immunology Research, University of Virginia) |
1 | Korea Health Statistics. 2015. Korea Health Statistics 2014: Korea National Health and Nutrition Examination Survey (KNHANES VI-2). Ministry of Health and Welfare, Sejong, Korea. p 50. |
2 | Chua SC, Leibel RL. 1996. Obesity genes: Molecular and metabolic mechanisms. Diabetes Reviews 5: 2-7. |
3 | Spiegelman BM, Flier JS. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389. DOI |
4 | Xiong Y, Qu Z, Chen N, Gong H, Song M, Chen X, Du J, Xu C. 2014. The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue. Mol Cell Endocrinol 392: 106-114. DOI |
5 | Aubert J, Champigny O, Saint-Marc P, Negrel R, Collins S, Ricquier D, Ailhaud G. 1997. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem Biophys Res Commun 238: 606-611. DOI |
6 | Chae MH, No JG, Jhon DY. 2007. Hangbisan, sulfur-based oriental medicine, lowers the blood cholesterol levels of ob/ob obese mice. J Korean Soc Food Sci Nutr 36: 27-31. DOI |
7 | Ingalls AM, Dickie MM, Snell GD. 1996. Obese, a new mutation in the house mouse. Obes Res 4: 101. DOI |
8 | Yum KS. 2001. Orlistat (XenicalR). Korean J Obesity 10: 25-36. |
9 | Padwal RS, Majumdar SR. 2007. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 369: 71-77. DOI |
10 | Dallas C, Gerbi A, Elbez Y, Caillard P, Zamaria N, Cloarec M. 2014. Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals. Phytother Res 28: 212-218. DOI |
11 | Kuppusamy UR, Das NP. 1992. Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. Biochem Pharmacol 44: 1307-1315. DOI |
12 | Chen D, Daniel KG, Kuhn DJ, Kazi A, Bhuiyan M, Li L, Wang Z, Wan SB, Lam WH, Chan TH, Dou QP. 2004. Green tea and tea polyphenols in cancer prevention. Front Biosci 9: 2618-2631. DOI |
13 | Frankel EN, German JB, Kinsella JE, Parks E, Kanner J. 1993. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-457. DOI |
14 | Yoo JM, Lee M, Kwon HO, Choi SG, Bae MH, Kim OK. 2016. Effects of Sinetrol-XPur on leptin-deficient obese mice and activation of cAMP-dependent UCP-2. J Korean Soc Food Sci Nur 45: 484-491. DOI |
15 | Landstrom TR, Mei J, Karlsson M, Manganiello V, Degerman E. 2000. Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor and cAMP. Biochem J 346: 337-343. DOI |
16 | Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E. 2006. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes. Cell Signalling 18: 382-390. DOI |
17 | Carmen GY, Victor SM. 2006. Signalling mechanisms regulating lipolysis. Cell Signalling 18: 401-408. DOI |
18 | Holm C. 2003. Molecular mechanisms regulating hormonesensitive lipase and lipolysis. Biochem Soc Trans 31: 1120-1124. DOI |
19 | Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS. 2006. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem 281: 15837-15844. DOI |
20 | Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. 2006. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737. DOI |