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http://dx.doi.org/10.3746/jkfn.2016.45.8.1202

Anti-Obesity Effect of Eriobotrya japonica Leaves Extract on Obese Mice Induced by High-Fat Diet  

Lee, Somi (Fruit Research Institute (Jeollanamdo Agricultural Research & Extension Service))
Park, Moonyoung (Fruit Research Institute (Jeollanamdo Agricultural Research & Extension Service))
Kim, Ok Kyung (Department of Medical Nutrition and Research Institute of Medical Nutrition, Kyung Hee University)
Lee, Jeongmin (Department of Medical Nutrition and Research Institute of Medical Nutrition, Kyung Hee University)
Jun, Woojin (Department Food and Nutrition, Chonnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.8, 2016 , pp. 1202-1207 More about this Journal
Abstract
This study investigated the anti-obesity effects of Eriobotrya japonica leaves extract (EJE) in a high-fat diet-induced obese mice model. For the analysis, 40 mice were randomly divided into five groups: normal diet (ND), high-fat diet group (HD), high-fat diet containing EJE 100 mg/kg b.w. (EJE-L), 500 mg/kg b.w. (EJE-H), and Garcinia cambogia extract 100 mg/kg b.w. in each AIN 93G supplement for 8 weeks as positive control. During the study period, food intake and body weight were measured separately. Body weight, serum triglyceride level, and total cholesterol levels of the EJE group were significantly lower than those of the HD and ND. Moreover, mice fed an EJE-containing high-fat diet showed decreased leptin levels compared with high-fat diet-induced obese mice. These results suggest that EJE has potential as an anti-obesity agent by reducing body weight and improving levels of triglycerides, total cholesterol, low density lipoprotein-cholesterol, and leptin in serum.
Keywords
Eriobotrya japonica; loquat; anti-obesity; cholesterol; leptin;
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