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http://dx.doi.org/10.3746/jkfn.2016.45.4.613

Anti-Allergic Effect of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose on RBL-2H3 Cells  

Kim, Yoon Hee (Department of Food and Nutrition, College of Engineering, Daegu University)
Choi, Ye Rang (Department of Food and Nutrition, College of Engineering, Daegu University)
Kim, Ji Young (Department of Food and Nutrition, College of Engineering, Daegu University)
Kwak, Sang Hee (Department of Food and Nutrition, College of Engineering, Daegu University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.4, 2016 , pp. 613-618 More about this Journal
Abstract
1,2,3,4,6-Penta-O-galloyl-${\beta}$-D-glucose (PGG) is a gallotannin isolated from various plants such as Galla Rhois. In a previous study, it was reported that PGG has anti-allergic effects by inhibiting interleukin (IL)-4 signaling in B cells. However, the effect of PGG on basophilic cells remains unclear. Therefore, the aim of this study was to investigate the inhibitory effect of PGG on mitogen and calcium ionophore-induced allergic responses. PGG had no effect on proliferation and cytotoxicity of RBL-2H3 cells. PGG significantly suppressed cell degranulation (histamine and ${\beta}-hexosaminidase$) as well as inflammatory cytokine production such as IL-4 and tumor necrosis factor-${\alpha}$. The underlying mechanism of PGG on these anti-allergic actions was correlated with inhibition on translocation of nuclear factor-${\kappa}B$ from the cytosol to nucleus. These data suggest that PGG is a potentially effective functional compound for prevention of allergic diseases.
Keywords
PGG; gallotannin; anti-allergy; RBL-2H3 cell;
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