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http://dx.doi.org/10.3746/jkfn.2016.45.4.501

Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves  

Cho, Byoung Ok (Research Institute, Ato Q&A Corporation)
Yin, Hong Hua (Research Institute, Ato Q&A Corporation)
Shin, Jae Young (Department of Health Care & Science, Jeonju University)
Fang, Chong Zhou (Department of Health Care & Science, Jeonju University)
Chang, Che Denis (Department of Health Care & Science, Jeonju University)
Jang, Seon Il (Research Institute, Ato Q&A Corporation)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.45, no.4, 2016 , pp. 501-509 More about this Journal
Abstract
The present study investigated the anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) on atopic dermatitis (AD)-like skin lesions in hairless mice. The in vivo results demonstrated that DPME treatment significantly reduced the dermatitis clinical score and epidermal thickness in AD-like skin lesions. Histological analyses showed that DPME treatment strongly inhibited dermal infiltration of inflammatory cells and activity of mast cells in AD-like skin lesions. DPME treatment inhibited production of serum IgE and interluekin (IL)-4 in hairless mice with AD. Moreover, DPME treatment significantly suppressed production of tumor necrosis factor $(TNF)-{\alpha}$ and IL-6 cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 human mast cells. In addition, DPME treatment reduced production of pro-inflammatory mediators (nitric oxide, prostaglandin E2, $TNF-{\alpha}$, and IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Therefore, the results of this study indicate that the anti-atopic and anti-inflammatory effects of DPME may be involved in the regulation of inflammatory responses, suggesting that DPME may be used as an anti-atopic dermatitis material and natural anti-inflammatory ingredient.
Keywords
date plum leaves; persimmon leaves; mulberry leaves; atopic dermatitis; inflammation;
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Times Cited By KSCI : 17  (Citation Analysis)
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