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http://dx.doi.org/10.3746/jkfn.2015.44.8.1105

Blood Flow Improvement Effect of Bokbunja (Rubus coreanus) Seed Oil in High-Fat Diet-Fed Mouse Model  

Jeon, Hyelin (Department of Biomedical Sciences, University of Ulsan College of Medicine)
Kwak, Sungmin (Department of Biomedical Sciences, University of Ulsan College of Medicine)
Oh, Su-Jin (JKberrynary)
Nam, Hyun Soo (JKberrynary)
Han, Doo Won (Jeonbuk Institute for Bioindustry)
Song, Yoon Seok (Jeonbuk Institute for Bioindustry)
Song, Jinwoo (Jeonbuk Institute for Bioindustry)
Choi, Kyung-Chul (Department of Biomedical Sciences, University of Ulsan College of Medicine)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.8, 2015 , pp. 1105-1113 More about this Journal
Abstract
Bokbunja (Rubus coreanus) is a Korean fruit and wild black raspberry that has antioxidant, anticancer, and beauty effects due to its abundant polyphenols and anthocyanins. The purpose of this study was to investigate the blood flow improvement effect of Bokbunja seed oil (BSO) in a high-fat diet-fed mouse model. We examined improvement of blood flow and its related biomarkers in vivo. Mice were divided into four groups; Control, high fat diet control (negative control, HFD), salmon oil control (positive control, HFD+commercial n-3 fatty acid), and BSO experiment groups (HFD+2 g/2,000 kcal, HFD+4 g/2,000 kcal). After the mice were sacrificed, plasma triglyceride, cholesterol, and blood flow-related biomarkers (coagulation factor 7, 12, serotonin, TXB2, PT, and aPTT) were measured in mouse blood and organs. BSO reduced blood viscosity through improvement of blood lipids (cholesterol and plasma triglycerides) as well as levels of blood coagulation factors and blood platelet activity. BSO also delayed blood coagulation time. Thus, we confirmed that BSO inhibits excessive blood clotting of blood vessels and improves blood flow. Taken together, these results suggest that BSO decreases plasma triglycerides and cholesterol and improves blood flow by regulating biomarkers.
Keywords
Bokbunja seed oil (BSO); Rubus coreanus; blood lipid; blood flow improvement; biomarker;
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