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http://dx.doi.org/10.3746/jkfn.2015.44.7.1064

Development of Spherical Granule of Fermented Red Ginseng Extracts  

Shin, Myung-Gon (Department of Food Science & Biotechnology, Woosong University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.7, 2015 , pp. 1064-1071 More about this Journal
Abstract
Viscous fermented red ginseng extracts were dried and coated using a fluidized bed coater to increase convenience and consumer acceptance. The methods for making spherical granules of fermented red ginseng extracts with increasing convenience were established by using indigestible dextrin. Spherical granules of fermented red ginseng extracts with increasing convenience were made by mixing indigestible dextrin at 40% (40% IDD), 50% (50% IDD), and 60% (60% IDD) versus the soluble solid content of fermented red ginseng extracts. Spherical granules of fermented red ginseng extracts showed less angle of repose than powder of fermented red ginseng extracts. This means that spherical granules of fermented red ginseng extracts had good fluency with increased convenience. The more indigestible dextrin showed higher yields. Although 50% IDD showed less yield than 60% IDD, 50% IDD was the best mixing ratio for making spherical granules of fermented red ginseng extracts, as fermented red ginseng extracts is known as a healthy food. The optimized operation conditions of the fluidized bed coater for making 50% IDD were feeding rate 0.54 mL/min, atomization air pressure 2.15 bar, and product temperature $83.03^{\circ}C$.
Keywords
fermented; ginseng; spherical granule; fluidized bed coater; convenience;
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1 Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol Pharm Bull 18: 1197-1202.   DOI
2 Park SJ, Kim DH, Kim SS. 2006. Preparation and quality characteristics of the fermentation product of ginseng by lactic acid bacteria (FGL). J Ginseng Res 30: 88-94.   DOI
3 Hamashita T, Nakagawa Y, Aketo T, Watano S. 2007. Granulation of core particles suitable for film coating by agitation fluidized bed I. Optimum formulation for core particles and development of a novel friability test method. Chem Pharm Bull (Tokyo) 55: 1169-1174.   DOI
4 Maulny APE, Beckett ST, Mackenzie G. 2005. Physical properties of co-crystalline sugar and honey. J Food Sci 70: E567-E572.
5 Wright BJ, Zevchak SE, Wright JM, Drake MA. 2009. The impact of agglomeration and storage on flavor and flavor stability of whey protein concentrate 80% and whey protein isolate. J Food Sci 74: S17-S29.   DOI
6 Cho HJ, Jung EY, Oh SH, Yoon B, Suh HJ, Lee HS. 2010. Microbial conversion of ginsenoside from the extract of Korean red ginseng (Panax ginseng) by Lactobacillus sp. J Food Sci Nutr 15: 105-112.   DOI   ScienceOn
7 Stone H, Sidel JL. 1993. Sensory evaluation. 2nd ed. Academic Press Inc., San Diego, CA, USA. p 251.
8 Patel YL, Sher P, Pawar AP. 2006. The effect of drug concentration and curing time on processing and properties of calcium alginate beads containing metronidazole by response surface methodology. AAPS PharmSciTech 7: E1-E7.
9 Ehlers H, Liu A, Raikkonen H, Hatara J, Antikainen O, Airaksinen S, Heinamaki J, Lou H, Yliruusi J. 2009. Granule size control and targeting in pulsed spray fluid bed granulation. Int J Pharm 377: 9-15.   DOI
10 Fries L, Antonyuk S, Heinrich S, Dopfer D, Palzer S. 2013. Collision dynamics in fluidised bed granulators: A DEMCFD study. Chem Eng Sci 86: 108-123.   DOI
11 Tan HS, Salman AD, Hounslow MJ. 2006 Kinetics of fluidised bed melt granulation I: The effect of process variables. Chem Eng Sci 61: 1585-1601.   DOI
12 Lee GH, Shin MG. 2009. Production of spherical granule from viscous red ginseng extracts for improving product fluency and preservation and its physicochemical properties. J Food Sci 74: E519-E525.   DOI
13 Bouwman AM, Visser MR, Meesters GM, Frijlink HW. 2006. The use of Stokes deformation number as a predictive tool for material exchange behaviour of granules in the 'equilibrium phase' in high shear granulation. Int J Pharm 318: 78-85.   DOI
14 Noh KH, Son JW, Kim HJ, Oh DK. 2009. Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus. Biosci Biotechnol Biochem 73: 316-321.   DOI
15 Wu JY, Gardner BH, Murphy CI, Seals JR, Kensil CR, Recchia J, Beltz GA, Newman GW, Newman MJ. 1992. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J Immunol 148: 1519-1525.
16 Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, Azuma I. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull 17: 635-639.   DOI
17 Liu ZQ, Luo XY, Liu GZ, Chen YP, Wang ZC, Sun YX. 2003. In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. J Agric Food Chem 51: 2555-2558.   DOI
18 Popovich DG, Kitts DD. 2002. Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 406: 1-8.   DOI
19 Hsu S. 2005. Green tea and the skin. J Am Acad Dermatol 52: 1049-1059.   DOI
20 Jukes TH, Cantor C. 1969. Evolution of protein molecules. In Mammalian Protein Metabolism. Munro HN, ed. Academic Press Inc., New York, NY, USA. p 21-132.
21 Park HJ, Jung DH, Joo H, Kang NS, Jang SA, Lee JG, Sohn EH. 2010. The comparative study of anti-allergic and anti- inflammatory effects by fermented red ginseng and red ginseng. Korean J Plant Res 23: 415-422.
22 Kim SJ, Murthy HN, Hahna EJ, Lee HL, Paek KY. 2007. Parameters affecting the extraction of ginsenosides from the adventitious roots of ginseng (Panax ginseng C.A. Meyer). Sep Purif Technol 56: 401-406.   DOI
23 Amidon GL, Lennernäs H, Shah VP, Crison JR. 1995. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12: 413-420.   DOI
24 Kim BG, Choi SY, Kim MR, Suh HJ, Park HJ. 2010. Changes of ginsenosides in Korean red ginseng (Panax ginseng) fermented by Lactobacillus plantarum M1 Process Biochem 45: 1319-1324.   DOI
25 Kim DH. 2009. Metabolism of ginsenosides to bioactive compounds by intestinal microflora and its industrial application. J Ginseng Res 33: 165-176.   DOI
26 Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T. 1963. Studies on the constituents of japanese and chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull (Tokyo) 11: 759-761.   DOI
27 Han BH, Park MH, Han YN, Woo LK, Sankawa U, Yahara S, Tanaka O. 1982. Degradation of ginseng saponins under mild acidic conditions. Planta Med 44: 146-149.   DOI   ScienceOn
28 Ko SR, Suzuki Y, Choi KJ, Kim YH. 2000. Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1. Biosci Biotechnol Biochem 64: 2739-2743.   DOI