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http://dx.doi.org/10.3746/jkfn.2015.44.4.491

Beneficial Effects of Daebong Persimmon against Oxidative Stress, Inflammation, and Immunity in vivo  

Lee, Hee Jae (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
Lim, So Young (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
Kang, Min-Gyung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
Park, Jeongjin (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
Chung, Hyun-Jung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University)
Yang, Soo Jin (Department of Food and Nutrition, Seoul Women's University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.4, 2015 , pp. 491-496 More about this Journal
Abstract
The purpose of this study was to assess the antioxidant, anti-inflammatory, and immuno-enhancing effects of Daebong persimmon (DP) and Bansi (BS) in vivo. Two types of astringent persimmons (DP and BS) were used for this experiment. C57BL/6J mice were assigned to the following groups: 1) lean control, 2) high-fat diet control (HF), 3) A region DP (3% wt/wt) with HF diet (A-DP), 4) B region DP with HF diet (B-DP), 5) C region DP with HF diet (C-DP), 6) D region BS with HF diet (D-BS), and 7) E region BS with HF diet (E-BS). All mice were sacrificed after 4 weeks of treatment, after which blood and tissues were collected. Antioxidant enzyme activities, inflammatory markers, and immune factors were evaluated. DP and BS treatments did not alter food intake or body weight, compared with HF. Administration of B-DP increased catalase activities in serum. Hepatic levels of malondialdehyde, a product of lipid peroxidation, were significantly lower in A-DP mice than in the HF group. A-DP had down-regulatory effects against inflammation induced by high-fat diet feeding, as shown by significant reduction of interleukin (IL)-$1{\beta}$, IL-6, and tumor necrosis factor-${\alpha}$. Additionally, A-DP treatment exerted an immuno-stimulatory effect, as shown by increasing levels of immunoglobulin G. DP treatment improved the level of insulin-like growth factor-1. These results indicate that DP has beneficial health effects on oxidative stress, inflammation, and immunity in vivo.
Keywords
anti-oxidative effect; anti-inflammatory effect; Daebong persimmon; immuno-enhancing activities;
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