Browse > Article
http://dx.doi.org/10.3746/jkfn.2015.44.4.475

Effect of Oligonol, a Low Molecular Weight Polyphenol Derived from Lychee on Oxidative Stress-Related Hepatic Damage in Streptozotocin-Induced Diabetic Rats  

Noh, Jeong Sook (Department of Food Science & Nutrition, Tongmyong University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.4, 2015 , pp. 475-482 More about this Journal
Abstract
This study was conducted to examine whether or not oligonol, a low molecular weight polyphenol derived from lychee fruit, has an ameliorative effect on diabetes-induced oxidative stress-related hepatic damage in streptozotocin (STZ)-induced diabetic rats. Oligonol (10 or 20 mg/kg body weight; O10 or O20, respectively) was orally administered every day for 10 days to STZ-induced diabetic rats, and its effects were compared to vehicle-treated diabetic (Veh) and non-diabetic rats. Administration of 20 mg/kg of oligonol significantly decreased liver weight compared with the Veh group (P<0.05). Elevated levels of hepatic glucose, reactive oxygen species, peroxynitrite, and lipid peroxidation were detected in diabetic vehicle rats, whereas oligonol treatment significantly attenuated these levels (P<0.05). In diabetic vehicle rats, hepatic antioxidant enzyme protein levels decreased, whereas oligonol treatment showed significant elevated results. For inflammation-related protein expression, oligonol-treated groups showed insignificant reduction. Oligonol improved expression of proapoptotic protein caspase-3 in the liver of diabetic rats (P<0.05). In conclusion, these results provide important evidence that oligonol exhibits an inhibitory effect on oxidative stress and apoptosis-related protein expression as well as a hepato-protective effect against the development of diabetic complications in STZ-induced type 1 diabetic rats.
Keywords
oligonol; diabetic rat; hepatic damage; oxidative stress; caspase-3;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ministry for Health, Welfare and Family Affairs. The Forth Korea National Health and Nutrition Examination Survey (KNHANES IV). http://www.mw.go.kr/front_new/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&CONT_SEQ=305115&page=1 (accessed Oct 2014).
2 Ahn KJ. 2010. Westernization of Korean diabetes. Korean Clin Diabetes J 11: 91-94.
3 Sakurai T, Tsuchiya S. 2006. Superoxide production from nonenzymatically glycated protein. FEBS Lett 236: 406-410.
4 Lyons TJ. 1991. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabet Med 8: 411-419.   DOI
5 Tai ES, Lim SC, Tan BY, Chew SK, Heng D, Tan CE. 2000. Screening for diabetes mellitus: a two-step approach in individuals with impaired fasting glucose improves detection of those at risk of complications. Diabet Med 17: 771-775.   DOI
6 Schattenberg JM, Schuchmann M. 2009. Diabetes and apoptosis: liver. Apoptosis 14: 1459-1471.   DOI
7 Nakagami H, Morishita R, Yamamoto K, Yoshimura SI, Taniyama Y, Aoki M, Matsubara H, Kim S, Kaneda Y, Ogihara T. 2001. Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. Diabetes 50: 1472-1481.   DOI
8 Winslow LC, Kroll DJ. 1998. Herbs as medicines. Arch Intern Med 158: 2192-2199.   DOI
9 Jones PJ, Varady KA. 2008. Are functional foods redefining nutritional requirements? Appl Physiol Nutr Metab 33: 118-123.   DOI
10 Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T. 1993. Inhibition of the infectivity of influenza virus by tea polyphenols. Antiviral Res 21: 289-299.   DOI
11 Hsieh TC, Wu JM. 1999. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp Cell Res 249: 109-115.   DOI
12 Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T, Sa G. 2001. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun 288: 658-665.   DOI
13 Brat P, George S, Bellamy A, Du Chaffaut L, Scalbert A, Mennen L, Arnault N, Amiot MJ. 2006. Daily polyphenol intake in France from fruit and vegetables. J Nutr 136: 2368-2373.
14 Haslam E. 1998. Practical polyphenolics, from structure to molecular recognition and physiological action. 16th ed. Cambridge University Press, Cambridge, UK. p 192-194.
15 Tanaka T, Yoshitake N, Zhao P, Matsuo Y, Kouno I, Nonaka G. 2007. Production of oligomeric proanthocyanidins by fragmentation of polymers. Jpn J Food Chem 14: 134-139.
16 Jo EH, Lee SJ, Ahn NS, Park JS, Hwang JW, Kim SH, Aruoma OI, Lee YS, Kang KS. 2007. Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling. Eur J Cancer Prev 16: 342-347.   DOI
17 Kundu JK, Chang EJ, Fujii H, Sun B, Surh YJ. 2008. Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin-AP-1 and C/EBP as potential upstream targets. Photochem Photobiol 84: 399-406.   DOI
18 Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y. 2010. Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol 159: 928-938.   DOI
19 Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, Kizaki T, Izawa T, Ishida H, Ohno H. 2009. Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway. Phytother Res 23: 1626-1633.   DOI
20 Mittal A, Elmets CA, Katiyar SK. 2003. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24: 1379-1388.   DOI
21 Noh JS, Kim HY, Park CH, Fujii H, Yokozawa T. 2010. Hypolipidaemic and antioxidative effects of oligonol, a lowmolecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice. Br J Nutr 104: 1120-1128.   DOI
22 Noh JS, Park CH, Yokozawa T. 2011. Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism. Br J Nutr 106: 1013-1022.   DOI   ScienceOn
23 Park CH, Yokozawa T, Noh JS. 2014. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice. J Nutr 144: 1150-1157.   DOI
24 Momose T, Yano Y, Ohashi K. 1963. Organic analysis. XL IV. A new deproteinizing agent for determination of blood sugar. Chem Pharm Bull (Tokyo) 11: 968-972.   DOI
25 Ali SF, LeBel CP, Bondy SC. 1992. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 12: 637-648.
26 Kooy NW, Royall JA, Ischiropoulos H, Beckman JS. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic Biol Med 16: 149-156.   DOI
27 Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95: 351-358.   DOI
28 Lowry OH, Rosebrough NH, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
29 Goldberg RB. 1981. Lipid disorders in diabetes. Diabetes Care 4: 561-572.   DOI
30 Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB. 2004. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest 114: 1666-1675.   DOI
31 Ceriello A. 2000. Oxidative stress and glycemic regulation. Metabolism 49: 27-29.   DOI
32 Sharpe PC, Liu WH, Yue KK, McMaster D, Catherwood MA, McGinty AM, Trimble ER. 1998. Glucose-induced oxidative stress in vascular contractile cells: comparison of aortic smooth muscle cells and retinal pericytes. Diabetes 147: 801-809.
33 Ebadi M, Sharma SK. 2003. Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Antioxid Redox Signal 5: 319-335.   DOI
34 Epe B, Ballmaier D, Roussyn I, Briviba K, Sies H. 1996. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res 24: 4105-4110.   DOI
35 Bordan C. 2001. Nitric oxide and the immune response. Nat Immunol 2: 907-916.   DOI
36 Ruiz C, Alegría A, Barberá R, Farré R, Lagarda MJ. 1999. Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus. Scand J Clin Lab Invest 59: 99-105.   DOI
37 Kesavulu MM, Giri R, Kameswara Rao B, Apparao C. 2000. Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes Metab 26: 387-392.
38 Hayes JD, Ellis EM, Neal GE, Harrison DJ, Manson MM. 1999. Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. Biochem Soc Symp 64: 141-168.
39 Nohl H, Jordan W. 1980. The metabolic fate of mitochondrial hydrogen peroxide. Eur J Biochem 111: 203-210.
40 Aliciguzel Y, Ozen I, Aslan M, Karayalcin U. 2003. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med 142: 172-177.   DOI
41 Henning SM, Fajardo-Lira C, Lee HW, Youssefian AA, Go VL, Heber D. 2003. Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity. Nutr Cancer 45: 226-235.   DOI
42 Boden G. 2011. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18: 139-143.   DOI
43 Kumar MV, Shimokawa T, Nagy TR, Lane MD. 2002. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci USA 99: 1921-1925.
44 Boghdady NA. 2013. Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochem Funct 31: 344-351.   DOI
45 Montane J, Cadavez L, Novials A. 2014. Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. Diabetes Metab Syndr Obes 7: 25-34.
46 Akash MS, Rehman K, Chen S. 2013. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. J Cell Biochem 114: 525-531.   DOI
47 Robertson JD, Orrenius S. 2000. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol 30: 609-627.   DOI
48 Babu PV, Liu D, Gilbert ER. 2013. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem 24: 1777-1789.   DOI   ScienceOn