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http://dx.doi.org/10.3746/jkfn.2015.44.3.307

Effects of Curcuma longa L. Extracts on Natural Killer Cells and T Cells  

Ha, Yejin (Department of Medical Nutrition, Kyung Hee University)
Kim, Ok-Kyung (Department of Medical Nutrition, Kyung Hee University)
Nam, Da-Eun (Department of Medical Nutrition, Kyung Hee University)
Kim, Yongjae (Korea INSPharm Research Institute)
Kim, Eun (Korea INSPharm Research Institute)
Jun, Woojin (Department of Food and Nutrition, Chonnam National University)
Lee, Jeongmin (Department of Medical Nutrition, Kyung Hee University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.3, 2015 , pp. 307-313 More about this Journal
Abstract
The present study investigated the immunomodulatory effects of Curcuma longa L. ethanol extracts on natural killer (NK) cells and T cells. We treated Curcuma longa L. ethanol extracts at concentrations of 20, 50, 100, and $150{\mu}g/mL$ to murine NK cells co-incubated with YAC-1 cells. Curcuma longa L. ethanol extracts resulted in increased NK cell activity compared to the control group at all concentrations. In the groups treated with Curcuma longa L. ethanol extracts, CD69 and IFN-${\gamma}$ expression levels significantly increased compared to the control group at 100 and $150{\mu}g/mL$. In addition, Curcuma longa L. ethanol extracts induced significant elevation of CD8+ T cell numbers in a dose-dependent manner. However, Curcuma longa L. ethanol extracts also led to reduction of CD4+ T cell and MHCII numbers. The findings of this study suggest that Curcuma longa L. ethanol extracts could enhance the immune response through activation of NK and cytotoxic T cells due to a proliferative shift of antigen presentation from MHCII to MHCI, presumably.
Keywords
Curcuma longa L.; NK cell; T cell; immunomodulating activity;
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