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http://dx.doi.org/10.3746/jkfn.2015.44.1.024

Single Dose Oral Toxicity of Bacillus subtilis JNS in ICR Mice  

Kim, Kyoung-Hoon (JNS Tech Co.)
Jeong, Chang Hwa (JNS Tech Co.)
Joo, Seong-Je (Department of Life Science and Biotechnology, Dongeui University)
Park, Jong-Hoon (Department of Life Science and Biotechnology, Dongeui University)
Moon, Ji-Young (Department of Life Science and Biotechnology, Dongeui University)
Cho, Eun-Ji (Department of Life Science and Biotechnology, Dongeui University)
Lee, Hyun-Tai (Department of Life Science and Biotechnology, Dongeui University)
Kwon, Hyun-Ju (Department of Life Science and Biotechnology, Dongeui University)
Kim, Byung-Woo (Department of Life Science and Biotechnology, Dongeui University)
Eom, Sung-Hwan (Food Resource Research Center, Korea Food Research Institute)
Lee, Eun-Woo (Department of Life Science and Biotechnology, Dongeui University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.1, 2015 , pp. 24-28 More about this Journal
Abstract
The present study was carried out to investigate the in vivo single-dose acute toxicity of Bacillus subtilis JNS isolated from Cheonggukjang, which is a probiotic candidate showing strong and broad antibacterial activity. The test sample was orally administrated to male and female ICR mice at a highest dose of 2,000 mg/kg for 14 days. No significant change in general conditions, mortalities, body weight changes, clinical signs, autopsy findings, or presence of gross lesions was observed in either sex of mice. The results indicate that up to 2,000 mg/kg of B. subtilis JNS had no adverse effect on ICR mice.
Keywords
single dose oral toxicity; Bacillus subtilis; ICR mice; Cheonggukjang;
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Times Cited By KSCI : 4  (Citation Analysis)
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