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http://dx.doi.org/10.3746/jkfn.2015.44.1.001

Anti-Atopic Activity of Tuna Heart Ethanol Extract  

Kang, Bo-Kyeong (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences, Pukyoung National University)
Kim, Min-Ji (Institute of Fisheries Sciences, Pukyoung National University)
Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Pak, Won-Min (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Kim, Bo-Ram (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Ahn, Na-Kyung (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Choi, Yeon-Uk (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Bae, Nan-Young (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Park, Ji-Hye (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyoung National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.1, 2015 , pp. 1-6 More about this Journal
Abstract
Atopic dermatitis (AD) is a form of allergic skin inflammatory characterized by late eczematous skin lesions. The incidence of AD is increasing, and it causes problems with administrative costs. Therefore, development of an AD treatment with no side effects is needed. The purpose of this study was to evaluate tuna heart ethanol extract (THEE), a functional extract from by-product of tuna. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the backside of BALB/c mice. The effect of THEE was tested by measuring skin clinical severity score, secretion of cytokines and IgE, and proliferation. Secretion of $TNF-{\alpha}$, IL-4, IL-5, IL-13, and IgE significantly decreased in a THEE-independent manner. In contrast, levels of IL-10 and $IFN-{\gamma}$ significantly increased in mice sera and splenocytes. In addition, THEE alleviated AD symptoms compared to the DNCB only group. In conclusion, these results demonstrate that THEE has an inhibitory effect on AD and may be a useful substance for the development of cosmeceuticals.
Keywords
tuna heart ethanol extract; atopic dermatitis; IgE; skin severity score;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. 2004. New insights into atopic dermatitis. J Clin Invest 113: 651-657.   DOI   ScienceOn
2 Ahn KM. 2004. Role of mast cells in allergic inflammation and innate immunity. Korean J Pediatr 47: 1137-1141.   과학기술학회마을
3 Epstein PR. 2005. Climate change and human health. N Engl J Med 353: 1433-1436.   DOI
4 Leung DYM. 1999. Pathogenesis of atopic dermatitis. J Allergy Clin Immunol 104: S99-108.   DOI
5 Kevin DC. 1994. Atopic dermatitis: recent trends in pathogenesis and therapy. J Invest Dermatol 102: 128-137.   DOI
6 Novak N, Simon D. 2011. Atopic dermatitis-from new pathophysiologic insights to individualized therapy. Allergy 66: 830-839.   DOI
7 Sidbury R, Hanifin JM. 2000. Old, new, and emerging therapies for atopic dermatitis. Dermatol Clin 18: 1-11.
8 Choi J, Kim JH, Lee JW. 2011. Physiological properties of tuna cooking drips hydrolysate prepared with gamma irradiation. Process Biochem 46: 1875-1878.   DOI
9 Je JY, Qian ZJ, Byun HG, Kim SK. 2007. Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzyme hydrolysis. Process Biochem 42: 840-846.   DOI
10 Hwang WI, Baik NG, Hwang YK, Lee SD. 1992. Antitumor and immunological effects of tuna extract. J Korean Soc Food Nutr 21: 353-366.
11 Jung HS. 2007. Antioxidant effect of histidine containing low molecular weight peptide isolated from skipjack boiled extract. Korean J Food Cookery Sci 23: 221-226.   과학기술학회마을
12 Shin MO, Ku MJ, Bae SJ. 2007. Cytotoxicity and quinone reductase activity stimulating effects of fin of Thunnus thynnus extracts in various cancer cells. Korean J Nutr 40: 147-153.   과학기술학회마을
13 Park SE, Kim HW, Lee SR, Kim BK. 2000. Effects of nucleic acids complex of tuna testis on immunological activities. J Korean Assoc Cancer Prev 5: 15-23.
14 Munoz C, Carlet J, Fitting C, Misset B, Blériot JP, Cavaillon JM. 1991. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 88: 1747-1754.   DOI
15 Ahn JY, Im LR, Park JH, Kim DH, Lee MY. 2009. Effects of Rumecis Radix water extract on development of atopic dermatitis in BALB/c mice. Kor J Pharmacogn 40: 218-223.   과학기술학회마을
16 Renz H, von Mutius E, Illi S, Wolkers F, Hirsch T, Weiland SK. 2002. T(H)1/T(H)2 immune response profiles differ between atopic children in eastern and western Germany. J Allergy Clin Immunol 109: 338-342.   DOI
17 Suzuki R, Shimizu T, Kudo T, Ohtsuka Y, Yamashiro Y, Oshida K. 2002. Effects of n-3 polyunsaturated fatty acids of dermatitis in NC/Nga mice. Prostaglandins Leukot Essent Fatty Acids 66: 435-440.   DOI
18 Lee YH. 2007. Effect of Phellinus linteus grown in germinated brown rice on atopic dermatitis. J Kor Soc Cosm 13: 514-519.
19 Powrie F, Coffman RL. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Trends Pharm Sci 14: 164-168.   DOI
20 Novak N, Bieber T. 2003. Allergic and nonallergic forms of atopic diseases. J Allergy Clin Immunol 112: 252-262.   DOI
21 Beltrani VS. 1999. The clinical spectrum of atopic dermatitis. J Allergy Clin Immunol 104: S87-98.   DOI
22 Smith JR, Hart PH, Williams KA. 1998. Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis. Immunol Cell Biol 76: 497-512.   DOI
23 Gonzalez-Rey E, Chorny A, Delgado M. 2007. Regulation of immune tolerance by anti-inflammatory neuropeptides. Nat Rev Immunol 7: 52-63.   DOI
24 Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. 1993. Interleukin-10. Annu Rev Immunol 11: 165-190.   DOI