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http://dx.doi.org/10.3746/jkfn.2014.43.6.807

Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats  

Cho, Byoung Ok (Advanced Radiation Technology Institute, Korea Atomic & Energy Research Institute)
Lee, Chang-Wook (Advanced Radiation Technology Institute, Korea Atomic & Energy Research Institute)
So, Yangkang (Advanced Radiation Technology Institute, Korea Atomic & Energy Research Institute)
Jin, Chang-Hyun (Advanced Radiation Technology Institute, Korea Atomic & Energy Research Institute)
Yook, Hong-Sun (Dept. of Food and Nutrition, Chungnam National University)
Byun, Myung-Woo (Dept. of Culinary Nutrition, Woosong University)
Jeong, Yong-Wook (Dept. of Microbiology, College of Medicine, Seonam University)
Park, Jong Chun (Dept. of Microbiology, College of Medicine, Seonam University)
Jeong, Il-Yun (Advanced Radiation Technology Institute, Korea Atomic & Energy Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.6, 2014 , pp. 807-813 More about this Journal
Abstract
The objective of the present study was to investigate the protective effects of anthocyanin-enriched extract from radiation-induced blackberry (Rubus fruticosus L.) mutant (${\gamma}$-B201) against carbon tetrachloride ($CCl_4$)-induced liver injury in Spargue-Dawley (SD) rats. The in vivo results show that ${\gamma}$-B201 attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in $CCl_4$-treated SD rats. Histopathological examination of rat livers showed that ${\gamma}$-B201 reduced the incidence of liver lesions induced by $CCl_4$. Moreover, ${\gamma}$-B201 prevented DNA damage in $CCl_4$-treated SD rats. Furthermore, administration of ${\gamma}$-B201 significantly increased the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), in $CCl_4$-treated rat livers. In conclusion, the present study suggests that ${\gamma}$-B201 blackberry extract protects the liver from $CCl_4$-induced hepatic damage through an antioxidant mechanism. Therefore, ${\gamma}$-B201 blackberry may be functional food material for human health.
Keywords
blackberry; carbon tetrachloride; lipid peroxidation; DNA damage; antioxidant enzyme;
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Times Cited By KSCI : 5  (Citation Analysis)
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