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http://dx.doi.org/10.3746/jkfn.2014.43.3.341

Anti-obesity and Anti-hyperlipidemic Activities of Fermented Coffee with Monascus ruber Mycelium by Solid-State Culture of Green Coffee Beans  

Sung, Jeehey (Dept. of Food Science and Biotechnology, Chungbuk National University)
Shin, Ji-Young (R&D Center, CosisBio Co., Ltd.)
Kim, Hoon (R&D Center, CosisBio Co., Ltd.)
Baek, Gil-Hun (Dept. of Food Science and Biotechnology, Chungbuk National University)
Yu, Kwang-Won (Dept. of Food and Nutrition, Korea National University of Transportation)
Yeon, Jeyeong (Dept. of Food Science and Biotechnology, Chungbuk National University)
Lee, Junsoo (Dept. of Food Science and Biotechnology, Chungbuk National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.3, 2014 , pp. 341-348 More about this Journal
Abstract
We investigated the anti-obesity and anti-hyperlipidemic effects of extracts of two roasted coffee beans (Vietnam robusta and Ethiopia mocha sidamo G2) and fermented coffee beans with Monascus rubber mycelium (MR) by solid-state culture. C57B/L6 mice were divided into seven groups: normal diet (ND) group, high fat diet (HFD) group, and HFD groups with hot water extracts from Vietnam robusta coffee beans (HFD-VR), MR-fermented Vietnam robusta coffee beans (HFD-VR-MR), MR-fermented Vietnam robusta coffee beans with 10% brown rice (HFD-VR-MR-BR10), Ethiopia mocha sidamo G2 coffee beans (HFD-ES), and MR-fermented Ethiopia mocha sidamo G2 coffee beans (HFD-ES-MR). After 6 weeks, body weight gain and food efficiency ratio were higher in the HFD group, but significantly reduced in the coffee extracts-fed groups. The HFD-ES-MR group showed greater body weight reduction than the HFD-ES group. The serum triglyceride, total cholesterol, and LDL-cholesterol levels as well as the atherogenic index and cardiac risk factor all tended to decrease in groups fed Vietnam robusta coffee extracts compared to the HFD group. These results suggest that Vietnam robusta and Ethiopia mocha sidamo G2 may be used to make functional coffee beverages with anti-obesity and anti-hyperlipidemic activities.
Keywords
Monascus rubber; fermentation; coffee; anti-obesity; anti-hyperlipidemia;
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Times Cited By KSCI : 12  (Citation Analysis)
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1 Park SJ, Jeon YJ, Kim HJ, Han JS. 2013. Anti-obesity effects of Ishige okamurae extarct in C57BL/6J mice fed high-fat diet. Korea J Food Sci Technol 45: 199-205.   DOI   ScienceOn
2 Kim AR, Lee JJ, Lee YM, Jung HO, Lee MY. 2010. Cholesterol-lowering and anti-obesity effects of Polymnia sonchifolia Poepp. & Endl. powder in rats fed a high fat-high cholesterol diet. J Korean Soc Food Sci Nutr 39: 210-218.   과학기술학회마을   DOI
3 Rosenfeld L. 1989. Lipoprotein analysis: Early methods in the diagnosis of atherosclerosis. Arch Pathol Lab Med 113: 1101-1110.
4 Hecimovic I, Belscak-Cvitanovic A, Horzic D, Komes D. 2011. Comparative study of polyphenols and caffeine in different coffee varieties affected by the degree of roasting. Food Chem 129: 991-1000.   DOI   ScienceOn
5 Mackay DC, Rollins JW. 1989. Caffeine and caffeinism. J R Nav Med Serv 75: 65-67.
6 Shin JY, Kim H, Kim DG, Baek GH, Jeong HS, Yu KW. 2013. Pharmacological activities of coffee roasted from fermented green coffee beans with fungal mycelia in solid-state culture. J Korean Soc Food Sci Nutr 42: 487-496.   과학기술학회마을   DOI   ScienceOn
7 Natella F, Nardini M, Belelli F, Scaccini C. 2007. Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am J Clin Nutr 86: 604-609.
8 Olthof MR, Hollman PC, Buijsman MN, van Amelsvoort JM, Katan MB. 2003. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr 133: 1806-1814.
9 Endo A. 1980. Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Antibiot (Tokyo) 33: 334-336.   DOI
10 Endo A, Hasumi K, Negishi S. 1985. Monacolin J and L, new inhibitors of cholesterol biosynthesis produced by Monascus rubber. J Antibiot (Tokyo) 38: 420-422.   DOI
11 Pyo YH. 2008. Effect of Monascus-fermentation on the content of GABA and free amino acids in soybean. J Korean Soc Food Sci Nutr 37: 1208-1213.   과학기술학회마을   DOI   ScienceOn
12 Cha JY, Park JC, Ahn HY, Eom KE, Park BK, Jun BS, Lee CH, Cho YS. 2009. Effect of Monascus purpureus-fermented Korean red ginseng powder on the serum lipid levels and antioxidative activity in rats. Korean J Soc Food Sci Nutr 38: 1153-1160.   과학기술학회마을   DOI
13 Lee SK, Chun GT, Jeong YS. 2008. Production medium optimization for Monascus biomass containing high content of monacolin-K by using soybean flour substrates. Korean J Biotechnol Bioeng 23: 463-469.   과학기술학회마을
14 Kim EY, Rhyu MR. 2000. The chemical properties of doenjang prepared by Monascus koji. Korean J Food Sci Technol 32: 1114-1121.   과학기술학회마을
15 Kim MJ, Park JE, Lee JH, Choi NR, Hong MH, Pyo YH. 2013. Antioxidant capacity and bioactive composition of a single serving size of regular coffee varieties commercially available in Korea. Korean J Food Sci Technol 45: 299-304.   과학기술학회마을   DOI   ScienceOn
16 Song YO, Lee SJ, Park HJ, Jang SH, Chung BY, Song YM, Kim GS, Cho JH. 2013. Hepatoprotective effect of Schisandra chinensis on high-fat diet-induced fatty liver in rats. Korean J Vet Serv 36: 45-52.   과학기술학회마을   DOI   ScienceOn
17 Kim ST, Hwang CH, Kim YK. 2012. The effect of natural mate tea extract on the body weight and biochemical biomarker in high fat diet-obese (ob/ob) mice. Yakhak Hoeji 56: 1-8.   과학기술학회마을
18 Kang ES, Hang JS, Lee CK, Seo HG. 2013. Effects of Garcinia cambogia extract on the adipogenic differentiation and lipotoxicity. Korean J Food Sci Ani 33: 411-416.   과학기술학회마을   DOI   ScienceOn
19 Vignoli JA, Bassoli DG, Benassi MT. 2011. Antioxidant activity, polyphenols, caffeine and melanoidins in soluble coffee: the influence of processing conditions and raw material. Food Chem 124: 863-868.   DOI   ScienceOn
20 Goya L, Delgado-Andrade C, Rufian-Henares JA, Bravo L, Morales FJ. 2007. Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide. Mol Nutr Food Res 51: 536-545.   DOI   ScienceOn
21 Miller NE, Thelle DS, Forde OH, Mjos OD. 1977. The Tromso heart-study: High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet 8019: 965-968.
22 An JH, Mahat B, Lee BY, Park WK, Kwon KI. 2012. Evaluation of the caffeine contents in tea and coffee by HPLC and effect of caffeine on behavior in rats. Kor J Clin Pharm 22: 167-175.   과학기술학회마을
23 Wan CW, Wong CN, Pin WK, Wong MH, Kwok CY, Chan RY, Yu PH, Chan SW. 2013. Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-${\alpha}$ in hyper-cholesterolemic rats induced with a high-cholesterol diet. Phytother Res 27: 545-551.   DOI   ScienceOn
24 Higdon JV, Frei B. 2006. Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 46: 101-123.   DOI   ScienceOn
25 Moreira DP, Monterio MC, Ribeiro-Alves M, Donangelo CM, Trugo LC. 2005. Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agric Food Chem 53: 1399-1402.   DOI   ScienceOn
26 Park IB, Park BS, Jung ST. 2003. Brewing and functional characteristics of hongkuk ju prepared with various hongkuks. Korean J Food Sci Technol 35: 943-950.   과학기술학회마을