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http://dx.doi.org/10.3746/jkfn.2014.43.2.194

Anti-Obesity Effects of Lentinus edodes on Obese Mice Induced by High Fat Diet  

Lee, Mi Ra (Dept. of Food Science and Technology, Chungnam National University)
Oh, Deuk Sil (Jeollanam-do Forest Resource Research Institute)
Wee, An Jin (Jeollanam-do Forest Resource Research Institute)
Yun, Byung Sun (Jeollanam-do Forest Resource Research Institute)
Jang, Soon Ae (Hanbat University Industry Collaboration Foundation)
Sung, Chang Keun (Dept. of Food Science and Technology, Chungnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.2, 2014 , pp. 194-199 More about this Journal
Abstract
The aim of this study was to investigate the anti-obesity effects of Lentinus edodes water extract powder (LEP) in mice fed a high fat diet (HF, 45% kcal fat). Mice were administrated a HF diet supplemented with 1%, 3%, or 5% LEP for 12 weeks. Consumption of HF diet caused increases in body weight, serum lipid profiles, and adipose tissue weights. Serum TC and TG levels in the LEP-supplemented groups were lower than those in the NC group. Supplementation with 5% LEP significantly suppressed body weight gain and reduced the weight of subcutaneous adipose tissue compared to the HF group. HF diet ingestion resulted in higher lipid content and increased lipid peroxidation in the liver. However, LEP supplementation inhibited accumulation of hepatic lipids induced by HF diet, considerably decreased MDA levels, and elevated total antioxidant activity in the livers of mice in the 5% LEP group. Histopathological analysis indicated that the livers of mice fed HF diet developed hepatic steatosis, whereas LEP-treated groups showed small fat droplets. These results suggest that long-term supplementation with LEP may also have an ameliorating effect on HF-induced obesity.
Keywords
Lentinus edodes; high fat diet; obesity; antioxidant;
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